Anion Control of Sodium Absorption in the Colon

Roediger, W. E. W.; Deakin, E. J.; Radcliffe, Barbara; Nance, S.H.

doi:10.1113/expphysiol.1986.sp002978

Cited by 18 publications

(4 citation statements)

References 44 publications

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“…The large intestine is the site of intense anaerobic bacterial activity, and so these anions may influence fermentation in the colon (Allison & Macfarlane, 1988). Furthermore, nitrite affects colonic mucosal metabolism in the rat, as lumen nitrite augments sodium absorption, possibly by stimulating P-oxidation in the colonocyte (Roediger et al 1986).…”

Section: Nitrate: Nitrite: Human Colon: Ileostomymentioning

confidence: 99%

The effect of dietary nitrate on nitrate and nitrite excretion in man

1990

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Dietary nitrate and nitrite may affect colonic pathophysiology. These anions influence fermentation, and nitrite has been shown to augment sodium absorption by the colon and participate in the formation of N-nitroso compounds. There is, however, no general agreement as to how much dietary nitrate and nitrite reaches the colon. To help resolve this question, balance studies were performed on six healthy ileostomy subjects who were given diets that varied in nitrate content from 0.83 to 5.20 mmol/d. Nitrate and nitrite excretion in ileal effluent and urine were measured by anion-exchange chromatography with conductivity detection. There was no significant nitrite in the diets, urine or ileal effluent. Dietary nitrate was largely excreted in urine (1.31425 mmol/d). The urinary excretion findings indicated net synthesis of nitrate at low dietary intakes and net catabolism of nitrate at high intakes. Nitrate losses in ileal effluent were very low (0.03405 mmol/d, O.OM.06 mmol/kg) and unrelated to intake for all the diets. It is concluded that dietary nitrate and nitrite do not enter the colon from the small intestine in amounts that would affect fermentation and mucosal metabolism in man. The possibility of significant amounts of nitrate reaching the colon via blood in normal subjects has not been excluded.

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Section: Nitrate: Nitrite: Human Colon: Ileostomymentioning

confidence: 99%

The effect of dietary nitrate on nitrate and nitrite excretion in man

1990

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“…On the other hand, NO/cGMP signaling stimulates mitochondrial biogenesis through the activation of PGC-1α [91]. Nitrite (5 mmol/l) promotes the oxidation of butyrate in rat colonic cells [92]. It should be stressed that the concentration used in this study was far over the physiological levels of nitrite reported in the rat colon (~ 1 µmol/l).…”

Section: Nitric Oxide-speciesmentioning

confidence: 84%

The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health

et al. 2021

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Recent research demonstrates a reciprocal relationship between gut microbiota-derived metabolites and the host in controlling the energy homeostasis in mammals. On the one hand, to thrive, gut bacteria exploit nutrients digested by the host. On the other hand, the host utilizes numerous products of gut bacteria metabolism as a substrate for ATP production in the colon. Finally, bacterial metabolites seep from the gut into the bloodstream and interfere with the host’s cellular bioenergetics machinery. Notably, there is an association between alterations in microbiota composition and the development of metabolic diseases and their cardiovascular complications. Some metabolites, like short-chain fatty acids and trimethylamine, are considered markers of cardiometabolic health. Others, like hydrogen sulfide and nitrite, demonstrate antihypertensive properties. Scientific databases were searched for pre-clinical and clinical studies to summarize current knowledge on the role of gut microbiota metabolites in the regulation of mammalian bioenergetics and discuss their potential involvement in the development of cardiometabolic disorders. Overall, the available data demonstrates that gut bacteria products affect physiological and pathological processes controlling energy and vascular homeostasis. Thus, the modulation of microbiota-derived metabolites may represent a new approach for treating obesity, hypertension and type 2 diabetes.

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“…While short chain fatty acids may bind to the mucoglycoproteins,j little is known about the functional effects of short chain fatty acidmucoglycoprotein binding or of their effects on transport of other short chain fatty acids. Na' ion transport is significantly affected by the presence of short chain fatty acids.Z2* [26][27][28] Sodium butyrate (concentration of 25 mmol) always altered the Na'/H exchange. The cationic exchange capacity of group 1 mucus was reduced.…”

Section: Discussionmentioning

confidence: 99%

The ion exchange properties of human post‐mortem caecal and colonic mucus: The effect of sodium butyrate

Duncan

Tasman-Jones

1992

J of Gastro and Hepatol

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This study examined Na+/H+ ion exchange of caecal and colonic mucus. Two distinct Na+/H+ ion exchange populations of caecal mucus were identified, one group being a cation exchanger and the other an anion exchanger, suggesting that caecal mucus has ampholyte properties responsive to changing physical and chemical properties of luminal contents. Mucus from the colon was consistently an anionic exchanger--this may aid water and electrolyte absorption in the colon. When mucus was incubated with sodium butyrate, the Na+/H+ ion exchange properties of the mucus were decreased.

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Anion Control of Sodium Absorption in the Colon

Cited by 18 publications

References 44 publications

The effect of dietary nitrate on nitrate and nitrite excretion in man

The effect of dietary nitrate on nitrate and nitrite excretion in man

The impact of gut microbiota metabolites on cellular bioenergetics and cardiometabolic health

The ion exchange properties of human post‐mortem caecal and colonic mucus: The effect of sodium butyrate

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