Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics

Beauchaine, Theodore P.; Klein, Daniel N.; Knapton, Erin; Zisner, Aimee R.

doi:10.1016/b978-0-12-813333-0.00005-6

Cited by 3 publications

(2 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dampened striatal responding while anticipating incentives is observed in ADHD, CD, SUDs, ASPD, unipolar depression, and nonsuicidal self-injury (Forbes et al, 2006;Holz et al, 2017;Kolla et al, 2015;Luijten, Schellekens, Kühn, Machielse, & Sescousse, 2017;Plichta & Scheres, 2014;Sauder, Derbidge, & Beauchaine, 2016; see also Beauchaine & Hinshaw, 2020;Forbes & Dahl, 2012;Zisner & Beauchaine, 2016 for recent reviews). Striatal under-responding, which is determined by both heritable and environmental influences (Birn, Roeber, & Pollak, 2017;Stokes et al, 2012), is a likely mechanism of negative emotionality/affectivity and the anhedonic, irritable mood state that cuts across the internalizing and externalizing spectra (see Beauchaine & Constantino, 2017;Beauchaine, Klein, Knapton, & Zisner, 2019;Beauchaine & Tackett, 2020;Laakso et al, 2003). Smaller striatal volumes are also observed in both internalizing and externalizing disorders (e.g., Matsuo et al, 2008;Wallace et al, 2014).…”

Section: Transdiagnostic and Differentiating Neuroaffective Mechanisms Of Comorbiditymentioning

confidence: 99%

Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study

2021

Self Cite

View full text Add to dashboard Cite

Despite nonoverlapping diagnostic criteria, internalizing and externalizing disorders show substantial comorbidity. This comorbidity is attributable, at least in part, to transdiagnostic neuroaffective mechanisms. Both unipolar depression and externalizing disorders are characterized by structural and functional compromises in the striatum and its projections to the anterior cingulate cortex (ACC) and other frontal regions. Smaller volumes and dampened reward responding in these regions are associated with anhedonia and irritability – mood states that cut across the internalizing and externalizing spectra. In contrast, smaller amygdala volumes and dampened amygdala function differentiate externalizing disorders from internalizing disorders. Little is known, however, about associations between internalizing–externalizing comorbidity and brain volumes in these regions, or whether such patterns differ by sex. Using a transdiagnostic, research domain criteria (RDoC)-informed approach, we evaluate associations between heterotypic (Internalizing × Externalizing) symptom interactions and striatal, amygdalar, and ACC volumes among participants in the Adolescent Brain Cognitive Development study (N = 6,971, mean age 9.9 years, 51.6% female). Heterotypic symptoms were associated with ACC volumes for both sexes, over and above the main effects of internalizing and externalizing alone. However, heterotypic comorbidity was associated with larger ACC volumes for girls, but with smaller ACC volumes for boys. These findings suggest a need for further studies and transdiagnostic assessment by sex.

show abstract

Section: Transdiagnostic and Differentiating Neuroaffective Mechanisms Of Comorbiditymentioning

confidence: 99%

Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…One of the most remarkable symptoms of MDD is anhedonia, an inability to experience pleasure with a response to stimulus and interest. It has been suggested that anhedonia, is related to the abnormality of the dopaminergic pathway of the reward system (Beauchaine, Klein, Knapton & Zisner, 2019). In 2009, By scanning the brain of MDD patients while conducting monetary incentive delay tasks, Functional magnetic resonance imaging studies showed that patients with MDD have a reduced ventral striatal volume in the reward system, which might indicate a reduction in dopaminergic receptors and dopamine synthesis (Pizzagalli et al, 2009).…”

Section: Dopamine (Da)mentioning

confidence: 99%

How Can We Use Neurotransmitters in Emotion and Reward System to Study Depression?

Zhang¹

2019

lijhls

View full text Add to dashboard Cite

Depression is the most common and widespread psychiatric disorder severely affecting people's lives at all ages. Factors from social, psychological, and biological aspects can contribute to depression, and many hypotheses are associated with biological factors involved in the aetiology of depression such as genes and neurotransmitters. As three monoamine neurotransmitters, dopamine, serotonin, and norepinephrine, are involved in the regulation of mood and motivation in emotion and reward system, the dysfunction of neurotransmitters of depressive patients can lead to their abnormal symptoms. This paper will discuss how the behaviour of these neurotransmitters has helped develop antidepressant drugs for treating depression. Although helpful, antidepressant drugs have other negative health outcomes on users such as side effects. Research on antidepressants has led to the development of new drugs such as nasal spray and skin patch which has shown to alleviate symptoms of depressive patients. Current treatments with a potential reduction of side effects are suggested on new applications for improving public health condition. Furthermore, other non-medical factors such as social engagement and physical activity are also involved in treating depression.

show abstract

RDoC and Psychopathology among Youth: Misplaced Assumptions and an Agenda for Future Research

Beauchaine

Hinshaw

2020

Journal of Clinical Child & Adolescent Psychology

View full text Add to dashboard Cite

Anhedonia in Depression: Mechanisms, Assessment, and Therapeutics

Cited by 3 publications

References 124 publications

Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study

Internalizing–externalizing comorbidity and regional brain volumes in the ABCD study

How Can We Use Neurotransmitters in Emotion and Reward System to Study Depression?

RDoC and Psychopathology among Youth: Misplaced Assumptions and an Agenda for Future Research

Contact Info

Product

Resources

About