Animal models to test drugs with potential antidiabetic activity

Fröde, Tânia Sílvia; Medeiros, Yara S.

doi:10.1016/j.jep.2007.10.038

Cited by 244 publications

(175 citation statements)

References 107 publications

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“…b Triglycerides level before and after treatment. All the values were found to be significant with diabetic control at *P \ 0.05; **P \ 0.01; ***P \ 0.001 under the curve which is significantly lesser than the diabetic control group, and these findings are in accordance with previous research [36]. Figure 5 demonstrates the level of changes in body weight of experimental rats at before and after treatment.…”

Section: The Antidiabetic Activity Of Phytosynthesized Agnpssupporting

confidence: 89%

“…Alloxan-induced diabetic rat model has been widely used in several studies [34,35]. In addition, the mode of action of alloxan is well documented [36]. In the treatment of diabetes, blood glucose concentration is considered as a routine and major biochemical marker to monitor the improvement in the disease condition, the results obtained for blood glucose concentration of treated groups showed a smaller total area Fig.…”

Section: The Antidiabetic Activity Of Phytosynthesized Agnpsmentioning

confidence: 99%

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Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats

Sudalai¹,

Aravinthan

Sudhakar³

et al. 2015

J Nanostruct Chem

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Solanum nigrum, a medicinal plant, traditionally used in treating diabetes mellitus. In this study, we used the leaf extract of the plant to synthesize silver nanoparticles (AgNPs), as a proposition to treat alloxaninduced diabetic rats. The phytosynthesised AgNPs were analyzed using UV-visible and Fourier transform infra-red spectroscopy for their functional groups. Transmission electron microscopy revealed that, the synthesized particles are found to be 4-25 nm in size. Monodispersed and spherical nature of synthesized AgNPs were shown by scanning electron microscope and the presence of Ag in the AgNPs was confirmed by energy dispersive spectrum. The phytosynthesised AgNPs were evaluated for its antidiabetic activity in alloxan-induced diabetic rats. AgNPs-treated diabetic rats found to be significantly improved the dyslipidemic condition as seen in the diabetic control. Furthermore, it also reduced the blood glucose level over the period of treatment. The improvement in body weight was also found to be evidence for S. nigrum extract-mediated AgNPs as a potential antidiabetic agent against alloxaninduced diabetic rats.

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Section: The Antidiabetic Activity Of Phytosynthesized Agnpssupporting

confidence: 89%

Section: The Antidiabetic Activity Of Phytosynthesized Agnpsmentioning

confidence: 99%

Synthesis and characterization of Solanum nigrum-mediated silver nanoparticles and its protective effect on alloxan-induced diabetic rats

Sudalai¹,

Aravinthan

Sudhakar³

et al. 2015

J Nanostruct Chem

View full text Add to dashboard Cite

show abstract

“…Streptozotocin, 2-deoxy-2-(3-(methyl-3-nitrosoureido)-D-glucopyranose, is by far the most frequently used agent (69%) in preparation of diabetic animal models for the study of multiple aspects of diabetes, and the dose required for inducing diabetes depends on the animal species, route of administration and nutritional status [9] . Consequently, in the present study a preliminary dose response effect of STZ on blood glucose (standardization) was carried out to determine the optimum dose needed to produce stable hyperglycemia in Sprague Dawley rats, as data in the literature could not be relied upon due to broad variability [10,11] .…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and anti–hyperglycemic study of Gynura procumbens leaf extracts

Algariri

Meng

Atangwho

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…Glibenclamide is a standard drug that is routinely used in the treatment of diabetes [15]. The extract's ability to significantly reduce hyperglycemia induced by alloxan may indicate a similar mechanism with glibenclamide which, being a sulphonylurea stimulates the release of insulin [16]. Alloxan destroys pancreatic β-cells and thus reduces or completely inhibit insulin secretion resulting in hyperglycemia [14].…”

Section: Discussionmentioning

confidence: 99%