Animal Models

Hau, Jann

doi:10.1201/b10837-2

Cited by 11 publications

(20 citation statements)

References 24 publications

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“…For this purpose an updated classifi cation of Hau, developed from his earlier one (Hau, 2003), should guide the researcher towards a fi nal decision. It is recommended to categorize the animal-disease model in one of the following fi ve groups: (1) induced, (2) spontaneous, (3) gene-modifi ed (a: transgenic, b. knock-out, c. chemically induced), (4) negative, (5) orphan.…”

Section: General Guidelinesmentioning

confidence: 99%

Methods and interpretation of performance studies for dental implants

Dard

2012

Biocompatibility and Performance of Medical Devices

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Section: General Guidelinesmentioning

confidence: 99%

Methods and interpretation of performance studies for dental implants

Dard

2012

Biocompatibility and Performance of Medical Devices

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“…Lo que ha permitido alcanzar una mayor comprensión en gran variedad de campos, así como predicciones más acertadas en cuanto a respuestas del organismo ante diversos estímulos, ambientes y tratamientos (Hau, 2003).…”

Section: Modelo Animal De Miedo Y Ansiedadunclassified

“…Es fundamental, para no cometer tales errores, conocer las limitaciones de cada modelo, tales como las diferencias entre especies, la intervención de otros factores no asociados con la condición bajo estudio, la falta de un modelo que nos replique la totalidad de las características presentadas en el ser humano (Hau, 2003;Shanks, Greek & Greek, 2009), además de las dificultades de replicar funciones humanas complejas (Shanks et al, 2009). Ante este panorama, se ha buscado asociar conductas propias de la biología animal, que respondan de una forma similar a la conducta análoga en el ser humano.…”

Section: Modelo Animal De Miedo Y Ansiedadunclassified

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Modelos animales de miedo y ansiedad: descripciones neuro-conductuales

Gallegos

Castillo

2014

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Modelos animales de miedo y ansiedad: descripciones neuro-conductualesResumen. Los modelos animales de miedo y ansiedad se han utilizado para la comprensión de trastornos de ansiedad en humanos, sin embargo no ha sido fácil diferenciar ambos conceptos a nivel fisiológico y conductual. Una forma de modelar estos trastornos es mediante pruebas conductuales de ansiedad (como el laberinto en cruz elevado o la prueba de campo abierto) y de miedo (como el condicionamiento al miedo y la evitación activa). Además, estos modelos permiten estudiar diferentes áreas cerebrales involucradas como la amígdala, el hipocampo y la corteza prefrontal. En general, el miedo y la ansiedad se pueden considerar respuestas adaptativas normales, sin embargo niveles elevados de ambos pueden generar consecuencias perjudiciales para el individuo. Palabras clave. Modelos animales, ansiedad, miedo, comportamiento.Abstract. Animal models of fear and anxiety have been widely used for the comprehension of anxiety disorders in humans, however, it has not been easy to distinguish between both concepts at physiological and behavioral levels. One way to model anxiety disorders is through behavioral tests of anxiety, (such as the elevated plus maze and the open field test), and fear (using the fear conditioning paradigm and active avoidance). Furthermore, animal models are relevant to study the involvement of different brain areas, like the amygdala, hippocampus and prefrontal cortex. In general, fear and anxiety can be considered as normal adaptive responses; however, elevated levels of both might generate detrimental consequences for the individual.

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“…As much as possible, these items must be controlled. 4 • Experimental design and the life situation of the target species must correspond. A model cannot be separated from the experimental design itself.…”

Section: Extrapolation From Animals To Humansmentioning

confidence: 99%

Selection of Biomedical Animal Models

Rand

Sourcebook of Models for Biomedical Research

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Laboratory animals play a crucial role in research discovery and technological advances, and they will continue to take part in improving the lives of people and other animals. It is incumbent upon the researcher to know his subject well in order to provide relevant information to the scientific world. In an effort to assist the biomedical researcher in gaining this knowledge, this chapter provides the following key elements: definition of types of animal models, legislative and legal requirements, criteria for choosing a model, extrapolation validity recommendations, and descriptive features for publication.

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Animal Models

Cited by 11 publications

References 24 publications

Methods and interpretation of performance studies for dental implants

Methods and interpretation of performance studies for dental implants

Modelos animales de miedo y ansiedad: descripciones neuro-conductuales

Selection of Biomedical Animal Models

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