Anion effects on electrostatic charging of sterically stabilized, water insoluble drug particles

Owen, Heather; Graham, Sabine; Werling, Jane; Carter, Phillip W.

doi:10.1016/j.ijpharm.2008.10.004

Cited by 12 publications

(7 citation statements)

References 18 publications

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“…Generally, the less negative values are noted for more HEMA content. These data agree with Owen's results22 which showed that the more hydrophilic anions had the least negative ζ potential SDS samples. In addition, the observed low ζ potential can be attributed to the screening effect of PVP, which shifts the shearing plan position far from the charged surface of the particles.…”

Section: Resultssupporting

confidence: 92%

“…The differential continuous17–20 microemulsion polymerization is an alternative method to overcome this drawback, through adding the monomer continuously through a long period of time. Nanolatexes with such characteristics are desirable for certain applications, such as high‐performance nanocoating, encapsulation of dyes,21 or drug delivery 22–28…”

Section: Introductionmentioning

confidence: 99%

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Differential microemulsion polymerization as a new root for entrapment of drugs

Moustafa

Sobh

Rabie

et al. 2012

J of Applied Polymer Sci

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Nanosized particles derived from poly(methyl methacrylate) as well as copolymer of methyl methacrylate (MMA) and 2hydroxyethyl methacrylate (HEMA) were synthesized by differential microemulsion technique in the presence of ammonium persulfate as water-soluble initiator. The polymerization was stabilized by adding biologically safe emulsifiers namely the sodium dodecyl sulfate (SDS) or polyvinyl pyrrolidone (PVP) either alone or in conjunction with polyethylene glycol. The turbidity measurements, surface tension, f potential, and morphological characterizations of the obtained nanosized poly MMA and its copolymer with HEMA in different monomer feed compositions were investigated. It is found that increasing HEMA content leads to increase in the particle size, turbidity measurements but the negatively charged f potential decreased. However, when SDS is used, the surface tension of the prepared lattices increased, whereas it is decreased by using PVP. Kinetic studies of (MMA/HEMA) in ratio of 95/5 wt % in the presence of SDS or PVP revealed that the emulsifier concentration has a considerable effect on the rate of polymerization and the power of the emulsifier. The entrapment of drug was investigated using two active molecules different in water solubility (sodium warfarin and ibuprofen). It is noted that entrapment efficiency is independent of HEMA content in the monomer feed composition but dependent on type of drug and the amount of drug introduced. Hence, higher entrapment efficiency was attained for sodium warfarin (more hydrophilic) than that of ibuprofen (more hydrophobic) and they were 95.5 and 85%, respectively.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Differential microemulsion polymerization as a new root for entrapment of drugs

Moustafa

Sobh

Rabie

et al. 2012

J of Applied Polymer Sci

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“…A water-insoluble suspension of budesonide was sterically stabilized using polysorbate 80. 19 Polysorbate 80 is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid. Disodium edetate is a parenteral chelating agent.…”

Section: Discussionmentioning

confidence: 99%

Effect of Surfactant and Budesonide on the Pulmonary Distribution of Fluorescent Dye in Mice

Huang

Yeh

Kuo

et al. 2015

Pediatrics & Neonatology

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“…The contact angle and surface tension (ST) values of the stabilizers such as hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone K30 (PVP K30), sodium dodecyl sulfate (SDS), dioctyl sodium sulfosuccinate (DOSS), poloxamer 188 (P188), poloxamer 407 (P407), tween 80 (TW 80), tween 20 (TW 20), and carboxymethylcellulose sodium (CMC-Na) are given in Table 2 and we designed the experiment according to Table 3. Based on the overall results of the trend analysis, it is now possible to develop a formulation design space with a critical set of API and stabilizer properties, from which generic formulations can be chosen for a stable nanosuspension [17]. This combination of properties can be used as a guide for choosing a stabilizer for the drugs because the most likely candidate for media milling was an API with high enthalpy and hydrophobicity, which can be stabilized either electrostatically or sterically [17].…”

Section: Particle Size Distribution (Psd) Of the Freshly Milled Productmentioning

confidence: 99%

Preparation of Nanocrystals for Insoluble Drugs by Top-Down Nanotechnology with Improved Solubility and Bioavailability

Zhang

Gao

et al. 2020

Molecules

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Midazolam is a rapidly effective benzodiazepine drug that is widely used as a sedative worldwide. Due to its poor solubility in a neutral aqueous solution, the clinical use of midazolam is significantly limited. As one of the most promising formulations for poorly water-soluble drugs, nanocrystals have drawn worldwide attention. We prepared a stable nanosuspension system that causes little muscle irritation. The particle size of the midazolam nanocrystals (MDZ/NCs) was 286.6 ± 2.19 nm, and the crystalline state of midazolam did not change in the size reduction process. The dissolution velocity of midazolam was accelerated by the nanocrystals. The pharmacokinetics study showed that the AUC0–t of the MDZ/NCs was 2.72-fold (p < 0.05) higher than that of the midazolam solution (MDZ/S), demonstrating that the bioavailability of the MDZ/NC injection was greater than that of MDZ/S. When midazolam was given immediately after the onset of convulsions, the ED50 for MDZ/NCs was significantly more potent than that for MDZ/S and DZP/S. The MDZ/NCs significantly reduced the malondialdehyde content in the hippocampus of the seizures model rats and significantly increased the glutathione and superoxide dismutase levels. These results suggest that nanocrystals significantly influenced the dissolution behavior, pharmacokinetic properties, anticonvulsant effects, and neuroprotective effects of midazolam and ultimately enhanced their efficacy in vitro and in vivo.

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Anion effects on electrostatic charging of sterically stabilized, water insoluble drug particles

Cited by 12 publications

References 18 publications

Differential microemulsion polymerization as a new root for entrapment of drugs

Differential microemulsion polymerization as a new root for entrapment of drugs

Effect of Surfactant and Budesonide on the Pulmonary Distribution of Fluorescent Dye in Mice

Preparation of Nanocrystals for Insoluble Drugs by Top-Down Nanotechnology with Improved Solubility and Bioavailability

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