Anhedonia influences threat avoidance and relief: A conceptual replication

Leng, Lu; Beckers, Tom; Vervliet, Bram

doi:10.1016/j.xjmad.2024.100050

Journal of Mood & Anxiety Disorders

2024

DOI: 10.1016/j.xjmad.2024.100050

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Anhedonia influences threat avoidance and relief: A conceptual replication

Lu Leng,

Tom Beckers,

Bram Vervliet

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2024

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Cited by 3 publications

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Anhedonia is associated with overgeneralization of conditioned fear during late adolescence and early adulthood

Rosenberg,

Young,

Nusslock

et al. 2024

Journal of Anxiety Disorders

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Anhedonia is associated with overgeneralization of conditioned fear during late adolescence and early adulthood

Rosenberg,

Young,

Nusslock

et al. 2024

Journal of Anxiety Disorders

View full text Add to dashboard Cite

Reward processes in extinction learning and applications to exposure therapy

Rosenberg,

Barnes-Horowitz,

Zbozinek

et al. 2024

Journal of Anxiety Disorders

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Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology

Rosenberg,

Moreira,

Leal

et al. 2024

Dev Psychopathol

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Background: Reward and threat processes work together to support adaptive learning during development. Adolescence is associated with increasing approach behavior (e.g., novelty-seeking, risk-taking) but often also coincides with emerging internalizing symptoms, which are characterized by heightened avoidance behavior. Peaking engagement of the nucleus accumbens (NAcc) during adolescence, often studied in reward paradigms, may also relate to threat mechanisms of adolescent psychopathology. Methods: 47 typically developing adolescents (9.9–22.9 years) completed an aversive learning task during functional magnetic resonance imaging, wherein visual cues were paired with an aversive sound or no sound. Task blocks involved an escapable aversively reinforced stimulus (CS+r), the same stimulus without reinforcement (CS+nr), or a stimulus that was never reinforced (CS−). Parent-reported internalizing symptoms were measured using Revised Child Anxiety and Depression Scales. Results: Functional connectivity between the NAcc and amygdala differentiated the stimuli, such that connectivity increased for the CS+r (p = .023) but not for the CS+nr and CS−. Adolescents with greater internalizing symptoms demonstrated greater positive functional connectivity for the CS− (p = .041). Conclusions: Adolescents show heightened NAcc-amygdala functional connectivity during escape from threat. Higher anxiety and depression symptoms are associated with elevated NAcc-amygdala connectivity during safety, which may reflect poor safety versus threat discrimination.

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Anhedonia influences threat avoidance and relief: A conceptual replication

Cited by 3 publications

References 50 publications

Anhedonia is associated with overgeneralization of conditioned fear during late adolescence and early adulthood

Anhedonia is associated with overgeneralization of conditioned fear during late adolescence and early adulthood

Reward processes in extinction learning and applications to exposure therapy

Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology

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