On the level of single atoms and photons, the coupling between atoms and the electromagnetic field is typically very weak. By using a cavity to confine the field, the strength of this interaction can be increased by many orders of magnitude, to a point where it dominates over any dissipative process. This strong-coupling regime of cavity quantum electrodynamics 1,2 has been reached for real atoms in optical cavities 3 , and for artificial atoms in circuit quantum electrodynamics 4 and quantum dot systems 5,6 . A signature of strong coupling is the splitting of the cavity transmission peak into a pair of resolvable peaks when a single resonant atom is placed inside the cavity, an effect known as vacuum Rabi splitting. The circuit quantum electrodynamics architecture is ideally suited for going beyond this linear-response effect. Here, we show that increasing the drive power results in two unique nonlinear features in the transmitted heterodyne signal: the supersplitting of each vacuum Rabi peak into a doublet and the appearance of extra peaks with the characteristic √ n spacing of the Jaynes-Cummings ladder. These findings constitute direct evidence for the coupling between the quantized microwave field and the anharmonic spectrum of a superconducting qubit acting as an artificial atom.Circuit quantum electrodynamics (QED) realizes the coupling between a superconducting qubit and the microwave field inside an on-chip transmission-line resonator 4,7 . The drastic reduction in mode volume for such a quasi-one-dimensional system 8,9 , the recent improvement in coherence times 10 and the absence of atomic motion render circuit QED an ideal system for studying the strong-coupling limit. In the customary linear-response measurement of the transmitted microwave radiation, the vacuum Rabi splitting manifests itself as an avoided crossing between the qubit and the resonator.It may be argued that the observation of the splitting is not yet a clear sign for quantum behaviour 11,12 , because avoided crossings are also ubiquitous in classical physics. However, quantum mechanics gives rise to a distinct anharmonicity of these splittings when initializing the resonator in a higher photon Fock state: when the resonator mode is occupied by n photons, the splitting is enhanced by a factor √ n + 1 as compared with the vacuum Rabi situation. This anharmonicity has been observed with single atoms in both microwave 13 and optical cavities 14,15 . In circuit QED, this characteristic trait has been observed in time-domain measurements 16 . In a system similar to ours, the position of the n = 2 peaks was recently demonstrated in a two-tone pump-probe measurement 17 .Here, we present a theoretical analysis and experimental investigation of the vacuum Rabi resonance in a circuit QED system, where we study the √ n anharmonicity up to n = 5 by exploring the power dependence of the heterodyne transmission (see the Methods section). This type of detection is particularly simple, because it is a continuous measurement involving only a single dr...