Animal models to study pathogenesis and treatments of cardiac disorders in rheumatoid arthritis: Advances and challenges for clinical translation

Kessler, JA; Totoson, Perle; Devaux, Sylvie; Moretto, Johnny; Wendling, Daniel; Demougeot, Céline

doi:10.1016/j.phrs.2021.105494

Cited by 5 publications

(3 citation statements)

References 105 publications

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“…In recent studies, researchers used the MR analysis, and it was revealed that patients with RA were at the increased risk of coronary artery disease (CAD), angina, hypertension, heart attack, arrhythmia, and stroke (10,35). Kessler et al concluded that IHD, non-IHD, and arrhythmia were the leading causes of cardiovascular complications in RA patients (36). The results of the present study indicated RA did not increase the risk of arrhythmia and AF.…”

Section: Discussionsupporting

confidence: 45%

Relationship between rheumatoid arthritis and cardiovascular comorbidity, causation or co-occurrence: A Mendelian randomization study

Min

Chao

Mei

et al. 2023

Front. Cardiovasc. Med.

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BackgroundIn recent years, the incidence rates of rheumatoid arthritis (RA) and heart disease (HD) have noticeably increased worldwide. Previous studies have found that patients with RA are more likely to develop HD, while the cause and effect have still remained elusive. In this study, Mendelian randomization (MR) analysis was used to indicate whether there was a potential association between RA and HD.MethodsData of RA, ischemic heart disease (IHD), myocardial infarction (MI), atrial fibrillation (AF), and arrhythmia were based on the genome-wide association study (GWAS) dataset. No disease group was intersected. Inverse-variance weighted (IVW) method was used to calculate MR estimates, and sensitivity analysis was performed.ResultsThe primary MR analysis showed that genetic susceptibility to RA was significantly associated with the risk of IHD and MI, rather than with AF and arrhythmia. Besides, there was no heterogeneity and horizontal pleiotropy between the primary and replicated analyses. There was a significant correlation between RA and the risk of IHD (odds ratio (OR), 1.0006; 95% confidence interval (CI), 1.000244–1.00104; P = 0.001552), meanwhile, there was a significant correlation between RA and the risk of MI (OR, 1.0458; 95% CI, 1.07061–1.05379; P = 0.001636). The results were similar to those of sensitivity analysis, and the sensitivity analysis also verified the conclusion. Furthermore, sensitivity and reverse MR analyses suggested that no heterogeneity, horizontal pleiotropy or reverse causality was found between RA and cardiovascular comorbidity.ConclusionRA was noted to be causally associated with IHD and MI, rather than with AF and arrhythmia. This MR study might provide a new genetic basis for the causal relationship between RA and the risk of CVD. The findings suggested that the control of RA activity might reduce the risk of cardiovascular disease.

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Section: Discussionsupporting

confidence: 45%

Relationship between rheumatoid arthritis and cardiovascular comorbidity, causation or co-occurrence: A Mendelian randomization study

Min

Chao

Mei

et al. 2023

Front. Cardiovasc. Med.

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“…No miocárdio, a presença de inflamação localcomo miocardite e pericarditee fibrose pode causar disfunção diastólica ou sistólica e subsequente hipertrofia cardíaca. Estas alterações na vasculatura Coração em foco: explorando os aspectos fundamentais da saúde cardíaca coronária e no tecido miocárdico podem resultar em arritmias cardíacas, insuficiência auditiva e morte cardíaca súbita 42 .…”

Section: Artrite Reumatoideunclassified

A Interação Complexa Entre O Diagnóstico De Doença Autoimune E O Risco De Comprometimento Cardiovascular

Leite,

Carneiro,

Bona

et al. 2024

Coração Em Foco: Explorando Os Aspectos Fundamentais Da Saúde Cardíaca

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“…At the myocardial level, the presence of local inflammation (myocarditis, pericarditis) and fibrosis may cause diastolic or systolic dysfunction and subsequent cardiac hypertrophy. These changes in the coronary vasculature and myocardial tissue can lead to cardiac arrhythmias, hear failure and sudden cardiac death ( 61 ).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Cardiac damage in autoimmune diseases: Target organ involvement that cannot be ignored

et al. 2022

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Autoimmune diseases are diseases that cause damage to the body’s own tissues as a result of immune dysfunction, often involving multiple organs and systems. The heart is one of the common target organs of autoimmune diseases. The whole structure of the heart can be affected, causing microcirculatory disorders, arrhythmias, pericardial damage, myocarditis, myocardial fibrosis, and impaired valvular function. However, early clinical manifestations of autoimmune heart damage are often overlooked because they are insidious or have no typical features. The damage is often severe and irreversible when symptoms are apparent, even life-threatening. Therefore, early detection and treatment of heart damage in autoimmune diseases is particularly important. Herein, we review the clinical features and mechanisms of cardiac damage in common rheumatic diseases.

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Animal models to study pathogenesis and treatments of cardiac disorders in rheumatoid arthritis: Advances and challenges for clinical translation

Cited by 5 publications

References 105 publications

Relationship between rheumatoid arthritis and cardiovascular comorbidity, causation or co-occurrence: A Mendelian randomization study

Relationship between rheumatoid arthritis and cardiovascular comorbidity, causation or co-occurrence: A Mendelian randomization study

A Interação Complexa Entre O Diagnóstico De Doença Autoimune E O Risco De Comprometimento Cardiovascular

Cardiac damage in autoimmune diseases: Target organ involvement that cannot be ignored

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