Animal Models of Diabetes-Related Male Hypogonadism

Dimakopoulou, Anastasia; Jayasena, Channa N.; Radia, Utsav K; Algefari, Metab; Minhas, Suks; Oliver, Nick; Dhillo, Waljit S.

doi:10.3389/fendo.2019.00628

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…As the elderly suffer from chronic diseases, they also suffer from CHF and diabetes. Most studies show that the rate of cognitive impairment is as high as 75%–80% [ 18 ]. 25%–75% of CHF patients have serious cognitive impairment, which seriously threatens the quality of life of the elderly, resulting in lower compliance and lower self-care ability.…”

Section: Introductionmentioning

confidence: 99%

Effect of Chronic Heart Failure Complicated with Type 2 Diabetes Mellitus on Cognitive Function in the Elderly

Liu

Meng

Dong

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effect of chronic heart failure complicated with type 2 diabetes mellitus on cognitive function in the elderly. Methods. 600 patients with chronic heart failure were selected from January 2018 to January 2021. All patients were divided into observation group (A) and control group (B). A was chronic heart failure complicated with type 2 diabetes mellitus group. B was chronic heart failure group. The clinical effects of the two groups were observed. Results. Compared with the clinical indexes during and after operation, there were differences in operation time, postoperative recovery time, and treatment cost between A and B, but the difference is not significant (all P > 0.05 ). LVEF cardiac function index score, LVEF score of A compared with B, the difference was statistically significant ( P < 0.05 ). The MMSE score and MoCA score of the two groups were compared. Before operation, the MMSE score and MoCA score of A were lower than those of B, and the difference was statistically significant ( P < 0.05 ). After operation, the MMSE score and MoCA score in B were significantly higher than those in B, but the increasing trend of MMSE score and MoCA score in B was significantly higher than that in A ( P < 0.05 ). Comparison of HAMA score and HAMD score: before operation, the HAMA score and HAMD score were higher in A, but the difference is not significant ( P > 0.05 ). After operation, the scores of HAMA and HAMD in A and B decreased significantly, but the difference is not significant ( P > 0.05 ). Multivariate analysis showed that the fasting blood glucose and glycosylated hemoglobin were the risk factors of cognitive impairment. Conclusion. Type 2 diabetes mellitus in elderly patients with chronic heart failure will further aggravate cognitive impairment, and type 2 diabetes is an important independent risk factor affecting cognitive function, which accelerates cognitive impairment and significantly reduces the executive ability of elderly patients with chronic heart failure, resulting in a significant decline in patients’ ability to understand and apply information.

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Section: Introductionmentioning

confidence: 99%

Effect of Chronic Heart Failure Complicated with Type 2 Diabetes Mellitus on Cognitive Function in the Elderly

Liu

Meng

Dong

2022

Evidence-Based Complementary and Alternative Medicine

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“…Decreases were shown in serum testosterone concentrations of the DC rats which remained below those of normal control (figure 3C); an observation that was in line with previous publications. 34 These also corresponded with the decreased levels recorded for HDL-C. 35 Slight but insignificant increases in the sex hormone's concentrations, from AE to EE groups were observed above those of DC (AE, p = 0.989; EE, p = 0.807), but these values were significantly below those of control rats (p < 0.001 in both extracts). However, the non-significant increase in the level of testosterone, indicated a possible restoration that could occur if the extracts (particularly EE) were to be administered beyond the experimental duration.…”

Section: Resultsmentioning

confidence: 56%

Antidiabetic Investigations of Aqueous and Ethanol Extracts of Terminalia macroptera (Guill. & Perr.) Stem Bark in Streptozotocin-Induced Diabetic Wistar Rats

2021

TJNPR

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Diabetes mellitus (DM) is an anomaly in sugar metabolism that is characterized by the destruction of blood tissues and peripheral organs following chronic high glucose concentration that are due largely to non-secretion of insulin by pancreas or the non-recognition of same by receptors. 1 The disease partly has its origin at the molecular level, but it is expressed physiologically in insulin changes as well as in sustained high glucose levels. These changes lead to alterations in serum lipid profiles (SLP) which result in serious complications and failure of various organs. 2 Oral synthetic hypoglycemic agents and insulin are usually used for the treatment of this metabolic derangement, however, their use over time has diminished due in part to their undesirable side effects such as the development of hypoglycemia, angiopathy, and induction of obesity. 3 The actions of these drugs have shown that they are useful for the management of the disease but not curative. 4 Consequently, scientists are in pursuit of more therapeutic agents that can permanently stop the plague.

