2015
DOI: 10.1002/cam4.418
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ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer

Abstract: Angiopoietin-like 3 (ANGPTL3), which is involved in new blood vessel growth and stimulation of mitogen-activated protein kinase (MAPK), is expressed aberrantly in several types of human cancers. However, little is known about the relevance of ANGPTL3 in the behavior of oral squamous cell carcinoma (OSCC). In this study, we evaluated ANGPTL3 mRNA and protein in OSCC-derived cell lines (n = 8) and primary OSCCs (n = 109) and assessed the effect of ANGPTL3 on the biology and function of OSCCs in vitro and in vivo… Show more

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Cited by 60 publications
(48 citation statements)
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“…A large number of proteins serve as targets that act on the oncogenesis and growth of oral tumor cells. These targets include angiopoietin-like 3, annexin A10, SH3 domain containing kinase binding protein 1, quaking 5, epidermal growth factor receptor, fibroblast activation protein, parathyroid hormone-related protein and 70-kDa ribosomal S6 kinase (34)(35)(36)(37)(38)(39)(40)(41). Their functions and molecular mechanisms in the MAPK signaling pathway that concern oral cancer are summarized in Table I.…”
Section: Action Mechanisms Of the Mapk Signaling Pathway In Oral Cancermentioning
confidence: 99%
“…A large number of proteins serve as targets that act on the oncogenesis and growth of oral tumor cells. These targets include angiopoietin-like 3, annexin A10, SH3 domain containing kinase binding protein 1, quaking 5, epidermal growth factor receptor, fibroblast activation protein, parathyroid hormone-related protein and 70-kDa ribosomal S6 kinase (34)(35)(36)(37)(38)(39)(40)(41). Their functions and molecular mechanisms in the MAPK signaling pathway that concern oral cancer are summarized in Table I.…”
Section: Action Mechanisms Of the Mapk Signaling Pathway In Oral Cancermentioning
confidence: 99%
“…The ERK/MAPK signaling pathway is widely expressed in many tissues and cells, and can regulate cell proliferation, the cell cycle, apoptosis, migration and invasion, and many other biological processes (22,23). Excessive activation of the ERK/MAPK signaling pathway can cause abnormal proliferation, apoptosis and differentiation of cells, and thus is associated with tumor occurrence, progression and metastasis, including gallbladder carcinoma (22), esophageal cancer (24), and breast cancer (24)(25)(26)(27).…”
Section: Discussionmentioning
confidence: 99%
“…ANGPTL3 is significantly induced in oral squamous cell carcinoma (OSCC) [36], whereby it activates the ERK pathway and promotes cell proliferation. In HCC in vitro cells, ANGPTL3 antisense oligodeoxynucleotides inhibit cell proliferation and invasion [37].…”
Section: Angptl3mentioning
confidence: 99%