Anion permeability of the synaptic and non‐synaptic motoneurone membrane

Araki, T.; Ito, Masao; Oscarsson, O.

doi:10.1113/jphysiol.1961.sp006818

Cited by 173 publications

(88 citation statements)

References 39 publications

(44 reference statements)

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“…In the present experiments the relative anion permeability of the post-synaptic membrane was estimated from the relative value of the conductance change during GABA action and it was observed that the (Robinson & Stokes, 1955). Filled circles: naked ion sizes (Araki et al 1961). …”

Section: Discussionmentioning

confidence: 74%

“…The anion species which pass through the activated post-synaptic membrane have been investigated on mammalian motoneurones (Coombs et al 1955;Araki et al 1961;Ito et al 1962), Mauthner cells (Asada, 1963), and snail ganglion cells (Kerkut & Thomas, 1964). In these experiments various anions were injected into nerve cells.…”

Section: Discussionmentioning

confidence: 99%

“…The present experiment showed that the activated inhibitory post-synaptic membrane is slightly permeable to BrO3-. Since this anion does not cross the activated inhibitory synapse of motoneurones (Araki et al 1961), the permeability of BrO3-was investigated further. After the muscle was washed in Cl-free solution for 3 hr, little conductance change occurred (0O1 x 1O-7 mho) when GABA was applied.…”

Section: Anion Permeability Of Inhibitory Nmj 583mentioning

confidence: 99%

“…The permeability of the inhibitory post-synaptic membrane has been investigated extensively by injecting anions with finely graded hydrated ion sizes into cat spinal motoneurones (Coombs, Eccles, &, Fatt, 1955;576 A. TAKEUCHI AND NORIKO TAKEUCHI Araki, Ito & Oscarsson, 1961;Ito, Kostyuk & Oshima, 1962) and these anions have been classified into penetrating and non-penetrating anions through the activated inhibitory post-synaptic membrane. It has been shown that the ability of anions to penetrate the activated inhibitory postsynaptic membrane is related to their relative hydrated sizes, in keeping with the pore-structure hypothesis.…”

Section: Introductionmentioning

confidence: 99%

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Anion permeability of the inhibitory post‐synaptic membrane of the crayfish neuromuscular junction

Takeuchi¹,

Takeuchi²

1967

The Journal of Physiology

215

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SUMMARY1. The membrane conductance of the crayfish muscle fibre was calculated and the increase in the membrane conductance brought about by the application of y-aminobutyric acid (GABA) was investigated under various conditions. The permeability of the activated inhibitory postsynaptic membrane was estimated from the conductance change.2. When the concentration of Cl-was changed by substituting CO-with methylsulphate, a linear relation was obtained between the membrane conductance change produced by GABA and the concentration of C1-. Cations have no appreciable effect on the GABA induced conductance change (less than 0-4 %).3. The conductance change produced by GABA on the inhibitory postsynaptic membrane was measured in various solutions in which the Clwas replaced by various anions. The degree of permeability depended on the anion species in the following order:Br-> Cl-> SON-> I-> N03-> HCOO-> C103-> C104-> BrO3-4. At high pH the conductance change produced by GABA was decreased, while at low pH it increased.5. These results show that the activated inhibitory post-synaptic membrane of crayfish muscle fibres has the characteristics of an anion selective membrane, suggesting the fixed positive charges in the inhibitory membrane.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Anion Permeability Of Inhibitory Nmj 583mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anion permeability of the inhibitory post‐synaptic membrane of the crayfish neuromuscular junction

Takeuchi¹,

Takeuchi²

1967

The Journal of Physiology

215

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“…

Ito & Oscarsson, 1961; Coombs, Eccles & Fatt, 1955).3. Studied with potassium chloride filled micropipettes.

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confidence: 99%

Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones

Burke¹,

Fedina²,

Lundberg³

1971

The Journal of Physiology

111

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Ito & Oscarsson, 1961; Coombs, Eccles & Fatt, 1955).3. Studied with potassium chloride filled micropipettes. the reversal potential for the group I a IPSP was found to be different from that for the recurrent IPSP when the amount of Cl-diffusing or iontophoretically injected into the motoneurone was small. The amount of difference in reversal potential varied from cell to cell but when present the group I a IPSP reversed to a depolarizing potential more readily than the recurrent IPSP in all cases.4. Interaction between recurrent IPSPs and monosynaptic excitatory post-synaptic potentials (EPSPs) was also studied and the amount of nonlinearity of potential summation was measured.5. The results are consistent with the hypothesis that the terminations of Renshaw cells responsible for the recurrent IPSP are located largely on the proximal dendrites of motoneurones, while the terminations of the interneurones generating the group I a IPSP appear to be closer to or on the cell somata.

