Anhedonia predicts suicidal ideation in a large psychiatric inpatient sample

Winer, E. Samuel; Nadorff, Michael R.; Ellis, Thomas E.; Allen, Jon G.; Herrera, Steve; Salem, Taban

doi:10.1016/j.psychres.2014.04.016

Cited by 122 publications

(162 citation statements)

References 20 publications

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“…Initially, only symptoms of anhedonia, β = 0.12, p < 0.01, were associated with suicide risk, consistent with the previous finding that anhedonic symptoms of depression are related to suicidal ideation independent of cognitive and affective symptoms of depression. 49 After adding insomnia duration and nightmare duration to the regression in step two (R 2 change = 0.03, F = 3.44, p = 0.04), symptoms of anhedonia, β = 0.12, p < 0.01, and nightmare duration, β = 0.03, p = 0.01, were the only variables associated with suicide risk. Again, our hypothesis was partially supported.…”

Section: Resultsmentioning

confidence: 96%

Unpacking Sleep and Suicide in Older Adults in a Combined Online Sample

Golding

Nadorff

Winer

et al. 2015

Journal of Clinical Sleep Medicine

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BRIEF SUMMARYCurrent Knowledge/Study Rationale: Research has shown relations between duration of insomnia symptoms/duration of nightmares and suicide risk in younger adults. However, this relation has not been examined in older adults. Study Impact: The present study found that, in older adults, nightmare duration was related to suicide risk independent of current nightmares, current symptoms of and duration of insomnia, and symptoms of anhedonia and PTSD. Nightmare duration was also related to suicide risk independent of the IPTS. Thus, nightmare duration is an important factor to be assessed when evaluating the level of suicide risk with patients.Objective: Duration of insomnia symptoms and nightmares are related to suicidal risk in young adults independent of current symptoms of insomnia, nightmares, anxiety, depression, and PTSD. However, this relation has yet to be examined among older adults, despite older adults being at higher risk of suicidal behavior. Further, the current study aims to replicate previous research among younger adults showing that insomnia symptoms and nightmares are associated with suicide risk independent of the interpersonal psychological theory of suicide (IPTS). Methods: The present study utilized 167 participants age 55 and older obtained by combining two independent mTurk data collections of adults in the United States. Results: In the current sample, duration of nightmares was associated with suicide risk in older adults independent of symptoms of current insomnia and nightmares, duration of insomnia, and symptoms of PTSD, anhedonia, and the IPTS. Conclusions: Our fi ndings suggest that the duration of nightmares (i.e., how long someone has been experiencing nightmares) predict substantial variance in suicide risk among older adults in addition to the risk factors typically examined. S uicide is a leading cause of death, yet it remains a challenge to predict and prevent. In 2012, suicide was the tenth leading cause of death in the United States, accounting for 40,600 deaths.1 Further, 2012 marks the fi rst time in history that U.S. deaths by suicide have exceeded 40,000 in a year.2 Suicide is a particularly large problem for older adults: although older adults only made up about 13.7% of the population in 2012, older adults represented 16.4% of suicides.1 Suicidal intent, which refers to the degree to which one desires to end his/her life by suicidal behavior, 3 is more common in older adults than in the rest of the population, and attempts made by older adults are more likely to be fatal. 4 To illustrate this, there are 100-200 attempts for every one youth suicide and 4 attempts for every one older adult suicide.5 Thus, older adult suicide attempts are much more likely to be fatal than younger adult suicide attempts. Research has identifi ed many risk factors for older adult suicide including the loss of independence, social isolation, mental illness, and decline in physical health. 4,[6][7][8] However, despite having identifi ed these risk factors, clinicians are still very po...

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Section: Resultsmentioning

confidence: 96%

Unpacking Sleep and Suicide in Older Adults in a Combined Online Sample

Golding

Nadorff

Winer

et al. 2015

Journal of Clinical Sleep Medicine

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“…However, the replication and extension of previous patterns of findings evidenced with clinical samples (Nock & Kazdin, 2002;Winer, Nadorff, et al, 2014) somewhat offsets these limitations. Furthermore, the measure of anhedonia used in this study allowed for an examination of recent changes in anhedonia, yielding a cross-sectional analysis that was highly specific regarding the timeframe in question.…”

