Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes

Capped Mesoporous Silica Nanoparticles for the Selective and Sensitive Detection of Cyanide

“…As it can be seen, none of the tested chemicals were able to induce cargo delivery, pointing toward a highly selective response of NP3 solid toward cyanide anion. We recently reported hexametaphosphate‐capped nanoparticles functionalized with a Cu II macrocyclic complex, which were selectively uncapped only upon hydrogen sulfide addition . The previous and current results indicate that the selectivity of the hexametaphosphate‐capped nanoparticles can be properly addressed by changing the metal‐macrocyclic subunits grafted on their surface.…”

A Nanoprobe Based on Gated Mesoporous Silica Nanoparticles for The Selective and Sensitive Detection of Benzene Metabolite t,t‐Muconic Acid in Urine

“…Based on the above, and following our interest in the development of hybrid organic‐inorganic materials for the design of chromo‐fluorogenic sensing protocols as an alternative to molecular based probes, [34–41] we report herein the synthesis and characterization of a gated nanodevice for the selective and sensitive quantification of t,t‐MA in urine. The nanodevice used mesoporous silica nanoparticles (MSNs) [42, 43] as inorganic scaffold with the pores loaded with sulforhodamine B (SRh B) and capped with an inclusion complex formed between a terephthalic acid derivative (grafted onto the external surface of the solid) and a dicopper(II) bistren azacryptand (Scheme 1).…”

“…[30][31][32] In particular,v ery recently,A mendola and co-workers have demonstrated that t,t-MA can coordinate effectively to ad icopper(II) bistren azacryptanda nd developeda ni ndicator displacement assay for the fluorescences ensing of this benzene metabolite. [33] Based on the above, and following our interest in the development of hybrido rganic-inorganicm aterials for the design of chromo-fluorogenics ensing protocols as an alternative to molecular based probes, [34][35][36][37][38][39][40][41] we report herein the synthesis and characterization of ag ated nanodevice for the selectivea nd sensitiveq uantification of t,t-MA in urine. The nanodevice used mesoporouss ilica nanoparticles (MSNs) [42,43] as inorganic scaffold with the pores loaded with sulforhodamine B( SRh B) and capped with an inclusion complex formed between at erephthalic acid derivative (grafted onto the external surface of the solid) and ad icopper(II) bistren azacryptand (Scheme 1).…”

Sustained Protein Release from a Core‐Shell Drug Carrier System Comprised of Mesoporous Nanoparticles and an Injectable Hydrogel

“…Mesoporous silica nanoparticles are a material of choice for bioactive compound delivery due to their superior surface properties . These nanoparticles have been broadly used for peptide delivery into the cells due to the biocompatibility, stability, and the capacity to facilitate endocytosis .…”

“…We hypothesized that the delivery of bioactive agents via mesoporous silica nanoparticles suspended within a hydrogel carrier could overcome the challenges associated with both systems individually. The concept of combining organic and inorganic carriers has previously resulted in the preparation of hybrid materials with features that are not achievable with single component counterparts . Specifically, polymer modification of nanoparticles has been shown to facilitate a zero order kinetic release profile .…”