Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

Zhao, Yu‐Qing; An, Yanxin; Zhou, Libo; Wu, Fan; Wu, Gaoyi; Wang, Jing; Chen, Lei

doi:10.3389/fphys.2022.859517

Cited by 16 publications

(34 citation statements)

References 171 publications

(172 reference statements)

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“…We will focus our review on rodent models. Since there are recent outstanding reviews available for rodent models of TMJ degeneration ( 43 , 52 , 53 ), we will focus on the aspects of the TMJ pain-degeneration relationship.…”

Section: Preclinical Studies For Tmjoa and Pain From Tmjmentioning

confidence: 99%

The degeneration-pain relationship in the temporomandibular joint: Current understandings and rodent models

et al. 2023

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Temporomandibular disorders (TMD) represent a group of musculoskeletal conditions involving the temporomandibular joints (TMJ), the masticatory muscles and associated structures. Painful TMD are highly prevalent and conditions afflict 4% of US adults annually. TMD include heterogenous musculoskeletal pain conditions, such as myalgia, arthralgia, and myofascial pain. A subpopulations of TMD patients show structural changes in TMJ, including disc displacement or degenerative joint diseases (DJD). DJD is a slowly progressing, degenerative disease of the TMJ characterized by cartilage degradation and subchondral bone remodeling. Patients with DJD often develop pain (TMJ osteoarthritis; TMJ OA), but do not always have pain (TMJ osteoarthrosis). Therefore, pain symptoms are not always associated with altered TMJ structures, which suggests that a causal relationship between TMJ degeneration and pain is unclear. Multiple animal models have been developed for determining altered joint structure and pain phenotypes in response to various TMJ injuries. Rodent models of TMJOA and pain include injections to induce inflammation or cartilage destruction, sustained opening of the oral cavity, surgical resection of the articular disc, transgenic approaches to knockout or overexpress key genes, and an integrative approach with superimposed emotional stress or comorbidities. In rodents, TMJ pain and degeneration occur during partially overlapping time periods in these models, which suggests that common biological factors may mediate TMJ pain and degeneration over different time courses. While substances such as intra-articular pro-inflammatory cytokines commonly cause pain and joint degeneration, it remains unclear whether pain or nociceptive activities are causally associated with structural degeneration of TMJ and whether structural degeneration of TMJ is necessary for producing persistent pain. A thorough understanding of the determining factors of pain-structure relationships of TMJ during the onset, progression, and chronification by adopting novel approaches and models should improve the ability to simultaneously treat TMJ pain and TMJ degeneration.

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Section: Preclinical Studies For Tmjoa and Pain From Tmjmentioning

confidence: 99%

The degeneration-pain relationship in the temporomandibular joint: Current understandings and rodent models

et al. 2023

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“…There are also agents used other than MIA, but the use of MIA was preferred in the study because it can mimic both structural and cellular changes on the joint surface and the lesions formed are similar to osteoarthritis in humans. 31,32 During the design of the present study, we realised that female rats were used in some similar studies in the literature. [26][27][28]33 In our study, male rats were preferred so that no hormonal effect may imposed on the results.…”

Section: Discussionmentioning

confidence: 99%

“…Monosodium iodoacetate was preferred as the chemical agent to induce osteoarthritis formation. There are also agents used other than MIA, but the use of MIA was preferred in the study because it can mimic both structural and cellular changes on the joint surface and the lesions formed are similar to osteoarthritis in humans 31,32 …”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis

Acibadem

Keskinruzgar

Bozdağ

et al. 2022

J of Oral Rehabilitation

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Temporomandibular disorder (TMD) appears in many forms, from disturbances of the surrounding muscles to intra-temporomandibular joint (TMJ) irregularities. Depending on the habits of the patients, the stress level and the progression of the disease, these disorders can turn into TMJ osteoarthritis (TMJ-OA), which is characterised by the deterioration and degeneration of the bone and cartilage tissue in the joint. TMJ osteoarthritis is a very painful condition that negatively affects the patient's quality of life. 1 In TMJ-OA, cartilage degeneration, destruction/osteophyte formations in subchondral bone and synovitis are observed. 2 Pain in the anterior ear region, crepitus during jaw function and pain on the bilateral palpation are clinical symptoms of TMJ-OA. 3 The prevalence of TMJ-OA has been shown to be 8%-16%. The average age of onset is 18-45. 2,4 There are subtypes of TMJ-OA. Primary TMJ-OA is the type that develops from the TMD background, and its incidence varies between 18% and 84%. 5 This indicates that patients with TMD are also candidates for TMJ-OA.In the treatment of TMJ-OA, various treatment options are used, from conservative methods to advanced surgery. Among these

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“…Intra-articular injection is a well-characterized preclinical model which induces OA by intra-articular inflammation, cytotoxicity, and direct cartilage damage 5,6,[9][10][11][12][13][14] . While it is easy to perform, its pathogenic mechanism differs from human TMJ OA and is only suitable for study of pain and treatment response 15,16 .…”

Section: Introductionmentioning

confidence: 99%

“…Animal models play a crucial role in understanding the complex TMJ OA disease progression and evaluating new therapeutic interventions. However, lack of a reliable in vivo model makes the research into the pathophysiology of TMJ OA is relatively restricted 5,6 . Besides genetically-induced animal models 7,8 , which could be time-consuming and expensive, and do not induce inflammation in the synovial capsule.…”

Section: Introductionmentioning

confidence: 99%

A Novel Burn / Synovectomy Mouse Model for Temporomandibular Joint Osteoarthritis

Hsu

2023

Preprint

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Temporomandibular Disorders (TMDs) is present in 33% of the U.S. population. Currently available animal models do not faithfully simulate the native disease progression of TMJ OA. The initiation of TMJ OA requires both local trauma and systemic inflammation. In this study, we present a novel mouse model which reproduces these two conditions. This is achieved by a procedure involving both synovectomy (local trauma) and a distant burn injury (systemic inflammation). Its efficacy at inducing TMJ OA was assessed with histomorphology and radiographic evaluation at 1,3, and 9 weeks after the procedure. We found that burn/synovectomy mice demonstrated significantly more degenerative changes in TMJ than uninjured control mice or synovotomy mice. The observed histology in burn/synoectomy mice mimicked native TMJ OA disease progression in a faithful manner. This animal model is invaluable in future research of the mechanism and risk factors of TMJ OA.

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Animal Models of Temporomandibular Joint Osteoarthritis: Classification and Selection

Cited by 16 publications

References 171 publications

The degeneration-pain relationship in the temporomandibular joint: Current understandings and rodent models

The degeneration-pain relationship in the temporomandibular joint: Current understandings and rodent models

Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis

A Novel Burn / Synovectomy Mouse Model for Temporomandibular Joint Osteoarthritis

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