Animal Studies Relating to Caries Inhibition by Fluoride

Larson, Rh

doi:10.1159/000260295

Cited by 11 publications

(4 citation statements)

References 31 publications

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“…The effec tiveness of fluoride has been established in both man [Ericsson, 1977] and experi mental animals [Larson, 1977], whereas the evidence for organic phosphates rests large ly on animal experimentation [Harris, 1970;Grenby, 1975Grenby, ,1977.…”

mentioning

confidence: 99%

Use of High-Performance Liquid Chromatography Techniques to Study the Protection of Hydroxylapatite by Fluoride and Glycerophosphate against Demineralization in vitro

Grenby¹,

Bull²

1980

Caries Res

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Apparatus and techniques were evolved for a sensitive and reproducible test measuring the demineralization by acid of hydroxylapatite or powdered enamel as the stationary phase in high-performance liquid chromatography columns. Demineralization was quantified by monitoring the column eluate for UV absorbance and integration of the area of the UV peaks, with concomitant serial calcium analyses. Treating the hydroxylapatite with sodium fluoride conferred relatively long-acting protection against demineralization. The main effect of the fluoride appeared to be in reducing the acid solubility of the outer layers of the hydroxylapatite. Contrary to earlier theories that the protective action of calcium glycerophosphate was exerted only in the media surrounding the teeth, this agent was found to interact directly with hydroxylapatite, reducing the extent of demineralization by an average of 50%. The UV and the calcium analysis data showed how the mechanisms of protection by glycerophosphates and fluoride differed.

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mentioning

confidence: 99%

Use of High-Performance Liquid Chromatography Techniques to Study the Protection of Hydroxylapatite by Fluoride and Glycerophosphate against Demineralization in vitro

Grenby¹,

Bull²

1980

Caries Res

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“…Larson (33), in a review of the literature, found some studies that seemed to show a preeruptive effect of fluoride on rat caries, while other studies failed to show such an effect. Some studies have shown an effect when the mother received fluoride during lactation.…”

Section: Systemic Vs Topical Effects Of Ingested Fluoridesmentioning

confidence: 99%

Appropriate Uses of Systemic Fluoride: Considerations for the ′90s

Leverett

1991

J Public Health Dent

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“…Fluoride rinses and tablets have, however, reduced caries without significant increase in en amel fluoride [Shern et al, 1977;Aasenden et al, 1972], Consequently, the importance of fluoride content in enamel has recently been questioned, and it has been suggested that fluoride content in local environment surrounding the tooth may be more im portant [Fejerskov et al, 1981;Larson, 1977]. This may be also important with fluoride varnishes, since fluoride from the varnish is released slowly, and the fluoride content of oral fluids and plaque may thus be increased for a longer time.…”

Section: Enamel Fluoridementioning

confidence: 99%

Fluoride Content and Calcium Release from Enamel, in Relation to Rat Caries following the Application of Fluoride Varnishes

Seppä¹,

Luoma²

1983

Caries Res

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195 Osborne-Mendel rats were weaned 19 days afterbirth and fed cariogenic diet for 42 days. The control group received no treatment. The study groups received applications of sodium fluoride varnish (Duraphat®) or silane fluoride varnish (Fluor Protector®), or a placebo varnish, either on days 19–21 or on days 25–27. After the experimental period, fluoride content and the release of calcium from the enamel was determined in two upper molars. The fluoride content of enamel was considerably increased in groups treated with fluoride varnishes. More fluoride was taken up from Fluor Protector than from Duraphat. The release of calcium and caries were, however, reduced more by Duraphat.

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Animal Studies Relating to Caries Inhibition by Fluoride

Cited by 11 publications

References 31 publications

Use of High-Performance Liquid Chromatography Techniques to Study the Protection of Hydroxylapatite by Fluoride and Glycerophosphate against Demineralization in vitro

Use of High-Performance Liquid Chromatography Techniques to Study the Protection of Hydroxylapatite by Fluoride and Glycerophosphate against Demineralization in vitro

Appropriate Uses of Systemic Fluoride: Considerations for the ′90s

Fluoride Content and Calcium Release from Enamel, in Relation to Rat Caries following the Application of Fluoride Varnishes

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