Anhedonia

Myerson, Abraham

doi:10.1176/ajp.79.1.87

Cited by 34 publications

(27 citation statements)

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“…One possibility is that the attenuated positive affect characteristic of depression stems from difficulties sustaining affective responses to positive stimuli, rather than an attenuation of the overall affective response (19). Broadly consistent with this possibility is evidence that patients with depression have an impaired ability to integrate reward reinforcement history over consecutive trials (20), fail to sustain normative response bias toward reward-predicting cues (21) and that mothers experiencing postpartum depression demonstrate a lack of within-trials sustained ventral striatal activity to financial rewards (22).…”

mentioning

confidence: 99%

Relationships Between Changes in Sustained Fronto-Striatal Connectivity and Positive Affect in Major Depression Resulting From Antidepressant Treatment

Heller

Johnstone²,

Light³

et al. 2013

AJP

146

104

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Objective Deficits in positive affect and their neural bases have been associated with major depression. However, whether reductions in positive affect result solely from an overall reduction in nucleus accumbens activity and fronto-striatal connectivity or the additional inability to sustain engagement over time of this network is unknown. Accordingly, we sought to determine whether treatment-induced changes in the ability to sustain nucleus accumbens activity and fronto-striatal connectivity during the regulation of positive affect are associated with gains in positive affect. Method Using fMRI, we assessed the ability to sustain activity in reward-related networks when attempting to increase positive emotion during performance of an emotion regulation paradigm in 21 depressed patients prior to, and after 2 months of antidepressant treatment. 14 healthy control subjects were scanned over the same interval. Results After 2 months of treatment, self-reported positive affect increased. Those patients demonstrating the largest increases in sustained nucleus accumbens activity over the 2 months were those demonstrating the largest increases in positive affect. In addition, those patients demonstrating the largest increases in sustained fronto-striatal connectivity were also those demonstrating the largest increases in positive affect when controlling for negative affect. Healthy controls showed none of these associations. Conclusions Treatment induced changes in the sustained engagement of fronto-striatal circuitry tracks the experience of positive emotion in daily life. Studies examining reduced positive affect in a variety of psychiatric disorders might benefit from examining the temporal dynamics of brain activity when attempting to understand changes in daily positive affect.

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confidence: 99%

Relationships Between Changes in Sustained Fronto-Striatal Connectivity and Positive Affect in Major Depression Resulting From Antidepressant Treatment

Heller

Johnstone²,

Light³

et al. 2013

AJP

146

104

View full text Add to dashboard Cite

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“…Anhedonia played an important role in psychopathology theories at the beginning of the twentieth century (Bleuler, 1911; Kraepelin, 1919; Myerson, 1923). In particular, Kraepelin (1919) spoke of anhedonia as a core symptom of a state of individual suffering, which was part of the dementia praecox.…”

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confidence: 99%

Anhedonia and Substance Dependence: Clinical Correlates and Treatment Options

Hatzigiakoumis¹,

Martinotti²,

et al. 2011

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Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, and it refers to both a state symptom in various psychiatric disorders and a personality trait. It has a putative neural substrate, originating in the dopaminergic mesolimbic and mesocortical reward circuit. Anhedonia frequently occurs in mood disorders, as a negative symptom in schizophrenia, and in substance use disorders. In particular, we focus our attention on the relationships occurring between anhedonia and substance use disorders, as highlighted by many studies. Several authors suggested that anhedonia is an important factor involved in relapse as well as in the transition from recreational use to excessive drug intake. In particular, anhedonia has been found to be a frequent feature in alcoholics and addicted patients during acute and chronic withdrawal as well as in cocaine, stimulant, and cannabis abusers. Furthermore, in subjects with a substance dependence disorder, there is a significant correlation between anhedonia, craving, intensity of withdrawal symptoms, and psychosocial and personality characteristics. Therefore treating anhedonia in detoxified alcohol-dependent subjects could be critical in terms of relapse prevention strategies, given its strong relationship with craving.

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“…This is especially challenging when experts disagree about what constitutes a particular symptom. Anhedonia is defined in the DSM-IV-TR as a loss of interest or pleasure (American Psychiatric Association, 2000), which arguably reflects the consensus use of the term over the past 100 or so years (e.g., Myerson, 1922; see also Berrios, 1996). However, the DSM-5 contains a new definition within the schizophrenia (not depression) chapter, "the decreased ability to experience pleasure from positive stimuli or a degradation in the recollection of pleasure previously experienced, " and arguments continue as to whether a broad or narrow use of the term is more helpful (recently discussed by DerAvakian and Markou, 2012;Romer Thomsen et al, 2015).…”

Section: Discussionmentioning

confidence: 99%