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Der Mechanismus der postsynaptischen Hemmung Nobel‐Vortrag am 11. Dezember 1963

Eccles

1964

Angewandte Chemie

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ACT (AUSTRALIEN) Der Zellkorper und die Dendriten einer Nervenzelle dienen zur Aufnahme und Verarbeitung der Informationen, die ihnen durch Impulse entlang den Axonen anderer Ner\ enzellen zugeleitet werden. Die schematische'Darstellung einer Nervenzelle (Abb. 1 A) zeigt, daR die Axone anderer Nervenzellen als zahlreiche feine Fasern mit kleinen Verdickungen, den Endknopfchen, auf der Oberflache der Nervenzelle endigen. Die Informationsubertragung zwischen den Nervenzellen erfolgt an diesen Stellen engen Kontaktes, die Synapsen genannt werden. Diesen Namen hat Sherrington eingefuhrt, dessen Forschungen die Grundlage legten fur das, was heute oft Synaptologie genannt wird. Wir verdanken Abb. I . A: Schematische Zeichnung einer Nervenzelle. Vom Zellkorper (Soma), der den Zellkern enthalt, gehen Dendriten und das Axon aus. Zahlreiche feinste Verzweigungen mehrerer Nervenfasern enden als Endknopfchen auf der Oberflache des Zellkorpers und der Dendriten 111. B: EIektronenmikroskopische Aufnahme eines Endknopfchens, das von der subsynaptischen Membran einer Nervenzelle durch einen etwa 200 A breiten subsynaptischen Spalt (Pfeile) getrennt ist. An manchen Stellen ist eine Haufung der synaptischen Blaschen in der Nahe der synaptischen Membran des Endknopfchens zu sehen. An diesen Stellen findet sich auDerdem eine Verdickung der Membran auf beiden Seiten des Spaltes C: Elektronenmikroskopische Aufnahme einer hemmenden Synapse, die yon dem Endknopfchen (pre) einer Korbzelle auf dem Zellkorper (cyt) einer Pyramidenzelle des Ammonshornes gebildet wird 131. unni = unmyeliniertes Axon, b = aktive Bereiche. [21.[*I Q 1964 The Nobel Foundation. -Das liebenswiirdige Entgegenkommen des Autors und der Nobel-Stiftung, Stockholm, ermoglicht es uns, diesen Nobel-Vortrag, der in den Veroffentlichungen der Nobel-Stiftung erst spiiter erscheinen wird, schon jetzt zu drucken.[I] R. Jlcng in: Handbuch der inneren Medizin. Springer, Heidelberg 1953, S. 1. [2] S. L. Palay, Exp. Cell Res., Suppl. 5, 275 (1958). [3] L. H . Hamlyn, J. Anatomy 97,189 (1963).Dale und Loewi die Erkenntnis, daB die Erregung an den Synapsen durch die Sekretion kleinster Mengen von Substanzen ubertragen wird, die iiber die Synapse hiniiberwirken. Die Fortleitung der Impulse iiber die Oberflache der Nervenzellen und ihrer Axone, die der Impulsfortleitung in einem Kabel gleicht, endet abrupt an den Synapsen und setzt sich eventuell auf der anderen Seite der Synapse wieder fort. Das groBe Auflosungsvermogen des Elektronenmikroskops hat es moglich gemacht, wesentliche Aufschliisse uber den morphologischen Bau der Synapsen, denen die chemische Phase der Erregungsiibertragung zufallt, zu erhalten. In Abbildung 1 B und C sehen wir z. B. die etwa 70 8, dicke Membran, welche die leicht verdickte axonale Endigung, das Endknopfchen, umschlieRt. Diese Endknopfchen enthalten zahlreiche kleine blaschenartige Strukturen, die s y n a p t i sch en B 1 a s c h e n , von denen angenommen wird, da13 sie die Substanz fur die synaptische Ubertragung enthalten. Ein Teil der synaptischen Bl...

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Anion permeability of the synaptic and non‐synaptic motoneurone membrane

Cited by 173 publications

References 39 publications

Anion permeability of the inhibitory post‐synaptic membrane of the crayfish neuromuscular junction

Anion permeability of the inhibitory post‐synaptic membrane of the crayfish neuromuscular junction

Spatial synaptic distribution of recurrent and group Ia inhibitory systems in cat spinal motoneurones

Der Mechanismus der postsynaptischen Hemmung Nobel‐Vortrag am 11. Dezember 1963

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