Animal model of human medulloblastoma: Clinical, magnetic resonance imaging, and histopathological findings after intra-cisternal injection of MHH-MED-1 cells into nude rats

Valproic Acid Prolongs Survival Time of Severe Combined Immunodeficient Mice Bearing Intracerebellar Orthotopic Medulloblastoma Xenografts

“…Injection of a medulloblastoma cell line (MHH-MED-1) into the cistern magna of nude rats has also been reported (34). Because human medulloblastomas normally occur in cerebellum, some researchers have started to inject medulloblastoma cells into mouse cerebellum.…”

Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma

“…Stereotactic implantation of glioma cells into the rodent brain has been a widely used tool for glioma research, although the development of models specifically in the brainstem has lagged behind those of the cerebral cortex. The first demonstration that heterotopic cells could grow in the rodent brainstem came from the injection of human medulloblastoma cells into the cisterna magna of nude rats, which led to tumor cell colonization in the medulla and pons ( 22 ). This suggested that modeling glioma in the brainstem of rodents might be a feasible experimental approach for studying the biology and treatment of DIPG, and led others to investigate this further using adult and neonatal rodents.…”

MRI Detection of Early Bone Metastases in B16 Mouse Melanoma Models

“…Similarly, higher static magnetic fields (e.g., 4.7-11.74 T) and the use of small, high-sensitivity RF coils help to achieve the necessary sensitivity for imaging animals. Small-animal MRI has recently been applied to the development of animal models of cancer in brain [12][13][14], lung [15,16], kidney [17], bladder [18], prostate [19,20], and pancreas [21], as well as primary central nervous system lymphoma [22]. In a similar manner, MRI can be used to monitor the effects of cancer therapy in a wide variety of animal tumor models.…”