Anhedonia in mood disorders and somatic diseases: results of exploratory Mendelian randomization analysis

Kasyanov, E. D.; Pinakhina, Daria; Rakitko, Alexander; Vergasova, Ekaterina; Yermakovich, Danat; Рукавишников, Г. В.; Malyshko, L V; Popov, Iaroslav; Kovalenko, Elena V.; Ilinskaya, Anna; Kim, Anna; Plotnikov, Nikolay; Незнанов, Н. Г.; Ilinsky, Valery; Кибитов, А.О.; Мазо, Г. Э.

doi:10.17116/jnevro202312304265

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…Gene annotation was performed using GeneCards (Weizmann Institute of Science, Israel 4 ). The methods are also described in our earlier article with the results of the Mendelian randomization analysis [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders

Kasyanov,

Pinakhina,

Rakitko

et al. 2024

Consortium Psychiatricum

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BACKGROUND: Anhedonia is characterized by a reduced ability to anticipate, experience, and/or learn about pleasure. This phenomenon has a transdiagnostic nature and is one of the key symptoms of mood disorders, schizophrenia, addictions, and somatic conditions. AIM: To evaluate the genetic architecture of anhedonia and its overlap with other mental disorders and somatic conditions. METHODS: We performed a genome-wide association study of anhedonia on a sample of 4,520 individuals from a Russian non-clinical population. Using the available summary statistics, we calculated polygenic risk scores (PRS) to investigate the genetic relationship between anhedonia and other psychiatric or somatic phenotypes. RESULTS: No variants with a genome-wide significant association were identified. PRS for major depression, bipolar disorder, and schizophrenia were significantly associated with anhedonia. Conversely, no significant associations were found between PRS for anxiety and anhedonia, which aligns well with existing clinical evidence. None of the PRS for somatic phenotypes attained a significance level after correction for multiple comparisons. A nominal significance for the anhedonia association was determined for omega-3 fatty acids, type 2 diabetes mellitus, and Crohn’s disease. CONCLUSION: Anhedonia has a complex polygenic architecture, and its presence in somatic diseases or normal conditions may be due to a genetic predisposition to mood disorders or schizophrenia.

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Section: Methodsmentioning

confidence: 99%

Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders

Kasyanov,

Pinakhina,

Rakitko

et al. 2024

Consortium Psychiatricum

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Association of anhedonia with comorbid mental disorders, suicidality and personality traits in patients with depression

Rukavishnikov,

Kasyanov,

Shishkovskaia

et al. 2023

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients

Szepietowska,

Stefaniak,

Krajewski

et al. 2024

CCID

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Background Anhedonia is defined as a reduced ability to experience or even a total loss of pleasure. Purpose This study was undertaken to evaluate anhedonia in 104 consecutive acne patients. Material and Methods Acne severity was assessed with Investigator Global Assessment (IGA), anhedonia was studied with the Snaith-Hamilton Pleasure Scale (SHAPS), Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) and Temporal Experience of Pleasure Scale (TEPS). Moreover, the quality of life (QoL) and stigmatization, as well as depression and anxiety (Hospital Anxiety and Depression Scale – HADS), were additionally evaluated. Results Anhedonia was found in 20.19% of acne patients and was more common (p=0.007) in males (34.29%) than in females (13.04%). Based on SHAPS, males with acne showed significantly (p=0.049) higher levels of anhedonia (2.39 ± 3.18 points) than acne females (1.26 ± 2.36 points). Anhedonia significantly correlated with the clinical acne severity (SHAPS: r=0.205, p=0.038 and ACIPS: r=−0.222, p=0.026). Although the intensity of anhedonia did not show any relationship with QoL and stigmatization assessments, there was a significant correlation between anhedonia and depressive symptoms (SHAPS: r=0.310, p<0.001; ACIPS: r=−0.364, p<0.001). Such dependency was not documented for anxiety. Conclusion Anhedonia seems to be a common phenomenon in acne and should be considered in the holistic approach to acne patients.

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Anhedonia in mood disorders and somatic diseases: results of exploratory Mendelian randomization analysis

Cited by 3 publications

References 51 publications

Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders

Genetic Associations of Anhedonia: Insights into Overlap of Mental and Somatic Disorders

Association of anhedonia with comorbid mental disorders, suicidality and personality traits in patients with depression

Anhedonia in Acne Vulgaris: A Cross-Sectional Study of 104 Consecutive Acne Patients

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