Animal Models in Dental Research

Nokhbatolfoghahaei, Hanieh; Paknejad, Zahrasadat; Bohlouli, Mahboubeh; Rad, Maryam Rezai; Khojasteh, Arash

doi:10.1007/978-3-030-21583-5_18

Cited by 4 publications

(2 citation statements)

References 368 publications

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“…Additionally, the hydration reaction of the tricalcium silicate phase produced CSH and calcium hydroxide 19,20) . Dogs were selected as animal models due to their similar phylogeny, anatomy, and physiology to humans, as well as acceptable pulp-dentin response and similar healing process 21) . Moreover, dogs have an adequate number of teeth allowing the comparison of multiple materials on the same dog and minimizing the number of sacrificed animals following ethical considerations 22) .…”

Section: Discussionmentioning

confidence: 99%

Regenerative potential of a novel aloe vera modified tricalcium silicate cement as a pulp capping material: An animal study

SEIF,

ELBANNA,

ABU-SEIDA

et al. 2023

Dent. Mater. J.

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This study compared the histologic response of a pulp capping material Matreva MTA modified with different concentrations of aloe vera (AV) solutions to Biodentine cement. Ninety dogs' teeth were included and categorized according to the capping material into five groups (18 teeth each); Group I (Biodentine), group II (Matreva MTA), group III (Matreva MTA 10% AV), group IV (Matreva MTA 20% AV) and group V (Matreva MTA 30% AV). The histopathological findings were recorded at 2, 4, and 8 weeks. Matreva MTA and Biodentine groups showed the highest inflammatory cell count compared to the AV-modified Matreva MTA groups at 2-and 4-week intervals (p>0.05). Moreover, the AV-modified Matreva MTA and Biodentine groups showed higher dentin bridge thickness compared to unmodified Matreva MTA at different follow-up periods (p<0.05). AV can significantly enhance the in vivo bioactivity of Matreva MTA, inducing mild inflammation and good dentine bridge formation comparable to Biodentine.

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Section: Discussionmentioning

confidence: 99%

Regenerative potential of a novel aloe vera modified tricalcium silicate cement as a pulp capping material: An animal study

SEIF,

ELBANNA,

ABU-SEIDA

et al. 2023

Dent. Mater. J.

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“…The use of animal species is a common practice in dental research, with a predominance of rodents, mainly due to physiological characteristics that may mimic human behavior. Because of the often superiority to in vitro research, a high-quality designed animal model supports future clinical trials in humans ( Bernardino et al, 2014 , Nokhbatolfoghahaei et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Accuracy of radiographic pixel linear analysis in detecting bone loss in periodontal disease: Study in diabetic rats

Bueno

Sumida

Duarte

et al. 2021

The Saudi Dental Journal

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Introduction Periodontitis, a complex infectious disease that may lead to irreversible loss of periodontium, is considered a predisposing agent for developing insulin resistance due to the release of inflammatory mediators, showing a bilateral relationship with diabetes mellitus. The investigation of periodontal disease requires a clinical approach and complete intraoral radiographs, even with increasing concerns about radiation exposure. Thus, this study assesses pixel linear analysis accuracy using digital radiography via Digora® in detecting alveolar bone destruction in diabetic rats with periodontal disease. Methodology 40 rats were divided into groups (n = 10): control (C), rats with periodontal disease (PD), experimental diabetic rats (ED), experimental diabetic rats with periodontal disease (ED-PD). Diabetes was induced by streptozotocin and periodontal disease by periodontal ligature. After 30 days, maxillae bone destruction was obtained by linear analysis of vertical bone loss using digital radiography and then assessed by micro-CT and histology. Data were analyzed by ANOVA and Tukey’s test (p < 0.05). Results Radiographic, micro-CT and histological analysis presented accurate and similar results. PD and ED-PD groups showed higher bone destruction than C and ED groups (p < 0.05). Moreover, the ED-PD group had higher bone loss than the PD group (p < 0.05). Conclusion The pixel linear analysis via digital radiography was an accurate, low-cost alternative in detecting alveolar bone loss in this rat model. Micro-CT and histological analysis may also be used to obtain linear measures to assess and compare periodontal bone destruction in diabetic rats.

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Deneysel Hayvan Çalışmalarında Pulpitis Modelleri: Geleneksel Derleme

Pirimoglu,

Keskin,

Aksoy

2024

Türk Diş Hekimliği Araştırma Dergisi

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Hayvan deneyleri, hayvanların bilimsel çalışmalarda etik ilkeler doğrultusunda kontrollü olarak kullanılmasıdır. Deneysel in vivo araştırmalarda denek kullanmak bir zorunluluktur; bu yüzden deney hayvanları insan deneklere bir alternatif olmuştur. In vitro deneyler ile elde edilen verilerin klinik uygulamalardan uzak olması sebebiyle sınırlı bilgi sağlarlar. İyi tasarlanmış bir hayvan deneyi, insanlarda gelecekteki klinik deneyler için temel bilgiler sağlar. Hayvan deneyleri, hastalıklar hakkında bilgi edinilmesinde, yeni bir ilaç veya cerrahi tekniğin test edilmesinde bilime önemli katkılar sağlamıştır. Diş hekimliği alanında, özelikle de endodonti alanında da birçok çalışmada hayvan modelleri kullanılmıştır. Bu çalışmaların yapılabilmesi için öncellikli olarak uygun bir hayvan modeli ve etik ilkeler ile elde edilecek sonuçların uyarlanabilir olması gerekir. Dental anomalilerin, morfolojinin, hastalık süreci ve iyileşmesinin tüm yönlerini gösteren tek bir hayvan modeli olmadığı için, genellikle hastalık ve tedavi mekanizmaları hakkında bilgi sağlayan spesifik modeller kullanılmaktadır. Diş hekimliği araştırmalarında, maymun, köpek, tavşan, koyun, domuz, gelincik, sıçan ve fareler hayvan modelleri için kullanılmaktadır. Çalışmanın amacı, hipotezi, uygulanacak analiz teknikleri ve elde edilecek sonuçların insan için uyarlanabileceği hayvan modeli seçilmelidir. Çalışmada kullanılan deney hayvanlarının refahı, yasa ve yönetmeliklerine uygun olmalıdır ve hayvanların gereksiz acı ve sıkıntıya maruz kalmaması sağlanmalıdır. Bu derlemede, endodonti alanında hayvan modeli araştırması planlanırken hayvan modelinin seçimi, çalışmanın işleyişi ve etik kuralların uygulanması ele alınmıştır.

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Animal Models in Dental Research

Cited by 4 publications

References 368 publications

Regenerative potential of a novel aloe vera modified tricalcium silicate cement as a pulp capping material: An animal study

Regenerative potential of a novel aloe vera modified tricalcium silicate cement as a pulp capping material: An animal study

Accuracy of radiographic pixel linear analysis in detecting bone loss in periodontal disease: Study in diabetic rats

Deneysel Hayvan Çalışmalarında Pulpitis Modelleri: Geleneksel Derleme

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