2021
DOI: 10.1177/0023677221990688
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Animal models for cystic fibrosis: a systematic search and mapping review of the literature. Part 2: nongenetic models

Abstract: Various animal models are available to study cystic fibrosis (CF). These models may help to enhance our understanding of the pathology and contribute to the development of new treatments. We systematically searched all publications on CF animal models. Because of the large number of models retrieved, we split this mapping review into two parts. Previously, we presented the genetic CF animal models. In this paper we present the nongenetic CF animal models. While genetic animal models may, in theory, be preferab… Show more

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Cited by 5 publications
(2 citation statements)
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“…Problems employing such CF models include the expense of generation and maintaining such colonies, the development of disease in organs other than the lung that can lead to early death, and the incomplete anatomical identity of defects in mice and humans. To complement such efforts and for simpler solutions for studying Pseudomonas-pulmonary interactions, pulmonary models have been developed that use normal mice (as reviewed in [47][48][49][50][51][52][53][54][55][56]59]). Studies of rats have produced similar results.…”
Section: Discussionmentioning
confidence: 99%
“…Problems employing such CF models include the expense of generation and maintaining such colonies, the development of disease in organs other than the lung that can lead to early death, and the incomplete anatomical identity of defects in mice and humans. To complement such efforts and for simpler solutions for studying Pseudomonas-pulmonary interactions, pulmonary models have been developed that use normal mice (as reviewed in [47][48][49][50][51][52][53][54][55][56]59]). Studies of rats have produced similar results.…”
Section: Discussionmentioning
confidence: 99%
“…Since animals do not have CF naturally, there has to be some manipulation of the animal in order to generate symptoms of the disease and this requires either genetic mutation techniques, used for the genetic models, or non-genetic approaches, including the use of drugs, deliberate infection with pathogens, or grafting human tissues into the animals' lungs. There are more than 220 non-genetic animal models for CF, again the majority of these use mice, but there are also rats, pigs, monkeys, and rabbits (Leenaars et al, 2021).…”
Section: Understanding Cystic Fibrosismentioning
confidence: 99%