2014
DOI: 10.1007/s13258-014-0188-7
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Animal models of amyotrophic lateral sclerosis and Huntington’s disease

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Cited by 4 publications
(2 citation statements)
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“…Nevertheless, the generation in 1993 of the first transgenic SOD1 G93A mouse model which closely mimics human fALS pathology was paradigmatic as it has allowed the scientific community to investigate ALS disease mechanisms in preclinical species for the first time ( Gurney et al, 1994 ). To this day, rodent SOD1 mutants remain as the most widely employed ALS models to study both the cellular and molecular disease mechanisms and to test the potential efficacy of novel therapeutic compounds ( Islam et al, 2014 ).…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, the generation in 1993 of the first transgenic SOD1 G93A mouse model which closely mimics human fALS pathology was paradigmatic as it has allowed the scientific community to investigate ALS disease mechanisms in preclinical species for the first time ( Gurney et al, 1994 ). To this day, rodent SOD1 mutants remain as the most widely employed ALS models to study both the cellular and molecular disease mechanisms and to test the potential efficacy of novel therapeutic compounds ( Islam et al, 2014 ).…”
Section: Introductionmentioning
confidence: 99%
“…This study adopted zebrafish embryogenesis as an in vivo assay for the detection of biological toxicity in samples of pink water. The zebrafish has numerous advantages for investigations of biotoxicity [28,29,30] and for modelling devastating human diseases [31,32]. Zebrafish embryos are small, can be obtained in large quantities, and develop externally, making them suitable for high-throughput assays.…”
Section: Discussionmentioning
confidence: 99%