Animal mitochondrial DNA recombination revisited

Rokas, Antonis; Ladoukakis, Emmanuel D.; Ζούρος, Ε.

doi:10.1016/s0169-5347(03)00125-3

Cited by 252 publications

(184 citation statements)

References 69 publications

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“…In hybrid zones, heteroplasmy could be promoted by the lack of incomplete reproductive isolation (Rokas et al 2003). The geographic distribution of mitotypes in this study suggests that some mitochondrial forms could be the product of recombination mediated by heteroplasmy in the zone of contact between black spruce and red spruce.…”

Section: Discussionmentioning

confidence: 68%

“…It has been hypothesized that recurrent hybridization events, such as those observed in the zones of contact between closely related species, could provide the opportunity for heteroplasmy and recombination to occur (Rokas et al 2003). In hybridizing species, the reproductive barriers are not completely developed, and in some cases, the mechanisms inducing the elimination of male mitochondria could have broken down, leading to the leakage of paternal mitochondria and to transient heteroplasmy (e.g., Wagner et al 1991).…”

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confidence: 99%

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Mitochondrial Genome Recombination in the Zone of Contact Between Two Hybridizing Conifers

Jaramillo‐Correa

Bousquet

2005

Genetics

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Variation in mitochondrial DNA was surveyed at four gene loci in and around the zone of contact between two naturally hybridizing conifers, black spruce (Picea mariana) and red spruce (P. rubens) in northeastern North America. Most of the mtDNA diversity of these species was found in populations next to or into the zone of contact, where some individuals bore rare mitotypes intermediate between the common mitotypes observed in the allopatric areas of each species. Sequence analysis and tests for mtDNA recombination point to this phenomenon, rather than to recurrent mutation, as the most tenable hypothesis for the origin of these rare mitotypes. From the 10 mitotypes observed, at least 4 would be the product of recombination between 4 of the 5 putative ancestral mitotypes. Tests for cytonuclear disequilibrium and geographical structure of the putative recombinant mitotypes suggest that mtDNA recombination is not frequent and relatively recent on the geological time scale. mtDNA recombination would have been promoted by transient heteroplasmy due to leakage of paternal mtDNA since the Holocene secondary contact between the two species.

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Section: Discussionmentioning

confidence: 68%

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confidence: 99%

Mitochondrial Genome Recombination in the Zone of Contact Between Two Hybridizing Conifers

Jaramillo‐Correa

Bousquet

2005

Genetics

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“…Typically, identical copies of mtDNA sequences in animals (known as homoplasmy) (Birky, 2001) serve as a crucial assumption in population genetic studies based on mtDNA, even though mitochondrial heteroplasmy and recombination may be more common than previously thought (Rokas et al, 2003;Barr et al, 2005). One mechanism leading to heteroplasmy, doubly uniparental inheritance has been found in many bivalves (Saavedra et al, 1997;Breton et al, 2007;Theologidis et al, 2008;Dégletagne et al, 2016) where genetically distinct male and female mitochondrial lineages exist.…”

Section: Discussionmentioning

confidence: 99%

Population genetic structure of Calanoides natalis (Copepoda, Calanoida) in the eastern Atlantic Ocean and Benguela upwelling system

Höring¹,

Cornils²,

Auel³

et al. 2017

Journal of Plankton Research

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The population genetic structure of Calanoides natalis (ex Calanoides carinatus; Copepoda, Calanoida), an ecologically important component of African upwelling systems, was studied in order to (i) search for potential cryptic species, (ii) describe spatial patterns in the distribution of genetic variance and (iii) identify potential barriers to gene flow. Samples were obtained in the eastern Atlantic Ocean from the Iberian Peninsula to Namibia. Analysis of mitochondrial (cytochrome c oxidase subunit I; COI) and nuclear (citrate synthase; CS) marker genes revealed a genetically cohesive population of C. natalis with a prevalent shift in allele frequencies. The discovery of a deep split solely present in the mitochondrial dataset does not point to cryptic speciation, but rather suggests the occurrence of nuclear mitochondrial pseudogenes or incomplete reproductive isolation upon secondary contact. Genetic differentiation between the northern and southern hemisphere was significant, which may point to a potential, but permeable barrier close to the equator. No vertical genetic structuring was detected in the northern Benguela implying that horizontal differentiation was more pronounced than vertical structuring. Retention mechanisms and the oxygen minimum zone did not have a strong impact on genetic differentiation of C. natalis in the Benguela region.

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“…The extent of the effect of recombination on animal mtDNA variability remains an open question (see for review Rokas et al, 2003). As in other mammals, mtDNA recombination is thought to be absent in cattle, yet mitofusins (Entrez GeneIDs: 515180; 534574), which catalyze mitochondrial fusion, are present in the bovine genome, as are the enzymes for mtDNA recombination that are part of the mtDNA repair and replication machinery, such as bovine DNA ligase III (LIG3, Entrez GeneID: 514719).…”

Section: Discussionmentioning

confidence: 99%

Bovine mtDNA D-loop haplotypes exceed mutations in number despite reduced recombination: an effective alternative for identity control

Seroussi

Yakobson

2010

Animal

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Mitochondrial (mt) DNA D-loop heterogeneity, haplotype distribution and possible sub-population structures within the relevant populations are important for DNA-based traceability. To gain insight into this distribution, we compared 1515 Bos taurus mtDNA D-loop sequences available from GenBank to 219 sequences that we sequenced de novo. A pronounced ambiguous trace typical of C-track length heteroplasmy was encountered in 5% of the samples, which were excluded from the analysis. Previously undescribed mutations and haplotypes were observed in 6% and 63% of the sequences, respectively. B. taurus haplotypes divided into the taurus, indicus and grunniens types and 302 variable sites formed the 858 taurus haplotypes detected. Fifty-five sites displayed a complex level of variation. As each level represents an independent mutation event, a total of 399 mutations were traced, which could potentially explain independent formation of less than half (47%) of the haplotypes encountered: most haplotypes were derived from different combinations of these mutations. We suggest that a mutational hotspot may explain these results and discuss the usefulness of mtDNA for identity and maternity assurance.

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Animal mitochondrial DNA recombination revisited

Cited by 252 publications

References 69 publications

Mitochondrial Genome Recombination in the Zone of Contact Between Two Hybridizing Conifers

Mitochondrial Genome Recombination in the Zone of Contact Between Two Hybridizing Conifers

Population genetic structure of Calanoides natalis (Copepoda, Calanoida) in the eastern Atlantic Ocean and Benguela upwelling system

Bovine mtDNA D-loop haplotypes exceed mutations in number despite reduced recombination: an effective alternative for identity control

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