eCM 2001
DOI: 10.22203/ecm.v001a08
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Animal models of osteoporosis - necessity and limitations

Abstract: There is a great need to further characterise the available animal models for postmenopausal osteoporosis, for the understanding of the pathogenesis of the disease, investigation of new therapies (e.g. selective estrogen receptor modulators (SERMs)) and evaluation of prosthetic devices in osteoporotic bone. Animal models that have been used in the past include non-human primates, dogs, cats, rodents, rabbits, guinea pigs and minipigs, all of which have advantages and disadvantages. Sheep are a promising model … Show more

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Cited by 243 publications
(50 citation statements)
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“…20 In the present study, the analyses were limited to the trabecular bone microarchitecture of the distal epiphysis of the femurs as it is a region that is particularly sensitive to the effects of OVX and recognized as a key component of quality and bone strength (resistance), comparable to osteoporosis in humans and detectable by microtomography. 18,21,22,23,24 The results revealed low bone quality of the femurs of OVX rats compared with SHAM rats. However, the lack of a statistically significant difference between the groups in terms of trabecular thickness may be associated with trabecular thickening in osteoporotic rats as an attempt to compensate for the decrease in bone resistance produced by trabecular resorption.…”
Section: Discussionmentioning
confidence: 94%
“…20 In the present study, the analyses were limited to the trabecular bone microarchitecture of the distal epiphysis of the femurs as it is a region that is particularly sensitive to the effects of OVX and recognized as a key component of quality and bone strength (resistance), comparable to osteoporosis in humans and detectable by microtomography. 18,21,22,23,24 The results revealed low bone quality of the femurs of OVX rats compared with SHAM rats. However, the lack of a statistically significant difference between the groups in terms of trabecular thickness may be associated with trabecular thickening in osteoporotic rats as an attempt to compensate for the decrease in bone resistance produced by trabecular resorption.…”
Section: Discussionmentioning
confidence: 94%
“…By contrast, rabbits do have some inherent advantages as the osteoporosis animal model. For example, they achieve skeletal maturity shortly after reaching complete sexual development and show significant intracortical remodeling [43]. Thus, some researchers prefer rabbits as their ideal model.…”
Section: Discussionmentioning
confidence: 99%
“…The characteristics of human bone are best approximated by dog models; but substantial differences exist in the bone anatomy, microstructure, and remodeling between rabbit and humane [42]. Rat is unsuitable due to significant dissimilarities in bone structure [43]. …”
Section: Discussionmentioning
confidence: 99%