Animal Models for Probiotic Interventions Under Gut Inflammatory Conditions

Devi, Priyanka; Nanaji, Yerramsetti; Khanna, Nikita; Yadav, Ashok Kumar; Pawar, Sandip V.

doi:10.1007/978-981-33-6236-9_4

Cited by 2 publications

(5 citation statements)

References 165 publications

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“…These alpha diversity-related changes in gut microbiota following CCI correspond with the earlier research findings ( Nicholson et al, 2019 ; Davis et al, 2021 , 2022 ; Du et al, 2021 ; Frankot et al, 2023 ). The bidirectional crosstalk of the brain and gut microbiota has also been evident in the management of brain injuries such as stroke, spinal cord injuries, and TBI ( Singh et al, 2016 ; Akhoundzadeh et al, 2018 ; Sun et al, 2018 ; Ma et al, 2019 ; Devi et al, 2021 ; Frankot et al, 2023 ). Thus, as suggested in earlier studies ( Benakis et al, 2016 ; Ma et al, 2019 ), rebuilding gut microflora biodiversity may be essential for recovery from brain injury.…”

Section: Discussionmentioning

confidence: 99%

“…These findings provide promising avenues for better therapeutic strategies in treating neurological illnesses ( Messaoudi et al, 2011a , b ; Zakostelska et al, 2011 ). As probiotics impose a positive impact on brain functions, they also possess a role in influencing the diversity of the gut microbiota, which is crucial for overall wellbeing ( Bienenstock et al, 2015 ; Sirisinha, 2016 ; Akhoundzadeh et al, 2018 ; Ma et al, 2019 ; Devi et al, 2021 ; Savigamin et al, 2022 ). These preliminary results indicate that the sex-specific restoration of gut microbiota may reverse the CCI-generated neurological complications.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, other TBI studies also reported changes in Lactobacillus , Romboutsia, and Turicibacter microbial genera following the injury ( Kang et al, 2019 ; Koopman et al, 2019 ; Li et al, 2019 ; Du et al, 2021 ). Furthermore, probiotic treatment has shown potential benefits in animal models of spinal injuries, TBI, and stroke ( Akhoundzadeh et al, 2018 ; Ma et al, 2019 ; Devi et al, 2021 ; Savigamin et al, 2022 ). In clinical settings, supplementation of Lactobacillus -rich probiotics showed improvement in TBI patients by modifying gut dysfunction ( Tan et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

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Fecal microbiota transplantation unveils sex-specific differences in a controlled cortical impact injury mouse model

Pasam,

Dandekar

2024

Front. Microbiol.

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IntroductionContusion type of traumatic brain injury (TBI) is a major cause of locomotor disability and mortality worldwide. While post-TBI deleterious consequences are influenced by gender and gut dysbiosis, the sex-specific importance of commensal gut microbiota is underexplored after TBI. In this study, we investigated the impact of controlled cortical impact (CCI) injury on gut microbiota signature in a sex-specific manner in mice.MethodsWe depleted the gut microflora of male and female C57BL/6 mice using antibiotic treatment. Thereafter, male mice were colonized by the gut microbiota of female mice and vice versa, employing the fecal microbiota transplantation (FMT) method. CCI surgery was executed using a stereotaxic impactor (Impact One™). For the 16S rRNA gene amplicon study, fecal boli of mice were collected at 3 days post-CCI (dpi).Results and discussionCCI-operated male and female mice exhibited a significant alteration in the genera of Akkermansia, Alistipes, Bacteroides, Clostridium, Lactobacillus, Prevotella, and Ruminococcus. At the species level, less abundance of Lactobacillus helveticus and Lactobacillus hamsteri was observed in female mice, implicating the importance of sex-specific bacteriotherapy in CCI-induced neurological deficits. FMT from female donor mice to male mice displayed an increase in genera of Alistipes, Lactobacillus, and Ruminococcus and species of Bacteroides acidifaciens and Ruminococcus gnavus. Female FMT-recipient mice from male donors showed an upsurge in the genus Lactobacillus and species of Lactobacillus helveticus, Lactobacillus hamsteri, and Prevotella copri. These results suggest that the post-CCI neurological complications may be influenced by the differential gut microbiota perturbation in male and female mice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fecal microbiota transplantation unveils sex-specific differences in a controlled cortical impact injury mouse model

Pasam,

Dandekar

2024

Front. Microbiol.

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“…Interestingly, the usage of a mixture of probiotics has been found to reduce crying by infants with colic during breastfeeding ( Baldassarre et al., 2018 ), and probiotics appear to significantly impact the composition of the neonatal microbiota. It has been suggested that probiotics such as Lactobacillus can interact directly with the host via pattern recognition receptors (PRR), for which the peptidoglycan in the wall of gram-positive bacteria and lipopolysaccharide of gram-negative bacteria serve as ligands ( Devi et al., 2021 ). The direct interaction involves the binding of probiotic bacteria to these receptors on the host’s dendritic and intestinal epithelial cells, thereby preventing cytokine-induced apoptosis and production of defensins and mucus ( Devi et al., 2021 ).…”

Section: The Effect Of Probiotics On Microbiome During Pregnancymentioning

confidence: 99%

“…In addition, probiotics compete with pathogenic species for adhesion to the surface of intestinal epithelial cells. Adhesion molecules such as a mucus-binding protein on the surface of probiotics facilitate their interaction with host dendritic cells, thus enhancing the phagocytic capacity of these cells ( Devi et al., 2021 ).…”

Section: The Effect Of Probiotics On Microbiome During Pregnancymentioning

confidence: 99%

Physiological Changes and Interactions Between Microbiome and the Host During Pregnancy

Zakaria

Al-Rumaihi

Al-Absi

et al. 2022

Front. Cell. Infect. Microbiol.

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In recent years, it has become clear that microbiome play a variety of essential roles in human metabolism, immunity, and overall health and that the composition of these microbiome is influenced by our environment, diet, weight, hormones, and other factors. Indeed, numerous physiological and pathological conditions, including obesity and metabolic syndrome, are associated with changes in our microbiome, referred to as dysbiosis. As a result, it is not surprising that such changes occur during pregnancy, which includes substantial weight gain and significant changes in metabolism and immune defenses. The present review relates physiological changes during pregnancy to alterations in the microbial composition at various sites, including the gut, oral cavity, and vagina. Pregnancy has been linked to such microbial changes, and we believe that, in contrast to certain disease states, these microbial changes are vital for a healthy pregnancy, probably through their influence on the mother’s immunological, endocrinological, and metabolic status.

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Animal Models for Probiotic Interventions Under Gut Inflammatory Conditions

Cited by 2 publications

References 165 publications

Fecal microbiota transplantation unveils sex-specific differences in a controlled cortical impact injury mouse model

Fecal microbiota transplantation unveils sex-specific differences in a controlled cortical impact injury mouse model

Physiological Changes and Interactions Between Microbiome and the Host During Pregnancy

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