Animal Models for Treating Spinal Cord Injury Using Biomaterials-Based Tissue Engineering Strategies

Li, Jiao Jiao; Liu, Haifeng; Zhu, Yuanyuan; Yan, Lei; Liu, Ruxing; Wang, Guishan; Wang, Bin; Zhao, Bin

doi:10.1089/ten.teb.2020.0267

Cited by 19 publications

(14 citation statements)

References 119 publications

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“…As a matter of fact, it is bolstered that electrical stimuli promote nerve regeneration and guide sprouting phenomena [ 100 , 101 ]. Nanomaterials play another critical aspect [ 102 ]. For example, nanocarriers can be used to deliver the drug directly to the site of the lesion and thus avoiding the need for systemic administration with all the advantages that this entails: less toxicity, less expenditure of resources, longer-lasting release.…”

Section: Discussionmentioning

confidence: 99%

Stem Cell Strategies in Promoting Neuronal Regeneration after Spinal Cord Injury: A Systematic Review

Bonosi

Silven

Biancardino

et al. 2022

IJMS

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Spinal cord injury (SCI) is a devastating condition with a significant medical and socioeconomic impact. To date, no effective treatment is available that can enable neuronal regeneration and recovery of function at the damaged level. This is thought to be due to scar formation, axonal degeneration and a strong inflammatory response inducing a loss of neurons followed by a cascade of events that leads to further spinal cord damage. Many experimental studies demonstrate the therapeutic effect of stem cells in SCI due to their ability to differentiate into neuronal cells and release neurotrophic factors. Therefore, it appears to be a valid strategy to use in the field of regenerative medicine. This review aims to provide an up-to-date summary of the current research status, challenges, and future directions for stem cell therapy in SCI models, providing an overview of this constantly evolving and promising field.

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Section: Discussionmentioning

confidence: 99%

Stem Cell Strategies in Promoting Neuronal Regeneration after Spinal Cord Injury: A Systematic Review

Bonosi

Silven

Biancardino

et al. 2022

IJMS

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“…Although the pathological mechanism of SCI is similar across different species, the rate of illness evolution varies, such as between mice and humans. In rodents, secondary injury can be divided into an acute stage (<24 h), a subacute stage (from 24 h to 7 days) and a chronic stage (>7 days) [ 8 ]. In humans, the transition between the acute phase and subacute phase usually occurs within a few hours to 48 h after injury, and the change from acute to chronic phase is thought to happen at 6 months [ 5 ].…”

Section: Reviewmentioning

confidence: 99%

Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications

et al. 2023

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Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete loss of motor and sensory function. Massive neurons are damaged after the initial mechanical insult. Secondary injuries, which are triggered by immunological and inflammatory responses, also result in neuronal loss and axon retraction. This results in defects in the neural circuit and a deficiency in the processing of information. Although inflammatory responses are necessary for spinal cord recovery, conflicting evidence of their contributions to specific biological processes have made it difficult to define the specific role of inflammation in SCI. This review summarizes our understanding of the complex role of inflammation in neural circuit events following SCI, such as cell death, axon regeneration and neural remodeling. We also review the drugs that regulate immune responses and inflammation in the treatment of SCI and discuss the roles of these drugs in the modulation of neural circuits. Finally, we provide evidence about the critical role of inflammation in facilitating spinal cord neural circuit regeneration in zebrafish, an animal model with robust regenerative capacity, to provide insights into the regeneration of the mammalian central nervous system.

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“…The satisfactory treatment of this condition still remains a challenging point in the management of SCI. Stem-cell therapy and tissue engineering strategies played emerging roles in the management of SCI during the last decades [ 67 ]. Indeed, recent evidence from pre-clinical trials for SCI repair studied the implantation effects of a collagen scaffold made from bovine aponeurosis (NeuroRegen scaffolds) together with autologous human bone-marrow mononuclear cells (BMMCs) or allogeneic mesenchymal stem cells (MSCs) in animal models [ 67 ].…”

Section: Management Of Ejaculatory Disorders and Infertility In Scimentioning

confidence: 99%

“…Stem-cell therapy and tissue engineering strategies played emerging roles in the management of SCI during the last decades [ 67 ]. Indeed, recent evidence from pre-clinical trials for SCI repair studied the implantation effects of a collagen scaffold made from bovine aponeurosis (NeuroRegen scaffolds) together with autologous human bone-marrow mononuclear cells (BMMCs) or allogeneic mesenchymal stem cells (MSCs) in animal models [ 67 ]. This system could be used to recover or improve sensory and autonomic nervous functions such as defecation sensation, physiological erections, sweating, and superficial or deep sensations in some SCI patients [ 67 ].…”

Section: Management Of Ejaculatory Disorders and Infertility In Scimentioning

confidence: 99%

Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives

Bello

Creta

Napolitano

et al. 2022

JPM

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Spinal cord injury (SCI) is a relevant medical and social problem. According to the World Health Organization, the commonly estimated worldwide annual incidence of SCI is 40 to 80 cases per million population. After the SCI experience, most men present with sexual dysfunction (erectile dysfunction (ED) and ejaculatory dysfunction), fertility problems (such as impaired spermatogenesis, abnormalities in sperm viability, motility, and morphology), and systemic disorders such as genitourinary infection and endocrine imbalances. The best options available for managing the ejaculatory disorders in patients suffering from SCI are penile vibratory stimulation (PVS) and electroejaculation (EEJ). Furthermore, the treatment of ED in SCI patients consists of medical therapies including phosphodiesterase 5 inhibitors (PDE5i), intracavernosal injections (ICI), vacuum erection devices (VEDs), and surgical as penile prosthesis (PP). This review provides a snapshot of the current evidence for the mechanisms of sexual dysfunction and infertility in SCI patients, discusses the best management strategies for these conditions, and offers our perspective on the direction of future research.

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Animal Models for Treating Spinal Cord Injury Using Biomaterials-Based Tissue Engineering Strategies

Cited by 19 publications

References 119 publications

Stem Cell Strategies in Promoting Neuronal Regeneration after Spinal Cord Injury: A Systematic Review

Stem Cell Strategies in Promoting Neuronal Regeneration after Spinal Cord Injury: A Systematic Review

Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications

Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives

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