Animal pharmacology of CP-148,623, a cholesterol absorption inhibitor

Bangerter, F.W.; Zaccaro, Lawrence M.; Wilkins, Robert W.; Woody, Heidi A.; Wilder, D.W.; Sugarman, Elliot; DeNinno, Michael P.; McCarthy, Peter; Wilson, T.W.; Chandler, Charles F.; Morehouse, Lee A.

doi:10.1016/0021-9150(94)94240-4

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“…CP-148,623 is a synthetic saponin with very low bioavailabilie2 that has been shown to markedly inhibit cholesterol absorption in animal mod-e1s. 14,15,23 It was used in this study to explore the impact of reduced cholesterol absorption on serum LDL cholesterol levels. We found that the drug (600 mg/day) inhibited cholesterol absorption by 38%, increased cholesterol excretion by 71%, and lowered serum LDL cholesterol levels by 12% in healthy volunteers.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of cholesterol absorption with CP-148,623 lowers serum cholesterol in humans*

Harris

Windsor

Newton

et al. 1997

Clin Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Inhibition of cholesterol absorption with CP-148,623 lowers serum cholesterol in humans*

Harris

Windsor

Newton

et al. 1997

Clin Pharmacol Ther

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Steroids

Morgan¹,

Moynihan²

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Steroids are members of a large class of lipid compounds called terpenes that are biogenically derived from the same parent compound, isoprene, C 5 H 8 . Steroids contain or are derived from the perhydro‐1,2‐cyclopentenophenanthrene ring system and are found in a variety of different marine, terrestrial, and synthetic sources. Nonhormonal steroids, eg, sterols and bile acids; vitamin D; and hormonal steroids, eg, the human sex hormones (androgens, estrogens, and progestins) and corticosteroids (glucocorticoids and mineralocorticoids) play critical roles in the physiology and biochemistry of most living creatures. Other naturally occurring steroids, such as plant steroids, marine steroids, ecdysteroids, cardiac steroids, steroid alkaloids, and steroid antibiotics, have a plethora of biological activities and uses. Many synthetic steroids are the product of pharmaceutical research that has resulted in the development of several steroid‐based medicines with a market value over $10 billion. Among the medicinally important synthetic steroids, are antihormones, anesthetics, antiinflammatories, antiasthmatics, contraceptive drugs, antibiotics, anticancer agents, cardiovascular agents, and osteoporosis drugs.

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New targets for lipid lowering and atherosclerosis prevention

Sirtori¹

1995

Pharmacology & Therapeutics

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Animal pharmacology of CP-148,623, a cholesterol absorption inhibitor

Cited by 3 publications

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Inhibition of cholesterol absorption with CP-148,623 lowers serum cholesterol in humans*

Inhibition of cholesterol absorption with CP-148,623 lowers serum cholesterol in humans*

Steroids

New targets for lipid lowering and atherosclerosis prevention

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