Section: Limitationsmentioning

confidence: 87%

“…Thus, we wished to examine whether (a) anhedonia was uniquely associated with suicidal ideation, as previously found in the literature (Nock & Kazdin, 2002;Winer, Nadorff, et al, 2014;Xie et al, 2014), and whether (b) anhedonia was uniquely associated with suicide attempts. To investigate the unique elements of anhedonia, we examined the relationship between anhedonia, suicidal ideation, and suicide attempts while holding other symptoms of depression constant.…”

mentioning

confidence: 94%

“…Anhedonia, or the loss of interest and/or pleasure in people or things, has recently received increased empirical and theoretical investigation (Treadway, Bossaller, Shelton, & Zald, 2012;Wardle, Treadway, Mayo, Zald, & de Wit, 2011;Winer, Veilleux, & Ginger, 2014), with recent evidence suggesting that anhedonia may be a unique predictor of psychopathology (Winer, Veilleux, et al, 2014), including suicidality (Nock & Kazdin, 2002;Winer, Nadorff, et al, 2014;Xie et al, 2014). For example, a recent study examining the relationship between anhedonia and suicidal ideation found that the level of anhedonia at baseline, as well as changes in anhedonia over time, predicted suicidal ideation at termination within a sample of 1,529 clinical inpatients, when holding constant (a) baseline suicidality and (b) cognitive symptoms of depression .…”

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confidence: 99%

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The Association between Anhedonia, Suicidal Ideation, and Suicide Attempts in a Large Student Sample

Winer¹,

Drapeau

Veilleux

et al. 2015

Archives of Suicide Research

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Depression is a significant risk factor for suicide. Evidence suggests that anhedonia may be a symptom of depression that is uniquely associated with suicidality. However, exactly how anhedonia is related to suicide is unclear. To provide more specific evidence regarding this association, we investigated relationships between anhedonia, suicidal ideation, and suicide attempts. A large combined undergraduate sample completed the novel Specific Loss of Interest and Pleasure Scale (SLIPS), the Center of Epidemiological Studies Depression Scale (CES-D), and the Suicidal Behaviors Questionnaire-Revised (SBQ-R). Anhedonia was associated with suicidal ideation, even when accounting for depressive symptoms. Additionally, anhedonia was not associated with suicide attempts when symptoms of depression were held constant. The current study provides novel evidence regarding the relationship between anhedonia and risk of attempting suicide. Future research can examine the role anhedonia plays in the unfolding of suicidal behavior over time.

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“…Notably, the presence and saliency of certain depressive symptoms have been differentially associated with clinical outcomes, including treatment resistant depression and risk of suicide attempts. For example, high anhedonia in particular is strongly linked to suicidality and poor response to treatment (Downar et al, 2014; Spijker, de Graaf, Ten Have, Nolen, & Speckens, 2010; Winer et al, 2014). Similarly, depressed mood, including feelings of guilt and unworthiness, has been linked to suicide attempts (Nrugham, Larsson, & Sund, 2008; Oquendo et al, 2004) and completion (McGirr et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Ventral Striatum Functional Connectivity during Rewards and Losses and Symptomatology in Depressed Patients

Quevedo

Scott

et al. 2017

Biological Psychology

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BACKGROUND The ventral striatum (VS) and striatal network supports goal motivated behavior. Identifying how depressed patients differ in their striatal network during the processing of emotionally salient events is a step towards uncovering biomarkers for diagnosis and treatment. METHODS 38 depressed and 30 healthy adults completed a task that examined brain activation to the anticipation and receipt of monetary rewards and losses. Data were collected using a 3T Siemens Trio scanner. Functional connectivity differences were examined with seeds in the Left or Right VS. FC estimates were regressed on specific symptoms. RESULTS Depressed patients displayed higher functional connectivity between the VS and midline cortical areas during loss versus reward trials. Anhedonia and depressed mood were associated to fairly similar striatal circuits but suicidality was associated to a unique VS-midline structures coupling, while depression severity was linked to higher VS to caudate and precuneus connectivity during loss versus reward trials. CONCLUSIONS Depression is characterized by excessive VS coupling to cognitive control and associative networks during losses versus rewards. High VS to midline cortical structures coupling may index suicidality.

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Anhedonia predicts suicidal ideation in a large psychiatric inpatient sample

Cited by 122 publications

References 20 publications

Unpacking Sleep and Suicide in Older Adults in a Combined Online Sample

Unpacking Sleep and Suicide in Older Adults in a Combined Online Sample

The Association between Anhedonia, Suicidal Ideation, and Suicide Attempts in a Large Student Sample

Ventral Striatum Functional Connectivity during Rewards and Losses and Symptomatology in Depressed Patients

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