Animal Health: Global Antibiotic Issues

Peng, Mengfei; Biswas, Debabrata

doi:10.1016/b978-0-444-52512-3.00187-x

Cited by 30 publications

(24 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Animal agriculture, particularly poultry and swine farming in developed countries, accounts for more than half of the antibiotics used in the world (7,8). Antibiotics are used in animal farming both for treating diseases (therapeutic) and for growth promotion (subtherapeutic) (9). Subtherapeutic dosages of antibiotics in animal feed/water induce faster weight gain via inhibition/modulation of the normal microbiota, leading to increased nutrient utilization and a reduction in the maintenance costs of the gastrointestinal (GI) system due to decreased inflammation (10,11).…”

mentioning

confidence: 99%

“…Subtherapeutic dosages of antibiotics in animal feed/water induce faster weight gain via inhibition/modulation of the normal microbiota, leading to increased nutrient utilization and a reduction in the maintenance costs of the gastrointestinal (GI) system due to decreased inflammation (10,11). Furthermore, subtherapeutic dosage of antibiotics makes additional contributions to animal agriculture by improving animal health and welfare and control of human foodborne infectious diseases by reducing crosscontamination and extending the shelf life of products (9,12).…”

mentioning

confidence: 99%

“…In addition to subtherapeutic dosages of antibiotics, significant amounts of therapeutic antibiotics are used in food animals to treat clinical diseases or, prophylactically, to prevent common diseases (9). So far, very little attention, other than the data generated from in vitro laboratory studies, has been paid to how dosages of antibiotics used in farm animal production contribute to the overall problem of antibiotic resistance (8,13).…”

mentioning

confidence: 99%

“…It is well known that pasture/organic farming cannot meet the demand for animal products for seven billion people. Furthermore, solely blocking or withdrawing subtherapeutic antibiotic use in animal farming without controlling therapeutic or higher doses of antibiotics and use of other chemicals might not be enough to mitigate the threat of rising rates of antibiotic-resistant zoonotic pathogenic bacteria (9,25,26). According to published data from the Centers for Disease Control and Prevention (CDC), multidrug resistance in Salmonella accounts for approximately 6,200 cases (10% of total) of Salmonella infections each year in the United States.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Alterations of Salmonella enterica Serovar Typhimurium Antibiotic Resistance under Environmental Pressure

Peng

Biswas

Buchanan

2018

Appl Environ Microbiol

View full text Add to dashboard Cite

Microbial horizontal gene transfer is a continuous process that shapes bacterial genomic adaptation to the environment and the composition of concurrent microbial ecology. This includes the potential impact of synthetic antibiotic utilization in farm animal production on overall antibiotic resistance issues; however, the mechanisms behind the evolution of microbial communities are not fully understood. We explored potential mechanisms by experimentally examining the relatedness of phylogenetic inference between multidrug-resistant serovar Typhimurium isolates and pathogenic Typhimurium strains based on genome-wide single-nucleotide polymorphism (SNP) comparisons. Antibiotic-resistant Typhimurium isolates in a simulated farm environment barely lost their resistance, whereas sensitive Typhimurium isolates in soils gradually acquired higher tetracycline resistance under antibiotic pressure and manipulated differential expression of antibiotic-resistant genes. The expeditious development of antibiotic resistance and the ensuing genetic alterations in antimicrobial resistance genes in Typhimurium warrant effective actions to control the dissemination of antibiotic resistance. Antibiotic resistance is attributed to the misuse or overuse of antibiotics in agriculture, and antibiotic resistance genes can also be transferred to bacteria under environmental stress. In this study, we report a unidirectional alteration in antibiotic resistance from susceptibility to increased resistance. Highly sensitive serovar Typhimurium isolates from organic farm systems quickly acquired tetracycline resistance under antibiotic pressure in simulated farm soil environments within 2 weeks, with expression of antibiotic resistance-related genes that was significantly upregulated. Conversely, originally resistant Typhimurium isolates from conventional farm systems lost little of their resistance when transferred to environments without antibiotic pressure. Additionally, multidrug-resistant Typhimurium isolates genetically shared relevancy with pathogenic Typhimurium isolates, whereas susceptible isolates clustered with nonpathogenic strains. These results provide detailed discussion and explanation about the genetic alterations and simultaneous acquisition of antibiotic resistance in Typhimurium in agricultural environments.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Alterations of Salmonella enterica Serovar Typhimurium Antibiotic Resistance under Environmental Pressure

