Animal models for influenza virus transmission studies: a historical perspective

Bouvier, Nicole M.

doi:10.1016/j.coviro.2015.06.002

Cited by 50 publications

(42 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to understand the rapid spreading characteristics of SARS-CoV-2, additional animal models that mimic high human-to-human transmission of SARS-CoV-2 infections are warranted. Given that ferret ACE2 has been shown to contain critical SARS-CoV binding residues (Wan et al, 2020), we performed infection and direct and indirect contact transmission studies using a ferret model previously developed for influenza virus infections (Park et al, 2018;Bouvier, 2015).…”

Section: Discussionmentioning

confidence: 99%

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Kim

et al. 2020

Cell Host & Microbe

904

1,047

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Kim

et al. 2020

Cell Host & Microbe

904

1,047

View full text Add to dashboard Cite

show abstract

“…The first animals that investigators were able to infect with the human influenza virus were ferrets [1] and this model remains in until today [29]. Yet, as convenient experimental models were required, rodents, including mice, hamsters, cotton rats and guinea pigs, became widely used [30].…”

Section: No Current Laboratory Model Has Fully Reproduced All Aspectsmentioning

confidence: 99%

“…The use of animal models in influenza research has been extensively discussed in previous reviews [29,30,33,[87][88][89]. In brief, mice [30], ferrets [35], guinea pigs, swine and non-human primates are commonly used to study influenza.…”

Section: Animal Modelsmentioning

confidence: 99%

Alternative Experimental Models for Studying Influenza Proteins, Host–Virus Interactions and Anti-Influenza Drugs

Chua

Engelberg

et al. 2019

Pharmaceuticals

View full text Add to dashboard Cite

Ninety years after the discovery of the virus causing the influenza disease, this malady remains one of the biggest public health threats to mankind. Currently available drugs and vaccines only partially reduce deaths and hospitalizations. Some of the reasons for this disturbing situation stem from the sophistication of the viral machinery, but another reason is the lack of a complete understanding of the molecular and physiological basis of viral infections and host-pathogen interactions. Even the functions of the influenza proteins, their mechanisms of action and interaction with host proteins have not been fully revealed. These questions have traditionally been studied in mammalian animal models, mainly ferrets and mice (as well as pigs and non-human primates) and in cell lines. Although obviously relevant as models to humans, these experimental systems are very complex and are not conveniently accessible to various genetic, molecular and biochemical approaches. The fact that influenza remains an unsolved problem, in combination with the limitations of the conventional experimental models, motivated increasing attempts to use the power of other models, such as low eukaryotes, including invertebrate, and primary cell cultures. In this review, we summarized the efforts to study influenza in yeast, Drosophila, zebrafish and primary human tissue cultures and the major contributions these studies have made toward a better understanding of the disease. We feel that these models are still under-utilized and we highlight the unique potential each model has for better comprehending virus-host interactions and viral protein function.

show abstract

“…Additionally, ferrets are ideal for IAV in vivo studies, as they exhibit clinical symptoms of infection and can transmit IAV through sneezing [23]. While the ferret model is used for pathogenesis, transmission, and virulence studies, the host response at the molecular level has only resulted in a handful of publications.…”

Section: Host Response Models Of Iav Infectionmentioning

confidence: 99%

Influenza-Omics and the Host Response: Recent Advances and Future Prospects

Powell

Waters

2017

Pathogens

View full text Add to dashboard Cite

Influenza A viruses (IAV) continually evolve and have the capacity to cause global pandemics. Because IAV represents an ongoing threat, identifying novel therapies and host innate immune factors that contribute to IAV pathogenesis is of considerable interest. This review summarizes the relevant literature as it relates to global host responses to influenza infection at both the proteome and transcriptome level. The various-omics infection systems that include but are not limited to ferrets, mice, pigs, and even the controlled infection of humans are reviewed. Discussion focuses on recent advances, remaining challenges, and knowledge gaps as it relates to influenza-omics infection outcomes.

show abstract

Animal models for influenza virus transmission studies: a historical perspective

Cited by 50 publications

References 72 publications

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Alternative Experimental Models for Studying Influenza Proteins, Host–Virus Interactions and Anti-Influenza Drugs

Influenza-Omics and the Host Response: Recent Advances and Future Prospects

Contact Info

Product

Resources

About