Animal Model of Human Cancer: Malignant Lymphoma/Colon Cancer/Lung Cancer/Liver Cancer/Brain Tumors/Skin Cancer

Karakurt, Serdar; Durmus, Irem Mukaddes; Erturk, Sureyya; Akalin, Halime Seyma; Bas, Kemal

doi:10.1007/978-981-19-3824-5_13

Cited by 1 publication

(1 citation statement)

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“…CRC induced by MNU or MNNG contains Kras (5-30%) and Apc (6%) mutations; nevertheless, the complete molecular profile of mutations caused by these carcinogens is still unknown [66][67][68]. Since i.r.…”

Section: Alkylating Substancesmentioning

confidence: 99%

Experimental Murine Models for Colorectal Cancer Research

Neto

Rocha

Gaspar

et al. 2023

Cancers

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Colorectal cancer (CRC) is the third most prevalent malignancy worldwide and in both sexes. Numerous animal models for CRC have been established to study its biology, namely carcinogen-induced models (CIMs) and genetically engineered mouse models (GEMMs). CIMs are valuable for assessing colitis-related carcinogenesis and studying chemoprevention. On the other hand, CRC GEMMs have proven to be useful for evaluating the tumor microenvironment and systemic immune responses, which have contributed to the discovery of novel therapeutic approaches. Although metastatic disease can be induced by orthotopic injection of CRC cell lines, the resulting models are not representative of the full genetic diversity of the disease due to the limited number of cell lines suitable for this purpose. On the other hand, patient-derived xenografts (PDX) are the most reliable for preclinical drug development due to their ability to retain pathological and molecular characteristics. In this review, the authors discuss the various murine CRC models with a focus on their clinical relevance, benefits, and drawbacks. From all models discussed, murine CRC models will continue to be an important tool in advancing our understanding and treatment of this disease, but additional research is required to find a model that can correctly reflect the pathophysiology of CRC.

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Section: Alkylating Substancesmentioning

confidence: 99%