Ortho‐positronium (o ‐Ps), which self‐annihilates into 3γ with a lifetime of 142ns, may be quenched through various interactions with atoms and molecules. The quenching process of o ‐Ps in gases, (i) pick‐off quenching, (ii) attachment (chemical) quenching, (iii) spin conversion quenching through electron exchange, (iv) spin conversion quenching through spin‐orbit interaction with a heavy atom, are reviewed. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)