Animal Models of Allergic Rhinitis

Szelenyi, Istvan; Marx, Degenhard; Jahn, W

doi:10.1055/s-0031-1300330

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Mucus hypersecretion with airway obstruction during the secondary phase is accompanied by a progression in mucosal swelling, tissue infiltration of eosinophils and neutrophils, and the synthesis and release of prostaglandins, interleukins, and reactive oxygen species (ROS). In the allergic guinea pig, enumerating the frequency of nasal rubbing and sneezes is a subjective but useful measure, especially for testing the early phase mechanisms and therapies involving histamine-and leukotriene-dependent pathways (Al Suleimani et al 2006;Szelenyi et al 2000). For example observers will count between 3-6 sneezes and 6-10 rubbings per minute after acute exposure to allergen (Al Suleimani et al 2008;Tsunematsu et al 2007).…”

Section: Animal Models Of Allergic Rhinitismentioning

confidence: 99%

From Mouse to Man: Translational Value of Animal Models of Allergic Rhinitis

Wagner¹,

Harkema²

2012

Allergic Rhinitis

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Section: Animal Models Of Allergic Rhinitismentioning

confidence: 99%

From Mouse to Man: Translational Value of Animal Models of Allergic Rhinitis

Wagner¹,

Harkema²

2012

Allergic Rhinitis

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“…Although the nose is easily accessible for study and considerable amount of information can be gained from human studies, there is no doubt that we also need animal rhinitis models. We have developed a rhinitis model in anesthetized domestic pigs for studying drugs on symptoms of experimental rhinitis [19,20]. Increased mucus secretion can been observed in different models of allergic asthma (reviewed in [21]).…”

Section: Qualitative and Quantitative Changes In Mucus Productionmentioning

confidence: 99%

Animal Models of Chronic Obstructive Pulmonary Disease

Szelenyi¹,

Marx²

2011

Arzneimittelforschung

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Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Despite the high prevalence and enormous cost to healthcare and society, COPD has received scant attention in comparison to other respiratory conditions such as asthma and lung cancer. It is often thought of as a self-inflicted disease. But not all people who smoke develop COPD and not all patients with COPD are smokers. The causes of COPD are different. Its pathogenesis is complex. There are very few effective treatments. Therefore, there is an urgent need to improve present therapy by drugs with new modes of actions. In contrast to many human diseases, chronic bronchitis and emphysema occur seldom in the animal world. Therefore, we have to mimic some characteristic features of these diseases in animals. For this reason, a wide variety of animal models have been developed and are employed in the search for new chemical entities for the treatment of COPD. In the present paper, the experimental models of COPD are critically reviewed.

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Rodent models of allergic rhinitis: Relevance to human pathophysiology

Wagner

Harkema²

2007

Curr Allergy Asthma Rep

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Rodent models of allergic airways disease employ a wide range of test allergens, sensitization and provocation protocols, animal strains, and experimental endpoints. Studies of experimental asthma, especially the use of murine models, have contributed significantly to the understanding of the genetics and immune-mediated pathophysiology of pulmonary airways during allergy. By comparison, rodent models of allergic rhinitis are less well developed. Recent interest in the potential mechanistic links between asthma and allergic rhinitis has increased the need for relevant animal studies directed at upper airways responses. Specifically, the nature of nasal airway remodeling in response to chronic activation of allergic pathways and its relationship to airway occlusion is not well described. This cursory review discusses current approaches to assessing nasal obstruction in rodent models, and how the histopathologic analysis might be improved to facilitate understanding of the pathogenesis of allergic rhinitis in humans.

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Animal Models of Allergic Rhinitis

Cited by 5 publications

References 24 publications

From Mouse to Man: Translational Value of Animal Models of Allergic Rhinitis

From Mouse to Man: Translational Value of Animal Models of Allergic Rhinitis

Animal Models of Chronic Obstructive Pulmonary Disease

Rodent models of allergic rhinitis: Relevance to human pathophysiology

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