Anion transport and supramolecular medicinal chemistry

Gale, Philip A.; Davis, Jeffery T.; Quesada, Roberto

doi:10.1039/c7cs00159b

Cited by 325 publications

(224 citation statements)

References 65 publications

(64 reference statements)

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“…Andere supramolekulare Rezeptoren, die in der Medizin eingesetzt werden können, sind Verbindungen, die Chloridionen entlang von Zellmembranen transportieren können und dadurch die Therapie der Symptome von Mukoviszidose ermöglichen . Diese Stoffwechselerkrankung beruht auf einer Fehlfunktion von membranständigen Proteinen, die für den Chloridtransport verantwortlich sind, und die synthetischen Rezeptoren sollen die Funktion dieser Proteine übernehmen.…”

Section: Die Gegenwartunclassified

Supramolekulare Chemie

Kubik

2017

Chemie in nserer Zeit

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Zusammenfassung Seit der Auszeichnung mit dem Nobelpreis vor 30 Jahren hat sich die Supramolekulare Chemie zu einem außerordentlich dynamischen und innovativen Forschungsgebiet entwickelt. Ausgehend von einer Vorstellung der drei Nobelpreisträger und ihrer Arbeiten werden in diesem Artikel die wissenschaftlichen Fragestellungen beschrieben, zu denen die Supramolekulare Chemie heute Beiträge leistet. Besonderes Augenmerk liegt dabei auf Beispielen für Systeme und Konzepte, die Eingang in praktische Anwendungen gefunden haben. Es soll dadurch verdeutlicht werden, dass die Supramolekulare Chemie die chemische Forschung der letzten Jahrzehnte maßgeblich mitgeprägt hat und sogar Ausgangspunkt für ganz neue Forschungsrichtungen war.

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Section: Die Gegenwartunclassified

Supramolekulare Chemie

Kubik

2017

Chemie in nserer Zeit

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“…The knowledge gained with synthetic carriers also contributes to the further understanding of the functioning of electrophysiological transport processes in natural systems and might bring significant advances in biomedical science and its potential therapeutic applications (e.g. disruption of cellular ion homeostasis) …”

Section: Introductionmentioning

confidence: 99%

Influence of the Insertion Method of Aryl‐Extended Calix[4]pyrroles into Liposomal Membranes on Their Properties as Anion Carriers

Martínez‐Crespo

Sun‐Wang

Ferreira

et al. 2019

Chemistry A European J

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We disclose the results of our investigations on the influence that the insertion method of aryl‐extended calix[4]pyrrole into liposomal membranes exerts on their properties as anion carriers. We use the standard HPTS assay to assess the transport properties of the carriers. We show that the post‐insertion of the carrier, as DMSO solution, assigns better transport activities to the “two‐wall” α,α‐aryl‐extended calix[4]pyrrole 1 compared to the “four‐wall” α,α,α,α‐counterpart 2 . Notably, opposite results were obtained when the carriers were pre‐inserted into the liposomal membranes. We assign this difference to an improved incorporation of carrier 2 into the membrane when delivered by the pre‐insertion method. On the other hand, carrier 1 shows comparable levels of transport independently of the method used for its incorporation. Thus, an accurate comparison of the chloride transport activities featured by these two carriers demands their pre‐incorporation in the liposomal membranes. In contrast, using the lucigenin assay with the pre‐insertion method both carriers displayed similar transport efficiencies.

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“…[1] While many synthetic molecules have been shown to transport inorganic anions [2][3][4][5] or metal-anion pairs, [6][7][8][9] the transport of primary ammonium-anion pairs across lipid bilayers by synthetic compounds has,t oo ur knowledge,n ot been demonstrated. [1] While many synthetic molecules have been shown to transport inorganic anions [2][3][4][5] or metal-anion pairs, [6][7][8][9] the transport of primary ammonium-anion pairs across lipid bilayers by synthetic compounds has,t oo ur knowledge,n ot been demonstrated.…”

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confidence: 99%

Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs

et al. 2019

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Given the biological importance of organic cations, the facilitated transport of organic ion pairs could find many applications.C alix[6]arene tris(thio)ureas,w hichp ossess ac avity that can accommodate primary ammonium ions,c an not only act as carriers for Cl À /NO 3 À antiport but can also perform the cotransport of PrNH 3 Cl. Transport was monitored by fluorescence spectroscopyand the presence of the different species inside the vesicles was characterized by 1 Ha nd 35 Cl NMR experiments involving shift reagents.The cotransport of PrNH 3 Cl was also observed by receptors deprived of acavity, but the presence of the cavity conveys an advantage,a st he cotransport by calix [6]arenes was observed to be more efficient than the Cl À /NO 3 À antiport, which is not the case with receptors without ac avity.T he role played by the cavity was further highlighted by the disappearance of this advantage when using abulkyammonium ion, whichcannot be complexed within the cavity.

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Anion transport and supramolecular medicinal chemistry

Cited by 325 publications

References 65 publications

Supramolekulare Chemie

Supramolekulare Chemie

Influence of the Insertion Method of Aryl‐Extended Calix[4]pyrroles into Liposomal Membranes on Their Properties as Anion Carriers

Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs

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