Animal Models in Translational Pain Research

Abstract

Animal models play a crucial role in translational pain research. They provide a means to understand the underlying mechanisms of pain, test potential therapeutic approaches, and simulate various pain conditions. This chapter explores the significance and application of different animal models in this field. Rodent models, such as mice and rats, are commonly used due to their genetic manipulability and ease of handling. For instance, neuropathic pain models can be induced by nerve injury to study the changes in neuronal circuitry and molecular pathways. Moreover, primate models offer closer similarities to human physiology and behavior, allowing for more accurate assessment of pain perception and responses. However, each model has its limitations, and careful consideration must be given to the selection and interpretation of results. Future research should focus on developing more refined and clinically relevant animal models to accelerate the translation of findings from bench to bedside and improve pain management strategies for patients.