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“…These results offered the possibility that hypogonadism in males with type 2 diabetes might be related to testes dysfunction and reduced testosterone production induced by hyperglycaemia and IR. It was supported by experimental evidence from several studies from cell and animal models 52 . In streptozotocin‐induced diabetes mice and rats, low testosterone concentration was likely to be related to the reduced number and impaired function of Leydig cells in the testes, which lead to decreased androgen biosynthesis 53,54 .…”

Section: Discussionmentioning

confidence: 87%

“…It was supported by experimental evidence from several studies from cell and animal models. 52 In streptozotocin-induced diabetes mice and rats, low testosterone concentration was likely to be related to the reduced number and impaired function of Leydig cells in the testes, which lead to decreased androgen biosynthesis. 53,54 Another study from cultured Sertoli cells prepared from rats showed that diabetesrelated effects on testicular function may be a consequence of reduced insulin signalling and defective energy metabolism.…”

Section: Discussionmentioning

confidence: 99%

The occurrence of hypogonadotropic hypogonadism in Chinese men with type 2 diabetes

Zhou

Tian

Wang

et al. 2022

Clinical Endocrinology

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Context The previous studies showed that hypogonadotropic hypogonadism (HH) occurred commonly in men with type 2 diabetes. However, since all the cohorts tested were from American and European studies, the occurrence of HH/nongonadal illness (NGI) in Chinese populations is unclear. Objective The study aimed to explore the occurrence of HH/NGI in Chinese men with type 2 diabetes. Furthermore, the correlative factors and predictors of hypogonadism were investigated. Design We conducted a cross‐sectional study of 637 Chinese men with type 2 diabetes aged 20–75 years in our clinic. The prevalence of HH/NGI was investigated by measuring serum total testosterone (TT), sex hormone‐binding globulin (SHBG), luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) in the enrolled subjects. Free testosterone (FT) was calculated by using SHBG and TT levels and hypogonadism was defined as TT lower than 10.4 nmol/L and calculated FT (cFT) lower than 0.225 nmol/L. The LH cut‐off value for defining HH/NGI was 9.4 mIU/ml. Results The results suggested that 31.9% of male Chinese type 2 diabetes patients had hypogonadism and 26.5% of subjects in our cohort were determined as HH/NGI. The occurrence of hypogonadism was markedly correlated with body mass index (BMI). There was a significant association between TT, cFT and SHBG levels with BMI. TT levels are inversely correlated with BMI and homeostasis model assessment‐estimated insulin resistance (HOMA‐IR) while positively related with SHBG. The cFT levels were inversely correlated with age, LH, FSH, BMI and HOMA‐IR. Multiple regression analysis suggested that SHBG, BMI and HOMA‐IR were significant predictors of TT and cFT. Conclusion Our present study offered the first evidence that the occurrence of HH/NGI in Chinese male type 2 diabetes was 26.5%. TT and cFT were significantly correlated with BMI, SHBG and HOMA‐IR in Chinese men with type 2 diabetes.

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Animal Models of Diabetes-Related Male Hypogonadism

Cited by 10 publications

References 29 publications

Effect of Chronic Heart Failure Complicated with Type 2 Diabetes Mellitus on Cognitive Function in the Elderly

Effect of Chronic Heart Failure Complicated with Type 2 Diabetes Mellitus on Cognitive Function in the Elderly

Antidiabetic Investigations of Aqueous and Ethanol Extracts of Terminalia macroptera (Guill. & Perr.) Stem Bark in Streptozotocin-Induced Diabetic Wistar Rats

The occurrence of hypogonadotropic hypogonadism in Chinese men with type 2 diabetes

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