2008
DOI: 10.1007/s11064-008-9685-x
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Anionic Selectivity Sequence of the Cl−–H+ Symporter in the Synaptosomal Preparation from Rat Brain Cortex

Abstract: The Na(+)/H(+) exchanger has been the only unequivocally demonstrated H(+)-transport mechanism in the synaptosomal preparation. We had previously suggested that a Cl(-)-H(+) symporter (in its acidifying mode) is involved in cytosolic pH regulation in the synaptosomal preparation. Supporting this suggestion, we now show that: (1) when synaptosomes are transferred from PSS to either gluconate or sulfate solutions, the Fura-2 ratio remains stable instead of increasing as it does in 50 mM K solution. This indicate… Show more

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