Animal models of chemotherapy‐induced peripheral neuropathy for hematological malignancies: A review

Abstract

Chemotherapy is one of the main treatments for hematologic malignancies.However, chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common long-term toxic reactions in chemotherapy, and the occurrence of CIPN affects patients' quality of life and can cause interruption of chemotherapy in severe cases, thus reducing the efficacy of chemotherapy. We currently summarize the existing CIPN animal models, including the characteristics of several common animal models such as bortezomibinduced peripheral neuropathy, vincristine-induced peripheral neuropathy, and oxaliplatin-induced peripheral neuropathy. It was found that CIPN may lead to behavioral, histopathological, and neurophysiological changes inducing peripheral neuropathy. However, the mechanism of CIPN has not been fully elucidated, especially the prevention and treatment protocols need to be improved. Therefore, this review article summarizes the progress of research on CIPN animal models and the possible mechanisms and treatment of CIPN.

Exploring the Potential Pharmacological Effect of Thymoquinone in Ameliorating the Acquisition and Expression of Vincristine Induced Neuropathic Pain in Mice

“…(2,43). VCR stimulates NF-κB signalling, which causes inflammatory and immune responses that might cause cellular damage and the release of cytokines and chemokines (25). Nitric oxide, cyclo-oxygenase-2 (COX-2), and inflammatory cytokines including TNF-α, and IL-1β are all stimulated by the NF-κB axis.…”

“…On experiment day, group 1:normal saline (10 ml/kg i.p), Group 2:vincristine (0.1 mg/kg i.p) for 14 days (24,25), Group 3:Vincristine+Gabapentin (75 mg/kg p.o), Group 4, 5 and 6:Vincristine+Thymoquinone (10, 20, 30 mg/kg/day orally) for 14 days 15 minutes before vincristine (26,27). Thermal and mechanical tests were performed on days 1, 6, and 14 following the vincristine injection to determine the nociceptive threshold (28).…”

Genetic risk factors for bortezomib-induced peripheral neuropathy in an Asian population: A genome-wide association study in South Korea

“…Over the past decades, the molecular pathophysiology of BIPN has predominantly been studied using animal models. [19][20][21][22][23][24] Various pathways, including axonal degeneration, mitochondrial or endoplasmic reticulum dysfunction, ion channel abnormalities, apoptosis, neuroin ammation, and more, have been implicated in BIPN development. [25][26][27] Many of these pathways parallel our ndings, speci cally the involvement of immune system modulation, endosomal processes, solute carrier systems, glucose/sphingolipid metabolism, ion channels, and ligand-gated ion channels.…”