Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression

Géa, Luíza Paul; Colombo, Rafael; Rosa, Eduarda Dias da; Antqueviezc, Bárbara; Aguiar, Érica Z de; Hizo, Gabriel Henrique; Schmidt, Gabriela Barella; Oliveira, Larissa Fagundes de; Stein, Dirson João; Rosa, Adriane Ribeiro

doi:10.1016/j.bbr.2019.112076

Cited by 24 publications

(11 citation statements)

References 57 publications

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“…68 Thus, hypertrophy of the adrenal gland was observed. 69 In the present investigation, increased adrenal activity as shown by increased adrenal weight in ligatured rats indicate the activation of the HPA axis. Nonetheless, normal weight of adrenal gland in rats treated by S. coronopifolius extract alone or combined with BCG indicated that these treatments prevented the depression-induced activation of adrenocortical activity.…”

Section: G L I G L I G + a E L I G + A E L I G + A E L I G + B C G supporting

confidence: 56%

Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats

Fellah

Djenidi

Chebout

2020

Psychiatry Investig

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Objective Immunomodulation is a therapeutic technique that modulates the balance of cytokines in the body. In this regard, our experiment was conducted to investigate the potential effect of S. coronopifolius crude extract in combination with low dose of Bacillus Calmette-Guerin (BCG) on depression-like behaviors in female Wistar rats.Methods Sciatic nerve injury was employed to induce depression and intradermal injection of 0.02 mL of BCG per rat was administered to lead an activation of innate immune system. Daily intra-peritoneal injections of 25 mg algae extract kg-1 body weight were performed for 14 continuous days. Forced Swimming (FS) and Open Field (OF) tests were conducted to assess despairing and spontaneous behaviors. At the end of the experiment, brain was removed to determine the activities of catalase (CAT) and glutathione-S-transferase (GST), whereas spleen and adrenals were used for the histopathological study.Results The combined treatment exhibited antidepressant-like activity in FST by reducing immobility time, without inducing any significant change in ambulatory behavior in OFT. The histological analyses of spleen and adrenal structure showed a conserved architecture.Conclusion The results suggested that algae extract produce an antidepressant-like effect in combination with low dose of BCG, which is possibly trigged by its anti-oxidant and anti-inflammatory properties.

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Section: G L I G L I G + a E L I G + A E L I G + A E L I G + B C G supporting

confidence: 56%

Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats

Fellah

Djenidi

Chebout

2020

Psychiatry Investig

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“…Among them, depression, anxiety, cognitive impairment, and posttraumatic stress disorder related symptoms are the main components of psychological PICS [2,3,8,19,20]. Using a translational mouse model of PICS, we have recently shown that combined immune challenge with LPS and subsequent chronic stress induces synergistic pathological effects on behavioral outcomes [9], which were consistent with one recent study in which they showed depressive-like behavior in a two-hit model of depression by using LPS injection and subsequent chronic unpredictable mild stress protocol [21]. In the present study, we confirmed our previous finding that this two-hit hypothesis model of PICS displayed reproducible anxiety-and depression like behavior and cognitive impairments, suggesting this model is reliable.…”

Section: Discussionsupporting

confidence: 83%

Parvabumin interneuron-mediated hippocampal network activity disruption in a two-hit model with relevance to postintensive care syndrome: prevention by fluoxetine

Ji¹,

Tong²,

Zhou³

et al. 2020

Preprint

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Background Postintensive care syndrome (PICS) is defined as a new or worsening impairment in cognition, mental health, and physical function after critical illness, which is associated with reduced quality of life and increased mortality. We recently have developed a clinically relevant animal model of PICS, which can mimic most features of human PICS. However, the underlying mechanism remains largely to be elucidated. Accumulating evidence has suggested that hippocampal GABAergic interneuron dysfunction is implicated in various mood disorders induced by stress. Methods We explored the role of hippocampal GABAergic interneurons and relevant neural activities in an animal model of PICS based on two-hit hypothesis. In addition, we tested whether fluoxetine treatment early following combined stress can prevent subsequent anatomical and behavioral pathologies. Results Here our study further supported our previous findings that this PICS model displayed reproducible anxiety- and depression like behavior and cognitive impairments, which resembles clinical features of human PICS. This behavioral state is accompanied by hippocampal neuroinflammation, reduced parvalbumin (PV) expression, and decreased theta and gamma power. Importantly, chronic fluoxetine treatment reversed most of these abnormities. Conclusions Our study provides additional evidence that PV interneuron-mediated hippocampal network activity disruption might play a key role in the pathological of PICS, while fluoxetine offers protection via modulation of the hippocampal PV interneuron and relevant network activities.

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“…Cytokines released in response to LPS administration appear to significantly influence cognitive processes and motor performance due to the effects on neurotransmitter systems [24, 26, 34]. In addition, the increase in IFN-γ levels induced by the administration of LPS is correlated with the depressive-like behavior presented in these models [35].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Brain Cytokines and the Level of Brain-Derived Neurotrophic Factor in an Inflammatory Model of Depression

Horita

Silva

Ferrari

et al. 2020

Neuroimmunomodulation

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Introduction: Major depressive disorder is considered a global public health problem. Inflammatory processes are likely involved in its pathophysiology, but the underlying mechanisms have remained uncertain.Here, we used the model of systemic lipopolysaccharide (LPS) injection to test the hypothesis that depressive-like behaviors occur along with changes in the levels of cytokines and brain-derived neurotrophic factor (BDNF) in the hippocampus (HC), prefrontal cortex (PFC), and hypothalamus (HT), and can be prevented by dexamethasone administration. Methods: Adult C57Bl/6 male mice were first isolated for 10 days, and thereafter received an injection of dexamethasone (6 mg/kg, intraperitoneal [i.p.]), saline followed by LPS (0.83 mg/kg, i.p.), or saline. After 6 h, animals were subjected to the forced-swim test (FST) and open-field tests. Immediately after the behavioral tests, they were euthanized and their brains were collected for the biochemical analyses. Results: LPS increased the immobility time and reduced the distance travelled in the FST and open-field test, respectively. Dexamethasone increased the immobility time in saline-treated mice but reduced this behavior in the LPS group. LPS increased the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and interferon (IFN)-γ in most of the regions evaluated. Dexamethasone prevented LPS-induced IL-6 in the HC, PFC, and HT. Interestingly, dexamethasone increased IL-4 and IL-10 levels in both the LPS- and saline-treated groups. Although dexamethasone reduced BDNF in saline-treated mice, it prevented LPS-induced reduction in this neurotrophic factor. Conclusion: In summary, dexamethasone decreased proinflammatory and increased anti-inflammatory levels of cytokines and prevented a reduction in BDNF levels induced by the inflammatory stimulus. Thus, the attenuation of depressive-like behavior induced by dexamethasone may be related to the effects on these parameters.

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Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression

Cited by 24 publications

References 57 publications

Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats

Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats

Parvabumin interneuron-mediated hippocampal network activity disruption in a two-hit model with relevance to postintensive care syndrome: prevention by fluoxetine

Evaluation of Brain Cytokines and the Level of Brain-Derived Neurotrophic Factor in an Inflammatory Model of Depression

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