Animal models for diabetes: Understanding the pathogenesis and finding new treatments

King, Aileen; Bowe, James

doi:10.1016/j.bcp.2015.08.108

Cited by 131 publications

(140 citation statements)

References 187 publications

(201 reference statements)

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“…Although this model of hyperglycemia and subsequent delayed wound healing does not mimic the long-term chronic, pressure wounds associated with human diabetes, the model lends itself to a study of mechanism and therapeutic response. 30 Body weights were recorded periodically. Blood glucose measurements were taken by using a True Track Smart System glucometer (Home Diagnostics, Ft. Lauderdale, FL).…”

Section: Animals and Induction Of Diabetesmentioning

confidence: 99%

Topical Naltrexone Is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

McLaughlin

Cain

Titunick

et al. 2017

Advances in Wound Care

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Objective: Diabetes affects more than 29 million individuals in the United States, resulting in healthcare costs approaching $245 billion. Approximately 15% of these individuals will develop a chronic, non-healing foot ulcer (diabetic foot ulcer [DFU]) that, if untreated, may lead to amputation. The current treatments for DFU are expensive, have significant side-effects, and often result in non-compliance. A new topical treatment is described that accelerates cutaneous wound repair and is disease modifying by targeting underlying aberrant diabetic pathways. Approach: The efficacy of naltrexone (NTX), an opioid receptor antagonist, and Regranex Ò was compared in preclinical studies using type 1 diabetic rats. Dorsal cutaneous wounds were treated topically with 0.03% NTX, Regranex, or moisturizing cream alone. Wound closure, DNA synthesis, and cytokine production were monitored. Results: Wound closure rates with topical NTX in type 1 diabetic rats were comparable to Regranex. Topical NTX accelerated DNA synthesis, as measured by BrdU incorporation, increased mast cells, and enhanced expression of platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF), a marker for angiogenesis. Regranex had little effect on DNA synthesis, mast cells, and VEGF expression relative to vehicle-treated wounds, and it only temporarily increased PDGF expression. Fibroblast growth factor expression was not altered by either treatment. Innovation: Topical application of 0.03% NTX cream accelerates diabetic wound closure. Conclusion: Blockade of the opioid growth factor (OGF)-OGF receptor (OGFr) axis utilizing 0.03% NTX cream is comparable to standard care in preclinical studies, and it provides a safe, inexpensive, and effective alternative for treatment of diabetic wounds.

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Section: Animals and Induction Of Diabetesmentioning

confidence: 99%

Topical Naltrexone Is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

McLaughlin

Cain

Titunick

et al. 2017

Advances in Wound Care

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“…48 Tip 1 DM β-hücrelerinin yıkımlanmasın-dan dolayı insülin eksikliği ile karakterize otoimmün bir hastalıktır (Tablo 5). 49 Çevresel faktörlerin (viral enfeksiyonlar, toksinler ve psikososyal etmenler) genetik yatkınlığı olan hastalarda önemli rol oynadığı düşünülmek-tedir. 48 Tip 2 DM kısmi insülin eksikliği, sıklıkla periferik İD ve pankreatik β-hücrelerinin yetersizliği sonucu ortaya çıkmaktadır.…”

Section: Di̇abetes Melli̇tusunclassified

“…Kalıtsal unsurların Tip 2 DM gelişiminde büyük bir etkisi olmakla birlikte, obezite ve hareketsiz yaşam tarzı da hastalığın gelişiminde önemli bir rol oynamaktadır. 49 …”

Section: Di̇abetes Melli̇tusunclassified

“…51 Obez olmayan diyabetik [non-obese diabetic (NOD)] fare, BioBreeding diyabet eğilimli [BioBreeding diabetes prone (BB-DP)] sıçan, Komeda diyabet eğilimli (KDP) sıçan, Lew.1AR1 sıçan spontan gelişen Tip 1 DM hayvan modelleridir (Tablo 6). 49 Alternatif olarak Akita faresi otoimmün mekanizmaya bağlı olmayan nedenlerle meydana gelen fonksiyonel insülin eksikliğinde kullanılan bir modeldir. 52 Akita farelerinin insüline karşı duyarlı olması ve endojen beta hücrelerinin yenilenememesi özelliği ile adacık nakli çalışmaları için ideal bir modeldir.…”

Section: Ti̇p 1 Di̇yabetunclassified

“…Her iki cinsiyette genellikle insülitis 4-5 haftalık yaşta başlamaktadır (insanlara göre çok daha erken şekillenmektedir) ve insülitis β-hücre kitlesinin azalması ile de ilişkilidir. 49,53 Ancak bu durum insanlarda şekillenen insülitis tablosundan çok farklıdır. Bu farklılıklar adacıkların etrafını lenfositlerin çevrelemesi ile başlamakta ve adacıklara doğru çok sayıda lökosit infiltrasyonu (çoğunlukla CD4 + ve CD8 + T-hücreleri) ile devam etmektedir.…”

Section: Obez Olmayan Diyabetik Fareunclassified

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Metabolic Syndrome and Diabetic Experimental Animal Models

Çelik¹,

Haliloğlu²

2017

Turkiye Klinikleri J Lab Anim

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Effects of the fenugreek extracts on high‐fat diet‐fed and streptozotocin‐induced type 2 diabetic mice

Wang

et al. 2018

Anim Models and Exp Med

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Background To study the antidiabetic effects and mechanisms of the fenugreek extracts in streptozotocin ( STZ )‐induced type 2 diabetic (T2 DM ) mice fed a high‐fat diet ( HFD ). Methods We established C57 BL /6J mice model of T2 DM using HFD ‐fed and STZ ‐induced method. Then, the mice were administered with two types of fenugreek extracts (E1, flavonoid and E2, stilbene glycoside) for 4 weeks and the effects on fasting blood glucose ( FBG ), weight, superoxide dismutase ( SOD ), catalase ( CAT ), malondialdehyde ( MDA ), and pathological indexes were investigated. Results Administration of fenugreek extracts decreased the FBG level compared with that of the model group. Comparatively, the high‐dose E2 decreased the FBG more significantly than the other treatments did. Both extracts showed an obvious antioxidant effect by increasing serum SOD and CAT activities and decreasing the MDA content. Furthermore, the high‐dose E1 showed a significant difference ( P < .01) compared with the model group in the three investigated indexes. Conclusion Our study demonstrated that both the flavonoid and stilbene glycoside extracts of fenugreek improved the hyperglycemia in the T2 DM mice model. Moreover, the antidiabetic effects of both extracts might be due to their antioxidant activity in vivo.

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Animal models for diabetes: Understanding the pathogenesis and finding new treatments

Cited by 131 publications

References 187 publications

Topical Naltrexone Is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

Topical Naltrexone Is a Safe and Effective Alternative to Standard Treatment of Diabetic Wounds

Metabolic Syndrome and Diabetic Experimental Animal Models

Effects of the fenugreek extracts on high‐fat diet‐fed and streptozotocin‐induced type 2 diabetic mice

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