Animal models in cardiovascular research

Duelsner, André; Persson, Anja Bondke

doi:10.1111/apha.12074

Cited by 4 publications

(4 citation statements)

References 37 publications

(53 reference statements)

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“…Adaptation to hypoxia can be simulated by pharmacological inhibition of PHD, a potentially useful tool in preventing organ damage. Although there is a concern regarding the safety of this treatment option, animal studies, conducted in a clinically relevant fashion (Douelsner & Bondke Persson ), clearly indicate the potential effectiveness in the prevention of organ damage in a host of clinical conditions. Advanced clinical trials are under way in the set‐up of anaemia of chronic disease, and it is conceivable that if such agents are approved for treating anaemia, clinical trials in other scenarios requiring organ salvage will rapidly follow.…”

Section: Discussionmentioning

confidence: 99%

Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

et al. 2015

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Transient ischaemia leads to tolerance to subsequent protracted ischaemia. This 'ischaemia pre-conditioning' results from the induction of numerous protective genes, involved in cell metabolism, proliferation and survival, in antioxidant capacity, angiogenesis, vascular tone and erythropoiesis. Hypoxia-inducible factors (HIF) play a pivotal role in this transcriptional adaptive response. HIF prolyl hydroxylases (PHDs), serving as oxygen sensors, control HIFα degradation. HIF-mediated ischaemic pre-conditioning can be achieved with the administration of PHD inhibitors, with the attenuation of organ injury under various hypoxic and toxic insults. Clinical trials are currently under way, evaluating PHD inhibitors as inducers of erythropoietin. Once their safety is established, their potential use might be further tested in clinical trials in various forms of acute ischaemic and toxic organ damage. Repeated transient limb ischaemia was also found to attenuate ischaemic injury in remote organs. This 'remote ischaemic pre-conditioning' phenomenon (RIP) has been extensively studied recently in small clinical trials, preceding, or in parallel with an abrupt insult, such as myocardial infarction, cardiac surgery or radiocontrast administration. Initial results are promising, suggesting organ protection. Large-scale multi-centre studies are currently under way, evaluating the protective potential of RIP in cardiac surgery, in the management of myocardial infarction and in organ transplantation. The mechanisms of organ protection provided by RIP are poorly understood, but HIF seemingly play a role as well. Thus, Inhibition of HIF degradation with PHD inhibitors, as well as RIP (in part through HIF), might develop into novel clinical interventions in organ protection in the near future.

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Section: Discussionmentioning

confidence: 99%

Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

et al. 2015

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“…To model acute MI in mice one has to revert to surgical models, such as (transient) ligation of the left anterior descending coronary artery (LAD) or the ex vivo Langerdorf perfusion model (Duelsner and Bondke Persson, 2013). Mouse models of acute stress include single sessions of restraint, forced swim, shaking, electric foot shock or exposure to an (aggressive) intruder (Sutanto and de Kloet, 1994).…”

Section: Effect Of Acute Stress On Experimental Cardiovascular Diseasesmentioning

confidence: 99%

Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies

Lagraauw

Kuiper

Bot

2015

Brain, Behavior, and Immunity

210

131

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“…To study atherosclerosis, some animals' models have been used. Rats are among the most favourable animal model because it is low cost, easy to handling and housing, and well-establish genomic data [13]. Although these animal models have important roles in understanding the atherosclerosis lesion formation, there are some limitations of using these animal [14].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, rats also do not have cholesteryl ester transfer protein (CETP) which make them more unsusceptible for atherosclerosis [15]. Several transgenic rats have been developed to study atherosclerosis, such as the CETP transgenic rats [13,15]. However, the transgenic animals are highly cost and not widely available.…”

Section: Introductionmentioning

confidence: 99%

Prolonged-heated High-Fat Diet Increase the Serum LDL Cholesterol Level and Induce the Early Atherosclerotic Plaque Development in Wistar Rats

Yurina¹,

Yunita²,

Raras³

et al. 2019

JTLS

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Rats are one of the most widely used animal models in health research. However, since rats are relatively resistant to atherosclerosis, the transgenic rats often used to study atherosclerosis in rats. Our study suggests a prolonged-heated lipid to induce atherosclerosis in rats, therefore provide a more low-cost option to study atherosclerosis in rats. Aims of this study is to compare the effect of heated highfat diet (HFD) to the LDL and HDL cholesterol level and foam cell formation in the Wistar rat animal model. Rats were divided into three groups, control group was given with the normal diet, and the other two treated groups received oxidized HFD (heated HFD) and HFD, respectively. The heated HFD contain lard that was previously heated at 190°C for 24 h. Diet was given for 8 weeks. The serum LDL and HDL cholesterol level were measured before and 4 th and 8 th weeks after treatment with help of colorimetric measurement. The aorta analyzed for the foam cell formation after HE staining using the light microscope. The prolonged-heated HFD significantly increased the LDL cholesterol from the 4 th week of the treatment (p = 0.023). The rats aortic from HFD and heated HFD treated groups showed a mononuclear cells infiltration and the early foam cell formation. The heating process of the lipid caused lipid oxidation which significantly increased the LDL cholesterol level of the animal model and foam cells formation. This study suggests that Wistar rats with heated HFD could demonstrated early atherosclerosis plaque development.

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Animal models in cardiovascular research

Cited by 4 publications

References 37 publications

Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

Adaptive response to hypoxia and remote ischaemia pre‐conditioning: a new hypoxia‐inducible factors era in clinical medicine

Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies

Prolonged-heated High-Fat Diet Increase the Serum LDL Cholesterol Level and Induce the Early Atherosclerotic Plaque Development in Wistar Rats

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