ANGPTL4 regulate glutamine metabolism and fatty acid oxidation in nonsmall cell lung cancer cells

Song, Xin; Nai‐dong, Wang; Jin‐Xiang, Yan; Tian, Lei; Lu, Xiurong; Guo, Hong; Yan, Jie-Cheng; Fei, Zhang

doi:10.1111/jcmm.16879

Cited by 27 publications

(14 citation statements)

References 33 publications

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“…ANGPTL4 inhibits low-density lipoprotein (LDL) activity and increases circulating triacylglycerol (TAG) levels [ 55 ]. It was also proven to increase glutamine consumption and fatty acid oxidation in non-small cell lung cancer (NSCLC) [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

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Comprehensive Analysis of Potential Prognostic Values of ANGPTLs in Colorectal Cancer

Zhang

Yang

Liu

et al. 2022

Genes

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: Colorectal cancer (CRC) is one of the most common malignant tumors in the world. CRC recurrence and metastasis cause poor prognosis. ANGPTLs (angiopoietin-like proteins) are a family of proteins that are widely involved in metabolic disease and tumorigenesis. The roles of ANGPTLs in CRC are still controversial and deserve further research. In this study, several databases were employed to explore the expression profiles, prognostic values, genetic alterations, potential biological function, and immune infiltration correlation of ANGPTLs in CRC. The expression of ANGPTL4 was significantly positively correlated with the stage of CRC. Therefore, cell and molecular experiments were further performed to explore the roles of ANGPTL4. Our results showed that the transcriptions of ANGPTLs in colon cancer and rectal cancer tissues were lower than those in normal tissues, but the protein expression varied among different ANGPTLs. In addition, the high expression of ANGPTLs led to a relatively poor oncological outcome. Specifically, the expression of ANGPTL4 is significantly positively correlated with the stage of CRC. Further investigation revealed that ANGPTLs are mainly involved in signal transduction and the regulation of transcription, while KEGG pathway analyses demonstrated pathways in cancer. Additionally, we also observed that ANGPTL4 could promote the proliferation and migration of CRC cells, and four specific small molecule compounds had potential ANGPTL4-binding capabilities, suggesting the clinical application of these small molecule compounds on CRC treatment. Our findings imply the prognostic values and potential therapeutic targets of ANGPTLs in CRC.

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Section: Discussionmentioning

confidence: 99%

“…They were proven to function and regulate angiogenesis in the vascular system [ 11 ]. Later, ANGPTLs were reported to be widely involved in metabolic disease and tumorigenesis [ 13 , 14 , 15 , 16 , 17 ]. Specifically, ANGPTLs participate in the regulation of cell adhesion, migration, and angiogenesis in CRC [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Potential Prognostic Values of ANGPTLs in Colorectal Cancer

Zhang

Yang

Liu

et al. 2022

Genes

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“…In addition, CYP7A1 overexpression in the luteoloside intervention group was consistent with a significant increase in its enzymatic activity in the liver tissue. Angiopoietin-like protein 4 (Angptl4) is a key gene in the regulation of lipid and glucose metabolism ( 38 ), and hyperlipidemia levels were significantly reduced in Angptl4 knockout mice ( 39 ). The results of this study showed that compared with the control group, the expression of Angptl4 in liver tissues was downregulated after luteoloside intervention, but the difference was not statistically significant, indicating that Angptl4 may not be a key gene in the mechanism of luteolin lowering blood lipid.…”

