Animal models in Alzheimer's disease: Biological plausibility and mood disorders

Rangel, Carlos Castillo; Marín-Márquez, Gerardo; Díaz-Chiguer, Dylan L.; Zarate-Calderon, Cristofer; Viveros-Martinez, I.; Caycho-Salazar, F.D.M.D.J.; Torres-Pasillas, J.G.; Hernández-Contreras, Karla Aketzalli; Vega-Quesada, L.A.; Cano-Ortega, Y.; García-Hernández, L.; Vásquez-Celaya, L.

doi:10.1016/j.neurop.2023.100110

Cited by 4 publications

(2 citation statements)

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“…Finally, we should not forget that autonomic dysfunction in control of inflammation and immunity [33,[70][71][72], endocrine system [48], circadian rhythms [39,[73][74][75][76][77], tissue regeneration [78][79][80], including ANS itself [81] also contributes to chronic pain development and its chronicity.…”

Section: Pathophysiologymentioning

confidence: 99%

“…AD is a neurodegenerative condition showing a progressive deterioration of higher brain functions, mainly memory, and is considered one of the most common dementias [79]. The striking tissue features are the presence of extracellular accumulations of the amyloid beta (Aβ) peptide, or amyloid plaques, and neurofibrillary tangles [80].…”

Section: Alzheimer's Disease (Ad)mentioning

confidence: 99%

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Topics in Autonomic Nervous System

2023

Physiology

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Section: Pathophysiologymentioning

confidence: 99%

Section: Alzheimer's Disease (Ad)mentioning

confidence: 99%

Topics in Autonomic Nervous System

2023

Physiology

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In Vivo Assays for Amyloid-Related Diseases

Espargaró,

Álvarez-Berbel,

Busquets

et al. 2024

Annual Review of Analytical Chemistry

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Amyloid-related diseases, such as Alzheimer's and Parkinson's disease, are devastating conditions caused by the accumulation of abnormal protein aggregates known as amyloid fibrils. While assays involving animal models are essential for understanding the pathogenesis and developing therapies, a wide array of standard analytical techniques exists to enhance our understanding of these disorders. These techniques provide valuable information on the formation and propagation of amyloid fibrils, as well as the pharmacokinetics and pharmacodynamics of candidate drugs. Despite ethical concerns surrounding animal use, animal models remain vital tools in the search for treatments. Regardless of the specific animal model chosen, the analytical methods used are usually standardized. Therefore, the main objective of this review is to categorize and outline the primary analytical methods used in in vivo assays for amyloid-related diseases, highlighting their critical role in furthering our understanding of these disorders and developing effective therapies.

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Zebrafish Experimental Animal Models for AD: A Comprehensive Review

Sande,

Godad,

Doshi

2024

CRCEP

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AD disease (AD) is a multifaceted and intricate neurodegenerative disorder characterized by intracellular neurofibrillary tangle (NFT) formation and the excessive production and deposition of Aβ senile plaques. While transgenic AD models have been found instrumental in unravelling AD pathogenesis, they involve cost and time constraints during the preclinical phase. Zebrafish, owing to their simplicity, well-defined behavioural patterns, and relevance to neurodegenerative research, have emerged as a promising complementary model. Zebrafish possess glutaminergic and cholinergic pathways implicated in learning and memory, actively contributing to our understanding of neural transmission processes. This review sheds light on the molecular mechanisms by which various neurotoxic agents, including okadaic acid (OKA), cigarette smoke extract, metals, and transgenic zebrafish models with genetic similarities to AD patients, induce cognitive impairments and neuronal degeneration in mammalian systems. These insights may facilitate the identification of effective neurotoxic agents for replicating AD pathogenesis in the zebrafish brain. In this comprehensive review, the pivotal role of zebrafish models in advancing our comprehension of AD is emphasized. These models hold immense potential for shaping future research directions and clinical interventions, ultimately contributing to the development of novel AD therapies.

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Animal models in Alzheimer's disease: Biological plausibility and mood disorders

Cited by 4 publications

References 55 publications

Topics in Autonomic Nervous System

Topics in Autonomic Nervous System

In Vivo Assays for Amyloid-Related Diseases

Zebrafish Experimental Animal Models for AD: A Comprehensive Review

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