Animal Models

Venuto, Rocco C.; Lindheimer, Marshall D.

doi:10.1016/b978-0-12-374213-1.00010-0

Cited by 2 publications

(3 citation statements)

References 162 publications

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“…When subjected to reduced uteroplacental blood flow, these animals develop findings that mimic those seen in preeclamptic women. Sustained hypertension, proteinuria, and glomerular endotheliosis, the renal lesion that characterizes preeclampsia, have all been reported in these laboratory animals following uterine constriction of blood flow [ 12 ].…”

Section: Classification Of Hypertensive Disorders Of Pregnancymentioning

confidence: 99%

“…Nitric oxide synthesis is increased in women undergoing physiologic pregnancy, whereas analysis of tissue and urine samples strongly suggest that nitric oxide production is impaired in preeclamptic women. In laboratory animals nitric oxide synthase inhibition can produce a condition, which bears many similarities to preeclampsia [ 12 ]. Likewise, there appears to be a role for possible imbalance between vasodilating and vasoconstricting prostaglandins.…”

Section: Classification Of Hypertensive Disorders Of Pregnancymentioning

confidence: 99%

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A Comprehensive Review of Hypertension in Pregnancy

Mustafa

Ahmed

Gupta

et al. 2012

Journal of Pregnancy

Self Cite

229

203

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Hypertension is the most common medical disorder encountered during pregnancy. Hypertensive disorders are one of the major causes of pregnancy-related maternal deaths in the United States. We will present a comprehensive update of the literature pertinent to hypertension in pregnancy. The paper begins by defining and classifying hypertensive disorders in pregnancy. The normal vascular and renal physiological changes which occur during pregnancy are detailed. We will summarize the intriguing aspects of pathophysiology of preeclampsia, emphasizing on recent advances in this field. The existing diagnostic tools and the tests which have been proposed for screening preeclampsia are comprehensively described. We also highlight the short- and long-term implications of preeclampsia. Finally, we review the current management guidelines, goals of treatment and describe the potential risks and benefits associated with various antihypertensive drug classes. Preeclampsia still remains an enigma, and the present management focuses on monitoring and treatment of its manifestations. We are hopeful that this in depth critique will stimulate the blossoming research in the field and assist practitioners to identify women at risk and more effectively treat affected individuals.

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Section: Classification Of Hypertensive Disorders Of Pregnancymentioning

confidence: 99%

Section: Classification Of Hypertensive Disorders Of Pregnancymentioning

confidence: 99%

A Comprehensive Review of Hypertension in Pregnancy

Mustafa

Ahmed

Gupta

et al. 2012

Journal of Pregnancy

Self Cite

229

203

View full text Add to dashboard Cite

show abstract

“…Last, attempts has been made to produce animal models for preeclampsia, but most are imcomplete compared to the full spectrum of the human disease (14). However, some or most clinical signs can be produced in laboratory animals by uteroplacental hypoperfusion, dietary manipulation, alterations in endothelial function (nitric oxice synthesis inhibition, lowdose endotoxin infusion) and gene manipulation (14,15). Administration of sFlt1 (soluble fms-like tyrosine kinase 1) to pregnant rats induces hypertension, proteinuria, and glomerular endotheliosis, the classic lesion of preeclampsia (16).…”

Section: Introductionmentioning

confidence: 99%

Genetic aspects of preeclampsia

Laivuori

2007

Front Biosci

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Preeclampsia has a familial component suggesting that one or more common alleles may act as susceptibility genes. Some families may have "private" predisposing mutations. The central role of the placenta in the pathogenesis of preeclampsia implies that fetal genes contribute to the disease process. Twin studies support the role of maternal and fetal gene interaction. Candidate gene studies have not yielded consistent results. Genome-wide linkage studies provide powerful means to study disease susceptibility genes, and several loci have been mapped. Parent-of-origin effect of the STOX1 gene has been suggested on chromosome 10q22 locus in the Dutch population. Maternally inherited missense mutations in the STOX1 gene of the fetus have been shown to co-segregate with the maternal preeclamptic phenotype. Up-regulation of placental leptin expression has been found in several studies and might be of importance in the pathogenesis of preeclampsia. DNA microarray is ideal tool for screening gene expression in preeclamptic tissues, but critical attitude is needed when interpreting the results. The placental DNA and mRNA in maternal plasma hold great promise as novel biomarkers for the prediction of preeclampsia. Finding genes prediposing to preeclampsia will enhance our understanding of the disease mechanism, and might allow identification of prognostic and therapeutic subgroups.

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Animal Models

Cited by 2 publications

References 162 publications

A Comprehensive Review of Hypertension in Pregnancy

A Comprehensive Review of Hypertension in Pregnancy

Genetic aspects of preeclampsia

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