Animal Models of Sjögren’s Syndrome

Hoffman, Robert W.; Walker, Sara E.

doi:10.1007/978-3-642-50118-0_25

Cited by 4 publications

(1 citation statement)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A model system expressing additional MHC haplotypes known to favor the development of anti‐Ro antibodies would be needed to explore the reasons why the autoantibody responses we observed did not include anti‐Ro or anti‐La. Of note, anti‐Ro and anti‐La antibodies generally have not been observed in murine models of spontaneous SS (27–30) and have been induced along with sialoadenitis in mice only after repeated hyperimmunization with a non–TLR‐3 or non–TLR‐7 stimulatory adjuvant (31). It will be of interest in future studies to determine whether any of the antigens targeted in the U1 RNP autoantibody–reactive TLR‐3 −/− mouse we observed are also Y RNA–binding lupus autoantigens as identified by Fabini et al (11).…”

Section: Discussionmentioning

confidence: 99%

Differential tissue targeting of autoimmunity manifestations by Autoantigen‐Associated Y RNAs

Greidinger¹,

Zang²,

Martinez³

et al. 2007

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To assess the Y RNAs, a family of homologous RNAs that bind to the Ro autoantigen, for the ability to contribute to autoimmune disease by activating RNA-responsive Toll-like receptors (TLRs).Methods. Using cell lines expressing or stably transfected with TLR-3, TLR-7, or TLR-8, we determined the patterns of RNA-specific TLR activation by in vitro transcripts of all of the known murine and human Y RNAs. Next, 8-10-week-old female mice were exposed to a single 50-g subcutaneous injection of mouse Y1 or mouse Y3 RNA, and the effects were observed.Results

show abstract

Section: Discussionmentioning

confidence: 99%