Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis

Zhan, Xi; Wang, Fan; Bi, Yan; Ji, Baoan

doi:10.1152/ajpgi.00372.2015

Cited by 43 publications

(39 citation statements)

References 170 publications

(180 reference statements)

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“…The production of inflammatory cytokines such as TNF-α, IL-1β and IL-6 can promote and propagate the inflammatory reaction and injurious manner [39]. The attained data showed that the levels of TNF-α and IL-1β were down-regulated in the gut homogenate of Prednisolone treated rats more than Hypiran groups.…”

Section: Gross Appearance Of the Colonic Mucosa In Experimental Groupsmentioning

confidence: 88%

The Beneficial Effects of Hypiran in Ameliorating Rat Model of Ulcerative Colitis

Froushani

Mashouri

2018

Zahedan J Res Med Sci

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Background: Different studies have been done on Hypericum anti-depressant effects, but only a few ones have documented in vivo anti-inflammatory properties of Hypericum following systemic administration. Objectives: This survey was designed to evaluate the potential effects of Hypiran, a hydro-alcoholic extract of St. John's Wort, for the treatment and controlling inflammation in animal models of ulcerative colitis. Methods: In this experimental study, ulcerative colitis was induced in the male Wistar rats by luminal instillation of acetic acid. Animals in the treatment groups received Hypiran (150 mg/kg PO) or Prednisolone (4 mg/kg PO) daily for 10 consecutive days. At the end, the rats were sacrificed and the disease activity index, the levels of malondialdehyde, myeloperoxidase, nitric oxide, total protein and the concentration of TNF-α, IL-1β and IL-6 were assessed in the colonic homogenized tissue specimens. Results:The results showed that both therapies with Hypiran and Prednisolone could regress the clinical scores and the mortality rate of ulcerative colitis in a comparable manner. The levels of TNF-α, IL-1β and myeloperoxidase activity were down-regulated in the guts of Prednisolone treated rats more than Hypiran groups. Nevertheless, Hypiran decreased the levels of IL-6, nitric oxide and malondialdehyde more significantly than Prednisolone. Conclusions: Collectively, these data suggest that the Hypiran may be used as a natural source to alleviate the signs of rat model of ulcerative colitis.

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Section: Gross Appearance Of the Colonic Mucosa In Experimental Groupsmentioning

confidence: 88%

The Beneficial Effects of Hypiran in Ameliorating Rat Model of Ulcerative Colitis

Froushani

Mashouri

2018

Zahedan J Res Med Sci

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“…Although they have the advantage of investigating responses in the absence of inflammation and changes in blood flow, their acinar cell phenotype disappears within hours of being placed in culture, making them useful for examining only early pancreatitis responses. Intact animal models of pancreatitis have been generated in many species including dogs, cats, guinea pigs, and even zebra fish 13, 14. Although many species have been used, rats and mice are used most commonly.…”

Section: Animal Models Of Clinical Acute Pancreatitismentioning

confidence: 99%

Do Animal Models of Acute Pancreatitis Reproduce Human Disease?

Gorelick

Lerch

2017

Cellular and Molecular Gastroenterology and Hepatology

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Acute pancreatitis is currently the most common cause of hospital admission among all nonmalignant gastrointestinal diseases. To understand the pathophysiology of the disease and as a potential step toward developing targeted therapies, attempts to induce the disease experimentally began more than 100 years ago. Recent decades have seen progress in developing new experimental pancreatitis models as well as elucidating many underlying cell biological and pathophysiological disease mechanisms. Some models have been developed to reflect specific causes of acute pancreatitis in human beings. However, the paucity of data relating to the molecular mechanisms of human disease, the likelihood that multiple genetic and environmental factors affect the risk of disease development and its severity, and the limited information regarding the natural history of disease in human beings make it difficult to evaluate the value of disease models. Here, we provide an overview of key models and discuss our views on their strengths for characterizing cell biological disease mechanisms or for identifying potential therapeutic targets. We also acknowledge their limitations.

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“…Nevertheless, a recent study showed a significant correlation of proteomic alterations in acinar cells in mice with caerulein-induced CP and human CP tissue, substantiating the caerulein model as a model of relevance for investigating the pathogenesis of CP (29). The main reasons for the model still being used widely are its ease of performance, its noninvasive methods, its high reproducibility and applicability in many species, and, currently, in transgenic and knockout mice, its aggravation of the present phenotype (11).…”

Section: Caerulein-induced Cpmentioning

confidence: 78%

“…Behavioral tests to examine pain were conducted in several studies, mostly in the framework of drug treatment studies (27,28), showing a significant increase in pain sensation compared with that in control animals. The pancreatitis induced in this model is considered mild, and pancreatic histology of the caerulein-treated mice normalizes after 3-6 wk (11). Furthermore, the clinical relevance of that model is questionable-although some patients develop CP from recurrent AP, the pathogenesis of human CP is not associated with hyperstimulation by cholecystokinin (4).…”

Section: Caerulein-induced Cpmentioning

confidence: 99%

“…An ideal CP model should demonstrate all those factors. A number of excellent reviews (4)(5)(6)(8)(9)(10)(11) exist about animal models of CP; however, the mentioned, sine qua non pain syndrome is rarely addressed. Nociceptive, reflexive behaviors, such as mechanical or thermal sensitivity at the abdomen (12), and explorative behavior, investigated in the open field test (13), have been adopted as indicators of the pain state of mice and rats with CP (12,14,15).…”

Section: Introductionmentioning

confidence: 99%

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Genetically inducedvs.classical animal models of chronic pancreatitis: a critical comparison

et al. 2018

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Chronic pancreatitis (CP) is an utmost complex disease that is pathogenetically linked to pancreas-intrinsic ( e.g., duct obstruction), environmental-toxic ( e.g., alcohol, smoking), and genetic factors. Studying such a complex disease naturally requires validated experimental models. In the past 2 decades, the various animal models of CP usually addressed either the pancreas-intrinsic ( e.g., the caerulein model), the environmental-toxic ( e.g., diet-induced models), or the genetic component of CP. As such, these models were far from mirroring CP in its full spectrum, and the correct choice of models was vital for valid scientific conclusions on CP. The quest for mechanistic, genetic models gave rise to models based on gene modification and transgene insertion, such as the PRSS1 and the IL-1β/IL-1β models. Recently, we witnessed the development of highly exciting models that rely on the importance of autophagy in CP, that is, the murine pancreas-specific Atg5 and LAMP2 knockout models. Today, critical comparison of these several models is more important than ever for guiding research on CP in an efficient direction. The present review outlines the characteristics of the new genetic models in comparison with the well-known classic models for CP, notes the caveats in the choice of models, and also indicates novel directions for model development.-Klauss, S., Schorn, S., Teller, S., Steenfadt, H., Friess, H., Ceyhan, G. O., Demir, I. K. Genetically induced vs. classical animal models of chronic pancreatitis: a critical comparison.

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Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis

Cited by 43 publications

References 170 publications

The Beneficial Effects of Hypiran in Ameliorating Rat Model of Ulcerative Colitis

The Beneficial Effects of Hypiran in Ameliorating Rat Model of Ulcerative Colitis

Do Animal Models of Acute Pancreatitis Reproduce Human Disease?

Genetically inducedvs.classical animal models of chronic pancreatitis: a critical comparison

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