Section: Discussionmentioning

confidence: 99%

The hypolipidemic mechanism of chrysanthemum flavonoids and its main components, luteolin and luteoloside, based on the gene expression profile

et al. 2022

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In this study, the following four groups of mice with hyperlipidemia were involved: the model control group (MC), the Chrysanthemum flavonoids group (CF), the luteolin group, and the luteoloside group. The whole gene expression profile was detected in the liver tissues of each group. Differential genes significantly enriched in the biological process of gene ontology (GO) items and Kyoto Encyclopedia of Genes and Genomes (KEGG) were selected, and 4 differential genes related to lipid metabolism were selected for further real-time quantitative PCR verification. Compared with the MC, 41 differential genes such as Sqle, Gck, and Idi1 were screened in the CF intervention group; 68 differential genes such as Acsl3, Cyp7a1, and Lpin1 were screened in the luteolin intervention group (CF); and 51 differential genes such as Acaca, Cyp7a1, and Lpin1 were screened in the luteoloside group. The mechanism of CF to improve hyperlipidemia is very complex, mainly involving biological processes such as cholesterol and fatty acid metabolism and glycolysis, luteolin mainly involves the synthesis and transport of cholesterol, and luteoloside mainly involves fatty acid metabolism. The functional pathways of CF may not be completely the same as luteolin and luteoloside, and further study is needed on the mechanism of action of other components.

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“…DNA methylation-mediated silencing of ANGPTL4 induces the activation of cancer-associated fibroblasts (CAFs) and help CRC transfer through the ERK pathway, enhancing its invasive ability [81]. Moreover, ANGPTL4 can participate in tumor energy metabolism in different NSCLC cells and affect cell proliferation through this process [82]. High expression of ANGPTL4 predicts adverse clinical outcomes in tumors, such as renal clear cell carcinoma, cholangiocarcinoma, melanoma, bladder cancer, and oral cancer [83][84][85][86][87].…”

Section: Discussionmentioning

confidence: 99%

Guidelines on lung adenocarcinoma prognosis based on immuno-glycolysis-related genes

et al. 2022

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Objectives This study developed a new model for risk assessment of immuno-glycolysis-related genes for lung adenocarcinoma (LUAD) patients to predict prognosis and immunotherapy efficacy. Methods LUAD samples and data obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases are used as training and test columns, respectively. Twenty-two (22) immuno-glycolysis-related genes were screened, the patients diagnosed with LUAD were divided into two molecular subtypes by consensus clustering of these genes. The initial prognosis model was developed using the multiple regression analysis method and Receiver Operating characteristic (ROC) analysis was used to verify its predictive potential. Gene set enrichment analysis (GSEA) showed the immune activities and pathways in different risk populations, we calculated immune checkpoints, immune escape, immune phenomena (IPS), and tumor mutation burden (TMB) based on TCGA datasets. Finally, the relationship between the model and drug sensitivity was analyzed. Results Fifteen (15) key differentially expressed genes (DEGs) with prognostic value were screened and a new prognostic model was constructed. Four hundred and forty-three (443) samples were grouped into two different risk cohorts based on median model risk values. It was observed that survival rates in high-risk groups were significantly low. ROC curves were used to evaluate the model’s accuracy in determining the survival time and clinical outcome of LUAD patients. Cox analysis of various clinical factors proved that the risk score has great potential as an independent prognostic factor. The results of immunological analysis can reveal the immune infiltration and the activity of related functions in different pathways in the two risk groups, and immunotherapy was more effective in low-risk patients. Most chemotherapeutic agents are more sensitive to low-risk patients, making them more likely to benefit. Conclusion A novel prognostic model for LUAD patients was established based on IGRG, which could more accurately predict the prognosis and an effective immunotherapy approach for patients.

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ANGPTL4 regulate glutamine metabolism and fatty acid oxidation in nonsmall cell lung cancer cells

Cited by 27 publications

References 33 publications

Comprehensive Analysis of Potential Prognostic Values of ANGPTLs in Colorectal Cancer

Comprehensive Analysis of Potential Prognostic Values of ANGPTLs in Colorectal Cancer

The hypolipidemic mechanism of chrysanthemum flavonoids and its main components, luteolin and luteoloside, based on the gene expression profile

Guidelines on lung adenocarcinoma prognosis based on immuno-glycolysis-related genes

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