Animal Models of Photosensitivity: Clinical Significance and Windows into Mechanisms

Szabó, C. Ákos; Fischer, Andrea

doi:10.1007/978-3-319-05080-5_18

Cited by 4 publications

(3 citation statements)

References 60 publications

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“…Flickering stimuli are associated with large amplitude neural responses within the visual cortex (Gentile and Aguirre 2020); more precisely, the source of discomfort is transient abnormal synchronized activity of brain cells (Wilkins et al 2010). Photosensitive epilepsy has been documented not only in humans but also in baboons, dogs, and poultry, indicating a lack of species specificity (Corcoran et al 1979;Batini et al 2004;Da Silva and Leal 2017;Szabó and Fischer 2021).…”

Section: Introductionmentioning

confidence: 99%

The physiology of deterrence: Flicker vertigo and its application in avian management

Honda

2024

Preprint

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Human-bird conflicts are in a critical state, involving economic losses such as agricultural losses, bird strikes on aircraft and avian influenza. Traditional technologies leveraging bird vision and hearing often lose their effectiveness over time as birds become habituated to these stimuli. To address these challenges, our study introduces a novel countermeasure technology based on neurophysiology. The human brain reacts to flickering light, which can cause symptoms like headaches, nausea, and dizziness. In extremely rare cases, it can even lead to epilepsy. This led us to consider the possibility that similar stimuli could be applicable to birds. In our experiments conducted during the day, we used long-range flashlights. White flickering light had no effect on bird escape behavior. However, when cellophane film was attached to the flashlights to restrict the wavelength, the emitted red light induced escape behavior in birds. Additionally, employing two types of flashlights to generate flickering red+blue or red+green lights elicited escape behavior. However, the blue and green combination proved to be less effective. These results are highly similar to those found in human neurophysiology, showing that red light alone and the combination of red and blue lights have the most significant impact on the brain. By measuring the flight initiation distance (FID) of birds, we found that illuminated areas had a significantly higher FID (137m) compared to non-illuminated areas (12m). These findings suggest that applying principles of human physiology to wildlife management can offer new solutions for bird damage control.

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Section: Introductionmentioning

confidence: 99%

The physiology of deterrence: Flicker vertigo and its application in avian management

Honda

2024

Preprint

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“…To address this issue, non-human primate models are considered suitable models of nervous system diseases because the non-human primate brain has very similar genetic, neurochemical, neurophysiologic, and structural features to human brains [ 5 ]. Killam et al first described a non-human primate baboon model of photosensitive epilepsy in 1966, which was characterized by intermittent light stimulation (ILS)-induced seizures [ 6 , 7 ]. This is the first natural epileptic non-human primate model.…”

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confidence: 99%

A natural marmoset model of genetic generalized epilepsy

et al. 2022

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Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of current epilepsy models cannot fully mimic different types of epilepsy in humans, hence non-human primate models of epilepsy are required. The common marmoset (Callithrix jacchus) is a New World monkey that is widely used to study brain function. Here, we present a natural marmoset model of generalized epilepsy. In this unique marmoset family, generalized epilepsy was successfully induced by handling operations in some individuals. We mapped the marmoset family with handling-sensitive epilepsy and found that the epileptic phenotype can be inherited. These marmosets were more sensitive to the epilepsy inducers pentylenetetrazol. Using electrocorticogram (ECoG) recordings, we detected epileptiform discharge in marmosets with a history of seizures. In summary, we report a family of marmosets with generalized seizures induced by handling operations. This epileptic marmoset family provides insights to better understand the mechanism of generalized epilepsy and helps to develop new therapeutic methods.

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“…4-Cepa de pollos Fayoumi, son propensos a sufrir crisis provocadas visual o acústicamente, que se heredan en un patrón autosómico recesivo (Szabó and Fischer, 2021).…”

Section: Crisis Generalizada Crisis Parcialesunclassified

Efectos terapéuticos del Cannabidiol en la epilepsia: un estudio preclínico en el modelo animal de epilepsia audiogénica GASH/Sal

Cabral Pereira

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Biodisponibilidad del CBD en el modelo GASH/Sal. ______________________________________ Efectos de la administración aguda del CBD en las crisis audiogénicas del GASH/Sal ___________ Efectos de la administración crónica del CBD en las crisis audiogénicas del GASH/Sal. _________ Efectos de la coadmistración del CBD y valproato en el modelo GASH/Sal sobre las crisis audiógenas. _____________________________________________________________________ Potenciales efectos adversos de la administración del CBD y del valproato en el modelo GASH/Sal. ________________________________________________________________________________ Efectos del CBD en la expresión de genes relacionados con la actividad farmacológica del CBD. _

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Animal Models of Photosensitivity: Clinical Significance and Windows into Mechanisms

Cited by 4 publications

References 60 publications

The physiology of deterrence: Flicker vertigo and its application in avian management

The physiology of deterrence: Flicker vertigo and its application in avian management

A natural marmoset model of genetic generalized epilepsy

Efectos terapéuticos del Cannabidiol en la epilepsia: un estudio preclínico en el modelo animal de epilepsia audiogénica GASH/Sal

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