Animal models of myocardial infarction: Mainstay in clinical translation

Kumar, Mukesh; Kasala, Eshvendar Reddy; Bodduluru, Lakshmi Narendra; Dahiya, Vicky; Sharma, Dinesh; Kumar, Vikas; Lahkar, Mangala

doi:10.1016/j.yrtph.2016.03.005

Cited by 60 publications

(50 citation statements)

References 97 publications

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“…Rat studies also enable greater quantities of myocardial tissue for post-mortem histological analyses. 53 However, costs associated with rat models may be higher and favorable results may not always be reproducible in clinical studies. Moreover, although transgenic rat models exist, a high cost is associated with generating and maintaining these colonies and there are appreciably fewer models in rats than in mice.…”

Section: Small Animal Cardiac Injectionsmentioning

confidence: 99%

Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials

Chen

Wang

Chung

et al. 2017

ACS Biomater. Sci. Eng.

332

276

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Injectable hydrogels have gained popularity as a vehicle for the delivery of cells, growth factors, and other molecules to localize and improve their retention at the injection site, as well as for the mechanical bulking of tissues. However, there are many factors, such as viscosity, storage and loss moduli, and injection force, to consider when evaluating hydrogels for such applications. There are now numerous tools that can be used to quantitatively assess these factors, including for shear-thinning hydrogels because their properties change under mechanical load. Here, we describe relevant rheological tests and ways to measure injection force using a force sensor or a mechanical testing machine toward the evaluation of injectable hydrogels. Injectable, shear-thinning hydrogels can be used in a variety of clinical applications, and as an example we focus on methods for injection into the heart, where an understanding of injection properties and mechanical forces is imperative for consistent hydrogel delivery and retention. We discuss methods for delivery of hydrogels to mouse, rat, and pig hearts in models of myocardial infarction, and compare methods of tissue postprocessing for hydrogel preservation. Our intent is that the methods described herein can be helpful in the design and assessment of shear-thinning hydrogels for widespread biomedical applications.

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Section: Small Animal Cardiac Injectionsmentioning

confidence: 99%

Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials

Chen

Wang

Chung

et al. 2017

ACS Biomater. Sci. Eng.

332

276

View full text Add to dashboard Cite

show abstract

“…Pigs resemble humans in the context of minimal preexisting coronary collaterals and similar coronary anatomy and physiology and, therefore, are commonly used in animal experiments of myocardial infarction. 25 In this study, we compared the hyperemic effects of different pharmaceutical agents on IMR measurements using a pig model.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and safety of intracoronary papaverine, alprostadil, and high dosages of nicorandil and adenosine triphosphate for measurement of the index of coronary microcirculatory resistance in a pig model

et al. 2019

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This study was supported by BEIJING TIDE PHARMACEUTICAL CO., LTD. (Beijing, China) but was designed and implemented independently by Guangzhou General Hospital of Guangzhou Military Command. We declare that none of the authors has any financial and personal relationships with other people or organizations that can inappropriately influence the quality of the work presented in this manuscript. There is no professional or other personal interest of any nature or kind in any product, service and/or company that may be construed as influencing the position presented in this manuscript.

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“…Working mode -The flow of bloods and metabolites into coronaries artery is determined by the contraction and performance of the heart. It can also be used for in vivo perfusion (Kumar et al, 2016). In a standard langendorff assembly, the heart is clamped via aorta against the cannula.…”

Section: Langendorff Heart Modelmentioning

confidence: 99%

“…The Pharmacological intercessions are screened in an exact and controlled way. These models offers preferred advantages, for example, effortlessness, inexpensive miniaturisation, decreases animal use in experiments, utilize high-number of replica, quick/high throughput and generate reproducible data, enabling easy correlation with human diseases; cell models accessible for most tissue varieties, cell lines support reproducibility and encourage between lab examination (Kumar et al, 2016).…”

Section: In Vitro Models -Isolated Cardiac Cellsmentioning

confidence: 99%

A conglomeration of preclinical models related to myocardial infarction

Ahsan

Mahmood

Usmani

et al. 2020

Braz. J. Pharm. Sci.

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Cardiovascular diseases are the main source of death and morbidity in developed and developing nations. Animal models are required to propel our understanding of the pathogenesis, increase our knowledge, disease progress, and mechanism behind cardiovascular disorder, providing new approaches focused to improve the diagnostic and the treatment of these pathological conditions and additionally to test various therapeutic ways to deal with tissue regeneration and re-establish heart working following damage. A perfect model framework ought to be reasonable, effectively controlled, reproducible, and physiologically illustrative of human disease, show cardinal signs and pathology that resembles after the human ailment and ethically stable. The decision of selection of animal model should be considered precisely since it influences exploratory results and whether results of the research can be sensibly matched with the human. In this way, no specific technique splendidly reproduces the human disease, and relying upon the model, extra cost burden, resources, infrastructure and the necessity for technical hands, should also be kept under consideration. Here we have discussed and compiled various methods of inducing myocardial infarction in animals, basically by surgery, chemicals and through genetic modification, this may benefit the researchers in getting a complied data regarding various methods through which they can induce myocardial infarction in animals.

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Animal models of myocardial infarction: Mainstay in clinical translation

Cited by 60 publications

References 97 publications

Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials

Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials

Effectiveness and safety of intracoronary papaverine, alprostadil, and high dosages of nicorandil and adenosine triphosphate for measurement of the index of coronary microcirculatory resistance in a pig model

A conglomeration of preclinical models related to myocardial infarction

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