Patai's Chemistry of Functional Groups 2009
DOI: 10.1002/9780470682531.pat0383
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Anilines: Historical Background

Abstract: Introduction Identifying Aniline The Aniline Dyes Technology Transfer Azo Dyes and their Intermediates Patent Law in G ermany Aniline Red and the Structures of Aniline Dyes Contributions to Academic Chemistry … Show more

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Cited by 4 publications
(3 citation statements)
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“…Aromatic amines (anilines) are key nitrogen-containing building blocks for the production of pharmaceuticals, dyes, and polymers, with a prime example being the synthesis of paracetamol, a derivative of 4-aminophenol. Typically, aromatic amines are synthesized through the reduction of the corresponding nitroarene compounds using heterogeneous catalysts at elevated temperatures and pressures and employing hydrogen gas as the reductant. , Although these conditions give good results for the reduction of unfunctionalized nitrobenzene to aniline, the reduction of more complex (substituted) nitroarenes to their aniline products is much more difficult to achieve with high selectivity. , From among the substituted nitroarenes with reducible groups (e.g., carbonyls, esters, amines, and halide groups), the most challenging substrates are the halogenated aromatics, as the hydro-dehalogenation reaction can occur very readily under the standard high temperature and pressure reduction conditions, leading to a marked drop in selectivity. …”
Section: Introductionmentioning
confidence: 99%
“…Aromatic amines (anilines) are key nitrogen-containing building blocks for the production of pharmaceuticals, dyes, and polymers, with a prime example being the synthesis of paracetamol, a derivative of 4-aminophenol. Typically, aromatic amines are synthesized through the reduction of the corresponding nitroarene compounds using heterogeneous catalysts at elevated temperatures and pressures and employing hydrogen gas as the reductant. , Although these conditions give good results for the reduction of unfunctionalized nitrobenzene to aniline, the reduction of more complex (substituted) nitroarenes to their aniline products is much more difficult to achieve with high selectivity. , From among the substituted nitroarenes with reducible groups (e.g., carbonyls, esters, amines, and halide groups), the most challenging substrates are the halogenated aromatics, as the hydro-dehalogenation reaction can occur very readily under the standard high temperature and pressure reduction conditions, leading to a marked drop in selectivity. …”
Section: Introductionmentioning
confidence: 99%
“…Given the importance of amine molecules in natural products [1] and drug molecules, [2] numerous approaches have been developed for their synthesis. [3] The CÀNb ond-formingr eaction has attracted the interest of synthetic chemists since the last century because the introduction of amino groups can help tune the physicochemical properties of molecules andl ead to biologicallyi mportant structures.…”
Section: Introductionmentioning
confidence: 99%
“…Among heterogeneous catalysts, supported Rh complexes have been widely employed for promoting hydrogenation reactions [8,9,10,11]. In the field of the hydrogenation of unsaturated compounds the catalytic hydrogenation of aromatic halonitro compounds to yield anilines is very important, since haloanilines are a class of industrially interesting compounds used as starting materials or intermediates of many fine chemicals, such as dyes, drugs, herbicides, cosmetic products, pesticides and polymers [12,13]. The catalysts usually employed in the hydrogenation of halonitroarenes are based on transition metals [14], such as noble metals and Raney nickel, which is very sensitive toward the moisture in air and may burn.…”
Section: Introductionmentioning
confidence: 99%