Anion receptor molecules. Synthesis and anion-binding properties of polyammonium macrocycles

Chemical speciation of nucleotide 5′-monophosphates in the presence of biogenic amines

“…A great number of studies have been carried out on the formation of mixed complexes of AMP, ADP and ATP with other ligands (generally amines and aminoacids) and divalent metal ions (M = Cu 2+ , Zn 2+ ) (Andrés et al, 1993;Antonelli et al, 1989;Bunce and Kong, 1978;Dietrich et al, 1981;Hosseini et al, 1987;Kimura et al, 1982;Kimura et al, 1990;Smith et al, 1991). Polyammonium cations can replace the metal bound to ATP, and this kind of reaction might be of considerable interest in the speciation of biological fluids.…”

Aspects of Anion Coordination from Historical Perspectives

“…However, while investigations on crown ethers rapidly evolved and many of these compounds were prepared and their chemistry widely explored, studies on anion coordination chemistry remained at the initial stage. Further development waited until Lehn and his group revisited this point in the late 1970s and beginning of the 1980s [56][57][58][59][60][61][62]. Nevertheless, evidence that anions interact with charged species, modifying their properties, in particular their acid-base behavior, was known from the early times of the development of speciation techniques in solution, when it was noted that …”

“…Since macrocycle 37 was found to be one of the most powerful complexing agents for ATP [58,215], it was attached to polysterene beads. The modified polymer was able to take up nucleotides, in particular ATP, at neutral and acidic pHs and release them back into the solution at basic pH values.…”

“…However, the most interesting point of this chemistry concerns the capacity that some polyammonium receptors have for inducing catalytic processes mimicking the behavior of ATPases or kinases. The 24-membered macrocyclic receptor 37 ranks among the abiotic receptors producing highest enhancements of ATP cleavage into ADP and the so-called inorganic phosphate [58,[215][216][217][218][219][220]. Activation of ATP-cleavage with 37 was observed not only at an acidic pH but also at neutral pH.…”

Étude théorique (AM1) de l'affinité protonique des polyéthers cycliques (éthers couronnes) et non cycliques (glymes)

“…11s prbentent des proprittCs aussi variCes qu'intkressanteset sont susceptib l e~ d'applications en catalyse, en synthbse organique et en biologie (2)(3)(4). A ce sujet un certain nombre de mises au point ont Ct C publikes (5)(6)(7)(8). Nous citons a titre d'exemple les structures cnstallines du 18-Cther-couronne-6 et ses complexes avec les sulfocyanures de divers metaux alcalins (9)(10)(11)(12)(13)(14).…”