Animal Models of Helicobacter Gastritis

Eaton, Kathryn A.

doi:10.1007/978-3-642-60013-5_8

Cited by 21 publications

(32 citation statements)

References 131 publications

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“…*P Ͻ 0.05 and **P Ͻ 0.01 compared with reference (Ref. (12,13,20,31,38,40,46). One study reported gastric lymphoid follicular hyperplasia in response to H. felis infection (46), but in the vast majority of studies these bacteria were found not to induce inflammatory cell infiltration in the gastric mucosa.…”

Section: Discussionmentioning

confidence: 82%

“…One study reported gastric lymphoid follicular hyperplasia in response to H. felis infection (46), but in the vast majority of studies these bacteria were found not to induce inflammatory cell infiltration in the gastric mucosa. These bacteria are therefore considered to be saprophytes (12,13,38). In the present study, the effect of H. pylori was analyzed in cats that had gastric H. felis infections and in cats free of gastric pathogens.…”

Section: Discussionmentioning

confidence: 99%

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Putative effect ofHelicobacter pyloriand gastritis on gastric acid secretion in cat

Sobhani

Cañedo

Alchepo

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Putative effect ofHelicobacter pyloriand gastritis on gastric acid secretion in cat

Sobhani

Cañedo

Alchepo

et al. 2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Several potential factors including urease, cag A, flagella and chemotactic factors have been reported to be involved in the colonization of H. pylori in the stomach of animals (6,7,24). However, little work has been done on the colonization of H. pylori related to energy metabolism using disrupted mutant strains.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, no colonization occurred in the stomach of nude mice infected with this mutant. The motility of H. pylori is one of the important virulent factors, as no colonization in the stomach is observed in mice infected with a strain with disrupted flagella (6). Thus, the failure of Δput A to cause colonization may be due to its loss of motility.…”

Section: Methodsmentioning

confidence: 99%

Possible involvement of put A gene in Helicobacter pylori colonization in the stomach and motility

et al. 2008

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H. pylori is a gram-negative bacterium associated with gastric inflammation and peptic ulcer and considered a risk factor for gastric cancer in its natural habitat. However, the energy metabolism of H. pylori in the stomach remains to be clarified. H. pylori shows rather high respiratory activity with L-proline and significantly large amounts of L-proline are present in the gastric juice from H. pylori infected patients. We constructed a disrupted mutant of the put A gene, which encodes the proline utilization A (Put A) flavin-linked enzyme, in order to examine the role of put A in the gastric colonization of H. pylori. The put A disrupted mutant, ΔputA, was constructed by inserting a chloramphenicol resistant gene into put A. Δput A did not show respiratory activity using L-proline and could not incorporate L-proline into cells. Δput A also did not show motility in response to amino acids and did not display the swarming activity observed with the wild-type. Δput A had lost its ability to colonize the stomach of nude mice, an ability possessed by the wild-type. These findings indicate that put A may play an important role in H. pylori colonization on the gastric mucus layer.

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“…Various animal models have been proposed for the study of the pathogenesis of H. pylori-induced lesions (3,6). Recently we showed that in conventional beagle dogs, colonization with H. pylori and disease can be monitored in the same individuals without any need for necropsy (17).…”

mentioning

confidence: 99%

Immunohistochemical Study of Lymphocyte Populations Infiltrating the Gastric Mucosa of Beagle Dogs Experimentally Infected withHelicobacter pylori

Rossi

Fortuna

Pancotto³

et al. 2000

Infect Immun

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Animal Models of Helicobacter Gastritis

Cited by 21 publications

References 131 publications

Putative effect ofHelicobacter pyloriand gastritis on gastric acid secretion in cat

Putative effect ofHelicobacter pyloriand gastritis on gastric acid secretion in cat

Possible involvement of put A gene in Helicobacter pylori colonization in the stomach and motility

Immunohistochemical Study of Lymphocyte Populations Infiltrating the Gastric Mucosa of Beagle Dogs Experimentally Infected withHelicobacter pylori

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