Animal studies supporting the inhibition of mast cell activation by <i>Eriobotrya japonica</i> seed extract

Onogawa, Masahide; Sun, Guangchen; Takuma, Daisuke; Hamada, Atsuhide; Yokota, Junko; Yoshioka, Saburo; Kusunose, Masahiko; Miyamura, Mitsuhiko; Kyotani, Shojiro; Nishioka, Yasuhiko

doi:10.1211/jpp.61.02.0014

Cited by 6 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This wide spectrum of biological activity has been attributed largely to loquat contents of antioxidant compounds such as flavonoids and polyphenols, in addition to the presence of triterpenes, glycosides, and sesquiterpenes. 3, 5 For example, several kinds of flavonoids, epicatechin, epicatechin gallate, methyl chlorogenate, cinchonain as well as quercetin, isoquercetin, quercetin-glycoside, and kaempferol glycosides have been isolated from loquat seed, leaf, and fruit. Ferreres et al and others showed that loquat leaves, flowers, and fruits contain flavonoids and polyphenols and their contents exhibited a positive correlation with their antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Extracts of Eriobotrya japonica (Loquat) Seeds, Leaves, and Fruits Have Anti-obesity and Hypolipidemic Effects in Rats

Abdelrahman

Bustanji

Abdalla

2022

Pharmacognosy Magazine

View full text Add to dashboard Cite

Background: Obesity is a serious public health problem contributing to development of several diseases, including hyperlipidemia, hyperglycemia, and hypertension. The plant Eriobotrya japonica (loquat) has been used in traditional Chinese medicine to treat many ailments and traditional healers used it to reduce weight. Objective: To examine the potential anti-obesity and hypolipidemic effects of ethanol extract of loquat in rats. Materials and Methods: Loquat leaves, fruits, or seeds were extracted with ethanol. About 96 Wistar male rats were fed either a normal rat diet (normal control group; group 1) or a high-fat diet (HFD) for 12 weeks (obese; groups 2−12). Obese rats were divided into11 groups as follows: (obese control: group 2) (obese positive control which received the hypolipidemic reference drug atorvastatin: group 3). Groups (4−6), (7−9), and (10−12) were given seed, leaf, or fruit extract, respectively, at 40,100, and 400 mg/kg. Body weight, serum glucose, lipid profile, creatinine, liver enzymes, albumin, and total protein were measured weekly. Results: HFD consumption significantly increased body weight and serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very-low density lipoprotein (VLDL), and glucose and decreased HDL compared to rats fed the normal diet. HFD also increased serum glutamic-oxaloacetic transaminase (GOT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and creatinine but decreased serum albumin and total protein. Administration of E. japonica seed, leaf, or fruit extract significantly decreased body weight, TC, TGs, LDL, VLDL, glucose, liver, and renal enzymes but increased HDL, albumin, and total protein levels. Conclusion: E. japonica seed, leaf, and fruit ethanol extract regulates body weight gain, has hypolipidemic properties, and positively affects liver and kidney enzymes.

show abstract

Section: Introductionmentioning

confidence: 99%