Peng

Biswas

Buchanan

2018

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…On the other hand, traditional antibiotic therapy has been found to lyse enterohemorrhagic E. coli (EHEC) which further increases the risk for post infectious sequelae Hemolyticuremic syndrome (HUS) in the patients [15,16]. In such situations, procommensal strategies by application of probiotics, prebiotics, and synbiotics can be considered as priority in prevention and treatment of foodborne such bacterial pathogen-induced enteric illness [11,17,18]. With a promising scheme, it allows an establishment or recovery of the healthy enteric microbial ecosystem by introducing native, exogenous, or genetically engineered beneficial probiotics without inducing deleterious effects (like antibiotics) on human commensal gut bacteria [14,19].…”

Section: Introductionmentioning

confidence: 99%

Prevention of enteric bacterial infections and modulation of gut microbiota composition with conjugated linoleic acids producingLactobacillusin mice

Peng

Tabashsum

Patel

et al. 2019

Preprint

View full text Add to dashboard Cite

25Probiotics are recognized to outcompete pathogenic bacteria by receptor-mediated 26 colonizing and secreting functional metabolites which have direct antimicrobial activities 27 towards pathogens and/or improving host's gut health and immunity. We have constructed 28 a Lactobacillus casei (LC) probiotic strain, LC +mcra , by inserting mcra (myosin cross-29 reactive antigen) gene, which stimulates the conversion of conjugated linoleic acids. In this 30 study, we evaluated the protective roles of LC +mcra against pathogenic Salmonella enterica 31 serovar Typhimurium (ST) and enterohaemorrhagic E. coli (EHEC) infection in BALB/cJ 32 mice. Through a series of in vivo investigation, we observed that LC +mcra colonized 33 efficiently in mice gut and competitively reduced the infection with ST and EHEC in 34 various locations of small and large intestine, specifically cecum, jejunum, and ileum 35 (p<0.05). The cecal microbiota in ST-challenged mice with LC +mcra protection were 36 positively modulated with higher relative abundances Firmicutes but lower Proteobacteria 37 plus increased bacterial species diversity/richness based on 16S metagenomic sequencing. 38 Based on cytokine gene expression analysis by qRT-PCR, mice pretreated with LC +mcra 39 were found with attenuated bacterial pathogen-induced gut inflammation. Furthermore, 40 mice fed LC +mcra daily for one week could protect themselves from the impairments caused 41 by enteric infections with ST or EHEC. These impairments include weight loss, negative 42 hematological changes, intestinal histological alterations, and potential death. This in vivo 43 study suggests that daily consumption of novel conjugated linoleic acids over-producing 44 probiotic might be efficient in improving gut intestinal microbiome composition and 45 preventing/combating foodborne enteric bacterial infections with pathogenic Salmonella 46 and diarrheagenic E. coli. 3 47 48Author summary 49 Numerous bacteria colonize throughout the gastrointestinal tract and form a complex 50 microbial ecosystem known as gut microbiota. A balanced microbial composition is crucial 51 for maintaining proper gut health and host defense against pathogenic microbes. However, 52 enteric bacterial infections could cause illness and even lead to death of host when 53 foodborne pathogens like Salmonella and enterohaemorrhagic E. coli (EHEC) invade gut 54 intestine and cause imbalance of gut microbiota. Beneficial microbes in gastrointestinal 55 tract such as Lactobacillus and their secreted bio-active metabolites, are potential bio-56 agents to improve gut immunity and outcompete bacterial pathogens. In this study, to 57 evaluate roles of novel Lactobacillus strain LC +mcra which produce higher amount of a 58 group of beneficial secondary metabolites called conjugated linoleic acids, we have shown 59 that daily oral administration of this LC +mcra for one-week in mice lead to higher proportion 60 of beneficial bacterial colonization in different locations of intestine and a significant 61 reduction of path...

show abstract

Antimicrobials in Livestock Production and Its Cross-Domain Dynamics

Pokharel

Karna

2022

Emerging Modalities in Mitigation of Antimicrobial Resistance

View full text Add to dashboard Cite

Animal Health: Global Antibiotic Issues

Cited by 30 publications

References 57 publications

Alterations of Salmonella enterica Serovar Typhimurium Antibiotic Resistance under Environmental Pressure

Alterations of Salmonella enterica Serovar Typhimurium Antibiotic Resistance under Environmental Pressure

Prevention of enteric bacterial infections and modulation of gut microbiota composition with conjugated linoleic acids producingLactobacillusin mice

Antimicrobials in Livestock Production and Its Cross-Domain Dynamics

Contact Info

Product

Resources

About