Animal models of head and neck squamous cell carcinoma

Supsavhad, Wachiraphan; Dirksen, Wessel P.; Martin, Chelsea K.; Rosol, Thomas J.

doi:10.1016/j.tvjl.2015.11.006

Cited by 81 publications

(108 citation statements)

References 90 publications

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“…U młodych psów wirus brodawczaka (CPV -canine papilloma virus) może stanowić przyczynę indukcji HNSCC (28). W przy-padku kotów nowotwory jamy ustnej stanowią 10% wszystkich diagnozowanych u nich nowotworów, z czego 75% to OSCC (35,45).…”

Section: Artykuł Przeglądowy Reviewunclassified

“…Najczęściej stosowanymi w tych badaniach zwierzętami są: chomik, mysz i szczur (45). Idealnym modelem zwierzęcym OSCC jest taki, który powstaje spontanicznie -tutaj do badań in vivo dogodnymi modelami mogą być pies i kot, u których OSCC powstają właśnie samoistnie.…”

Section: Artykuł Przeglądowy Reviewunclassified

“…Idealnym modelem zwierzęcym OSCC jest taki, który powstaje spontanicznie -tutaj do badań in vivo dogodnymi modelami mogą być pies i kot, u których OSCC powstają właśnie samoistnie. Dodać należy, że HNSCC z większą częstotliwością rozwija się u starszych kotów niż psów (45).…”

Section: Artykuł Przeglądowy Reviewunclassified

“…Do badań interakcji pomiędzy nowotworem, mikrośrodowiskiem i odpornością gospodarza stosuje się model chomika, u którego w łatwy sposób można prześledzić rozwój guza in vivo (45). U chomika, jako modelu HNSCC, pewne kontrowersje budzi fakt, iż zwierzę to posiada worki policzkowe, co może nie w pełni odzwierciedlać patofizjologię i spontaniczny rozwój HNSCC u człowieka (45).…”

Section: Artykuł Przeglądowy Reviewunclassified

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Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research

Bryja

Dyszkiewicz-Konwińska

Budna

et al. 2017

Medycyna Weterynaryjna

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SummaryNeoplastic diseases are a challenge to modern medicine. The understanding of histological, molecular and genetic transformation leading to cancer is essential in establishing methods for earlier diagnosis and better treatment of oral cavity cancer, not only in humans but also in animals -in particular, in dogs and cats, which develop oral cancer spontaneously. There are several methods of cancer modeling that expand research capabilities. The following overview discusses different methods of inducing carcinogenesis in animals and presents animal models used in the study of carcinogenesis. Publications reviewed in the paper discuss markers used in the diagnosis of oral cancer and describe the concept of cancer stem cells.

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Section: Artykuł Przeglądowy Reviewunclassified

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Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research

Bryja

Dyszkiewicz-Konwińska

Budna

et al. 2017

Medycyna Weterynaryjna

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“…Supsavhad et al recently reviewed available animal models of head and neck squamous cell carcinomas [39]. Of note is the development of oral premalignant lesions in carcinogen-induced models that can be leveraged for preclinical chemoprevention studies.…”

Section: Special Reportmentioning

confidence: 99%

Prognostic Factors, Predictive Markers and Cancer Biology: The Triad for Successful Oral Cancer Chemoprevention

Novaes

William

2016

Future Oncol.

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Oral squamous cell carcinomas represent a significant cancer burden worldwide. Unfortunately, chemoprevention strategies investigated to date have failed to produce an agent considered standard of care to prevent oral cancers. Nonetheless, recent advances in clinical trial design may streamline drug development in this setting. In this manuscript, we review some of these improvements, including risk prediction tools based on molecular markers that help select patients most suitable for chemoprevention. We also discuss the opportunities that novel preclinical models and modern molecular profiling techniques will bring to the prevention field in the near future, and propose a clinical trials framework that incorporates molecular prognostic factors, predictive markers and cancer biology as a roadmap to improve chemoprevention strategies for oral cancers. A major global health concern, oral squamous cell carcinoma (OSCC) is currently the 13th most common cancer worldwide, with an estimate of 300,000 new cases, and 145,000 deaths each year [1]. Tobacco, alcohol and/or betel nut exposure are well-established risk factors for OSCC. Interruption of carcinogen use is an obvious key intervention to reduce oral cancer incidence ('primary' prevention). Nonetheless, OSCC risk remains elevated even after alcohol and tobacco cessation and may take up to 20 years to reach baseline levels [2] illustrating the need for development of approaches that can interrupt/reverse the process of carcinogenesis after initiation, but before full malignant transformation. Furthermore, an increase in the incidence of oral cancer in women with no clear etiologic factors has been observed [3], supporting the need for improved understanding of molecular pathways dysregulation that lead to cancer and how they could be targeted for OSSC prevention.Oral potentially malignant lesions (OPMLs) are often clinically characterized as leukoplakia and/or erythroplakia. Histologically, these lesions frequently exhibit hyperplasia, hyperkeratosis and/or varying degrees of dysplasia (i.e., intraepithelial neoplasias [IEN]). OPMLs are not obligate precursors of oral cancers, but they are estimated to precede development of at least 7% of OSCC [4] OPMLs are in and of themselves risk factors for oral cancer, but have a variable frequency of malignant transformation, depending on other clinical, demographic, etiologic, histological and/or molecular features [5]. The anatomic accessibility of OPMLs for examination and biopsies provides an opportunity for clinical and translational studies of oral carcinogenesis. In this review, we will summarize the recent advances and future perspectives of molecularly focused strategies of oral cavity cancers chemoprevention, many of which stem from OPML-based research. We will specifically

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Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data

Zohud,

Lone,

Nashef

et al. 2023

Anim Models and Exp Med

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Head and neck squamous cell cancer (HNSCC) is a leading global malignancy. Every year, More than 830 000 people are diagnosed with HNSCC globally, with more than 430 000 fatalities. HNSCC is a deadly diverse malignancy with many tumor locations and biological characteristics. It originates from the squamous epithelium of the oral cavity, oropharynx, nasopharynx, larynx, and hypopharynx. The most frequently impacted regions are the tongue and larynx. Previous investigations have demonstrated the critical role of host genetic susceptibility in the progression of HNSCC. Despite the advances in our knowledge, the improved survival rate of HNSCC patients over the last 40 years has been limited. Failure to identify the molecular origins of development of HNSCC and the genetic basis of the disease and its biological heterogeneity impedes the development of new therapeutic methods. These results indicate a need to identify more genetic factors underlying this complex disease, which can be better used in early detection and prevention strategies. The lack of reliable animal models to investigate the underlying molecular processes is one of the most significant barriers to understanding HNSCC tumors. In this report, we explore and discuss potential research prospects utilizing the Collaborative Cross mouse model and crossing it to mice carrying single or double knockout genes (e.g. Smad4 and P53 genes) to identify genetic factors affecting the development of this complex disease using genome‐wide association studies, epigenetics, microRNA, long noncoding RNA, lncRNA, histone modifications, methylation, phosphorylation, and proteomics.

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Animal models of head and neck squamous cell carcinoma

Cited by 81 publications

References 90 publications

Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research

Carcinogenesis in mammalian oral mucosa from the perspective of biomedical research

Prognostic Factors, Predictive Markers and Cancer Biology: The Triad for Successful Oral Cancer Chemoprevention

Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model, cellular platform, and clinical human data

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